Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers

Molecular Pharmaceutics

Volumn 3, Issue 6, 2006, Pages 717-725

  Wang, Dong ^a,c   Sima, Monika ^a   Mosley, R Lee ^d   Davda, Jasmine P ^c   Tietze, Nicole ^a,e   Miller, Scott C ^a   Gwilt, Peter R ^c   Kopečková, Pavla ^a   Kopeček, Jindřich ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e NONE   (Germany)

Author keywords

Biodistribution; Bone targeting; Drug delivery; HPMA copolymer; Pharmacokinetics; SPECT

Indexed keywords

COPOLYMER; DEXTRO ASPARTIC ACID; IODINE 125; N (2 HYDROXYPROPYL)METHACRYLAMIDE; OCTAPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BONE TURNOVER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR WEIGHT; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCYTE; OSTEOPOROSIS; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION;

ANIMALS; ASPARTIC ACID; BIOLOGICAL AVAILABILITY; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; DRUG DELIVERY SYSTEMS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; POLYMERS; POLYMETHACRYLIC ACIDS; TISSUE DISTRIBUTION; TYROSINE;

EID: 33846159896     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0600539     Document Type: Article

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