An interpretation of positional displacement of the helix12 in nuclear receptors: Preexistent swing-up motion triggered by ligand binding

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1804, Issue 9, 2010, Pages 1832-1840

  Watanabe, Chiduru ^a,b   Watanabe, Hirofumi ^a,c   Tanaka, Shigenori ^a,c  

^a KOBE UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Allosteric effect; Helix 12; Moleculardynamics (MD)Linear response theory; Nuclear receptor; Protein structural change

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTRADIOL; HYDROXYTAMOXIFEN; LIGAND; TAMOXIFEN;

ARTICLE; BIOLOGICAL ACTIVITY; CALCULATION; HELIX 12; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SIMULATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM;

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; TAMOXIFEN;

EID: 77955093455     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2010.06.009     Document Type: Article

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