Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin

Bioconjugate Chemistry

Volumn 11, Issue 2, 2000, Pages 131-139

  Pechar, Michal ^a   Ulbrich, Karel ^a   Šubr, Vladimír ^a   Seymour, Leonard W ^b   Schacht, Etienne H ^c  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; CATHEPSIN B; COPOLYMER; DEGRADATION; DOXORUBICIN; DRUG BINDING SITE; DRUG DELIVERY SYSTEM; ENZYME SUBSTRATE; ENZYMIC HYDROLYSIS; MACROGOL; OLIGOPEPTIDE; POLYMER;

EID: 0034026798     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990092l     Document Type: Article

References (20)

1. Ulbrich, K. (1991) Water-soluble polymeric carriers of drugs. J. Bioact. Compat. Polym. 6, 348-357.
2. Duncan, R. (1992) Drug-polymer conjugates: potential for improved chemotherapy. Anti-Cancer Drugs 3, 175-210.
3. Říhová, B., Strohalm, J., Plocová, D., Šubr, V., Šrogl, J., Jelínková, M., Šírová, M., and Ulbrich, K. (1996) Cytotoxic and cytostatic effects of anti-Thy 1.2 targeted doxorubicin and cyclosporin A. J. Controlled Release 40, 303-319.
4. Ouchi, T., Kuroda, H., and Ohya, Y. (1997) Design of Antitumor Agent-Terminated Poly(Ethylene Glycol) Conjugate as Macromolecular Prodrug. Polym. Prepr. 38, 582-583.
5. Caliceti, P., Monfardini, C., Sartore, L., Schiavon, O., Baccichetti, F., Carlassare, F., and F. M. Veronese (1993) Preparation and Properties of Monomethoxy Poly(Ethylene Glycol) Doxorubicin Conjugates Linked by an Amino Acid or A Peptide As Spacer. Farmaco 48, 919-932.
6. Seymour, L. W., Miyamoto, Y., Maeda, H., Brereton, M., Strohalm, J., Ulbrich, K., and Duncan, R. (1995) Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur. J. Cancer 31A, 766-770.
7. Nathan, A., Zalipsky, S., and Kohn, J. (1994) Strategies for covalent attachment of doxorubicin to poly(PEG-Lys), a new water-soluble poly(ether urethane). J. Bioact. Compat. Polym. 9, 239-251.
8. Pechar, M., Strohalm, J., and Ulbrich, K. (1995) Synthesis of poly(ethylene glycol) block copolymers as potential water-soluble drug carriers. Collect. Czech. Chem. Commun. 60, 1765-1780.
9. Pechar, M., Strohalm, J., and Ulbrich, K. (1997) Biodegradable drug carriers based on poly(ethyleneglycol) block copolymers. Macromol. Chem. Phys. 198, 1009-1020.
10. Rejmanová, P., Pohl, J., Baudyš, M., Kostka, V., and Kopeček, J. (1983) Polymers containing enzymatically degradable bonds. 8. Makromol. Chem. 184, 2009-2020.
11. Jegorov, A., Tříska, J., and Trnka, T. (1994) 1-Thio-β-D-galactose as a chiral derivatization agent for the resolution of D, L-aminoacid enantiomers. J. Chromatogr. A 673, 286-290.
12. Jegorov, A., Tříska, J., Trnka T., and Černý, M. (1988) Separation of a-amino acid enantiomers by reversed-phase high-performance liquid chromatography after derivatization with o-phthaldialdehyde and a sodium salt of 1-thio-β-D-glucose. J. Chromatogr. 434, 417-434.
13. Zalipsky, S., and Lee, C. (1992) In Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (J. M. Harris, Ed.) pp 347-370, Plenum Press, New York.
14. Bodanszky, M., and Bodanszky, A. (1985) The Practice of Peptide Synthesis, Akademie-Verlag, Berlin.
15. Kenner, G. W., and Stedman, R. J. (1952) Peptides. Part I. The synthesis of peptides through anhydrides of sulphuric acid. J. Chem. Soc. 2069-2076.
16. Nathan, A., Bolikal, D., Vyavahare, N., Zalipsky, S., and Kohn, J. (1992) Hydrogels based on water-soluble poly(ether urethanes) derived from l-lysine and poly(ethylene glycol). Macromolecules 25, 4476-4484.
17. Ulbrich, K., Strohalm, J., Šubr, V., and Plocová, D. (1996) Polymeric conjugates of drugs and antibodies for site-specific drug delivery. Macromol. Symp. 103, 177-192.
18. Ulbrich, K., Pechar, M., Strohalm, J., Šubr, V., and Říhová, B. (1997) Synthesis of biodegradable polymers for controlled drug release. Ann. N. Y. Acad. Sci. 831, 47-56.
19. Jelínková, M., Strohalm, J., Plocová, D., Šubr, V., Št'astný, M., Ulbrich, K, and Říhová, B. (1998) Targeting of human and mouse T-lymphocytes by monoclonal antibody-HPMA copolymer-doxorubicin conjugates directed against different T-cell surface antigens. J. Controlled Release 52, 253-270.
20. 2-targeted conjugates and combined therapy with immunomodulators. J. Controlled Release (in press).