Goniothalamin induces coronary artery smooth muscle cells apoptosis: The p53-dependent caspase-2 activation pathway

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 533-548

  Chan, Kok Meng ^a   Rajab, Nor Fadilah ^a   Siegel, David ^b   Din, Laily Bin ^a   Ross, David ^b   Inayat Hussain, Salmaan Hussain ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Caspases; Coronary artery smooth muscle cells; Goniothalamin; Mitochondrial mediated apoptosis; NQO1; P53

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 2; CASPASE 8; CASPASE 9; CYTOCHROME C; GONIOTHALAMIN; HERBACEOUS AGENT; HYDROGEN PEROXIDE; PHOSPHATIDYLSERINE; PROTEIN MDM2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; NQO1 PROTEIN, HUMAN; PEPTIDE CHLOROMETHYL KETONE; PYRONE DERIVATIVE; SUPEROXIDE;

APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; CORONARY ARTERY SMOOTH MUSCLE CELL; CYTOTOXICITY; DNA DAMAGE; DRUG ELUTING STENT; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GONIOTHALAMUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); TOXICITY; VASCULAR SMOOTH MUSCLE;

ADENOSINE TRIPHOSPHATE; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASE 2; CELLS, CULTURED; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NAD(P)H DEHYDROGENASE (QUINONE); OXYGEN CONSUMPTION; PYRONES; SUPEROXIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955098397     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq151     Document Type: Article

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