Digital microfluidic logic gates and their application to built-in self-test of lab-on-chip

IEEE Transactions on Biomedical Circuits and Systems

Volumn 4, Issue 4, 2010, Pages 250-262

  Zhao, Yang ^a   Chakrabarty, Krishnendu ^a  

^a Duke University   (United States)

Author keywords

Dependability; lab on chip; logic gates; microfluidics; testing

Indexed keywords

CAPACITIVE SENSING; DEPENDABILITY; DIGITAL MICROFLUIDICS; ERROR PRONES; LAB-ON-CHIP; LOW OVERHEAD; MULTIPLE TEST; NOT GATE; PULSE SEQUENCE ANALYSIS; SINGLE DROPLET; TEST METHOD; TESTING METHOD;

BIOASSAY; BUILT-IN SELF TEST; DROP FORMATION; LABORATORIES; LOGIC GATES;

MICROFLUIDICS;

EID: 77955176249     PISSN: 19324545     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBCAS.2010.2048567     Document Type: Article

References (35)

1. R. B. Fair, A. Khlystov, T. D. Tailor, V. Ivanov, R. D. Evans, V. Srinivasan, V. K. Pamula, M. G. Pollack, P. B. Griffin, and J. Zhou, "Chemical and biological applications of digital-microfluidic devices," IEEE Design Test Comput., vol.24, no.1, pp. 10-24, Jan. 2007.
2. K. Chakrabarty and F. Su, Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques. Boca Raton, FL: CRC, 2006.
3. M. G. Pollack, "Electrowetting-Based Microactuation of Droplets for Digital Microfluidics," Ph.D. dissertation, Duke Univ., Durham, NC, 2001.
4. Advanced Liquid Logic. [Online]. Available: http://www.liquidlogic. com
5. "Overview of the Berkeley sensor & actuator center," in Proc. Berkeley EECS Annu. Res. Symp., 2009. [Online]. Available: http://www.eecs. berkeley.edu/IPRO/BEARS/2009/pister.pdf
6. M. L. Bushnell and V. D. Agrawal, Essentials of Electronic Testing for Digital, Memory and Mixed-Signal VLSI Circuits. Norwell, MA: Kluwer, 2000.
7. S.-K. Fan, C. Hashi, and C.-J. Kim, "Manipulation of multiple droplets on N×M grid by cross-reference EWOD driving scheme," in Proc. Int. Conf. MEMS, 2003, pp. 694-697.
8. J.-Y. Yoon and R. L. Garrell, "Preventing biomolecular adsorption in electrowetting-based biofluidic chips," Anal. Chem., vol.75, pp. 5097-5102, 2003.
9. E. J. Griffith, S. Akella, and M. K. Goldberg, "Performance characterization of a reconfigurable planar-array digital microfluidic system," IEEE Trans. Comput. Aided Design, vol.25, no.2, pp. 345-357, Feb. 2006.
10. H. G. Kerkhoff, "Testing microelectronic biofluidic systems," IEEE Design Test Comput., vol.24, no.1, pp. 72-82, Jan./Feb. 2007.
11. X. Zhang, F. Proosdij, and H. G. Kerkhoff, "A droplet routing technique for fault-tolerant digital microfluidic devices," presented at the IEEE Int. Mixed-Signal, Sensors, and Systems Test Workshop, Vancouver, BC, Canada, 2008.
12. H. G. Kerkhoff and M. Acar, "Testable design and testing of micro-electrofluidic arrays," in Proc. IEEE VLSI Test Symp., 2003, pp. 403-409.
13. D. W. M. Marr and T. Munakata, "Micro/nanofluidic computing," Commun. ACM, vol.50, pp. 64-68, 2007.
14. M. Prakash and N. Gershenfeld, "Microfluidic bubble logic," Science, vol.315, pp. 832-835, 2007.
15. Q. Gayem, H. Liu, A. Richardson, and N. Burd, "Built-in test solutions for the electrode structures in bio-fluidic microsystems," in Proc. ETS, 2009, pp. 73-78.
16. A. J. Ricketts, K. Irick, N. Vijaykrishnan, and M. J. Irwin, "Priority scheduling in digital microfluidics-based biochips," in Proc. DATE Conf., 2006, pp. 329-334.
17. A. B. Fuchs, A. Romani, D. Freida, G. Medoro, M. Abonnenc, L. Altomare, I. Chartier, D. Guergour, C. Villiers, P. N. Marche, M. Tartagni, R. Guerrieri, F. Chatelain, and N. Manaresi, "Electronic sorting and recovery of single live cells from microlitre sized samples," Lab on a Chip, vol.6, pp. 121-126, 2006.
18. V. Srinivasan, V. K. Pamula, M. G. Pollack, and R. B. Fair, "Clinical diagnositics on human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital microfluidic platform," in Proc. MicroTAS, 2003, pp. 1287-1290.
19. V. Srinivasan et al., "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids," Lab on a Chip, vol.4, pp. 310-315, 2004.
20. F. Su and J. Zeng, "Computer-aided design and test for digital microfluidics," IEEE Design & Test of Computers, vol.24, no.1, pp. 60-70, Jan./Feb. 2007.
21. F. Su, W. Hwang, A. Mukherjee, and K. Chakrabarty, "Testing and diagnosis of realistic defects in digital microfluidic biochips," JETTA, vol.23, pp. 219-233, 2007. (Pubitemid 46866596)
22. F. Su, K. Chakrabarty, and R. B. Fair, "Microfluidics-based biochips: Technology issues, implementation platforms, and design automation challenges," IEEE Trans. Comput. Aided Design, vol.25, no.2, pp. 211-223, Feb. 2006.
23. F. Su, W. Hwang, A. Mukherjee, and K. Chakrabarty, "Defect-oriented testing and diagnosis of digital microfluidics-based biochips," in Proc. ITC, 2005, pp. 487-496. (Pubitemid 46287540)
24. M. Tartagni and R. Guerrieri, "A fingerprint sensor based on the feedback capacitive sensing scheme," IEEE J. Solid-State Circuits, vol.33, no.1, pp. 133-142, Jan. 1998.
25. V. Pless, Introduction to the Theory of Error-Correcting Codes. New York: Wiley, 1982.
26. T. Vestad, D. W. M. Marr, and T. Munakata, "Flow resistance for microfluidic logic operations," Appl. Phys. Lett., vol.84, no.25, pp. 5074-5075, 2004.
27. H. Moon, A. R. Wheeler, R. L. Garrell, J. A. Loo, and C.-J. Kim, "An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS," Lab on a Chip, vol.6, pp. 1213-1219, 2006.
28. P. H. Yuh, C. L. Yang, and C. W. Chang, "Placement of defect-tolerant digital microfluidic biochips using the T-tree formulation," ACM J. Emerging Tech. Computing Syst., vol.3, pp. 13.1-13.32, 2007.
29. W. Zhan and R. M. Crooks, "Microelectrochemical logic circuits," J. Am. Chem. Soc., vol.125, no.33, pp. 9934-9935, 2003.
30. T. Xu and K. Chakrabarty, "Parallel scan-like test and multiple-defect diagnosis for digital microfluidic biochips," IEEE Trans. Biomed. Circuits Syst., vol.1, no.2, pp. 148-158, Jun. 2007. (Pubitemid 350141715)
31. T. Xu and K. Chakrabarty, "Fault modeling and functional test methods for digital microfluidic biochips," IEEE Trans. Biomed.Circuits Syst., vol.3, no.4, pp. 241-253, Aug. 2009.
32. T. Xu, K. Chakrabarty, and V. K. Pamula, "Design and optimization of a digital microfluidic biochip for protein crystallization," in Proc. ICCAD, 2008, pp. 297-301.
33. T. Xu and K. Chakrabarty, "Design-for-testability for digital microfluidic biochips," in Proc. IEEE VLSI Test Symp., 2009, pp. 309-314.
34. T. Xu and K. Chakrabarty, "Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips," in Proc. DAC, 2008, pp. 173-178.
35. T. Xu et al., "Automated design of pin-constrained digital microfluidic biochips under droplet-interference constraints," ACMJ. Emerging Tech. in Computing Syst., vol.3, 2007, article 14.