Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis

Pharmaceutical Research

Volumn 25, Issue 12, 2008, Pages 2910-2919

  Liu, Xin Ming ^a   Quan, Ling Dong ^a   Tian, Jun ^a   Alnouti, Yazen ^a   Fu, Kai ^b   Thiele, Geoffrey M ^b   Wang, Dong ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Dexamethasone; Drug delivery; Macromolecular therapy; RAFT polymerization; Rheumatoid arthritis

Indexed keywords

COPOLYMER; DEXAMETHASONE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; N (2 HYDROXYPROPYL)METHACRYLAMIDE DEXAMETHASONE CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; BONE DENSITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOLECULAR WEIGHT; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ANKLE JOINT; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BONE DENSITY; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; MALE; METHACRYLATES; RATS; RATS, INBRED LEW; SOLUBILITY;

EID: 57149141676     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9683-3     Document Type: Conference Paper

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