Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Molecular Pharmaceutics

Volumn 7, Issue 4, 2010, Pages 1041-1049

  Quan, Ling Dong ^a   Yuan, Fang ^a   Liu, Xin Ming ^a   Huang, Jian Geng ^a   Alnouti, Yazen ^a   Wang, Dong ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

arthrotropism; biodistribution; dexamethasone; HPMA copolymer; pharmacokinetics; prodrug; Rheumatoid arthritis

Indexed keywords

DEXAMETHASONE; IODINE 125; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; PRODRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; HEART; LIVER; LUNG; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLENECTOMY; SYNOVIUM;

ACRYLAMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; DEXAMETHASONE; MALE; POLYMERS; RATS;

EID: 77955251366     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100132h     Document Type: Article

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