Tuning somatic hypermutation by transcription

Current Topics in Microbiology and Immunology

Volumn 246, Issue , 1999, Pages 149-159

  Jacobs, H ^a   Puglisi, A ^a   Rajewsky, K ^b   Fukita, Y ^b,c  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF COLOGNE   (Germany)

^c HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RNA POLYMERASE;

B LYMPHOCYTE; CONFERENCE PAPER; GENE MUTATION; GENE REARRANGEMENT; GERMINAL CENTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0032931486     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-60162-0_19     Document Type: Conference Paper

References (10)

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2. Aoufouchi S, Yelamos J, Milstein C (1996) Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis. Cell 85:415-422
3. Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger M S (1994) Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239-248
4. Betz AG, Neuberger MS, Milstein C (1993) Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14: 405-411
5. Cheng J, Maquat L E (1993) Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol 13:1892-1902
6. Fukita Y, Jacobs H, Rajewsky K (1998) Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription. Immunity 9: 105-114
7. Gonzalez-Fernandez A, Gupta SK, Pannell R, Neuberger MS, Milstein C (1994) Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc Natl Acad Sci U S A 91:12614-12618
8. Goyenechea B, Klix N, Yelamos J, Williams GT, Riddell A, Neuberger MS, Milstein C (1997) Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. Embo J 16:3987-3994
9. Grummt I, Skinner JA. (1985) Efficient transcription of a protein-coding gene from the RNA polymerase I promoter in transfected cells. Proc Natl Acad Sci U S A 82:722-726
10. Jacobs H, Fukita Y, van der Horst GTJ, de Boer J, Weeda G, Essers J, de Wind N, Engelward BP, Samson L, Verbeek S, Ménissier de Murcia J, de Murcia G, te Riele H, Rajewsky K (1998) Hypermutation of Immunoglobulin Genes in Memory B cells of DNA repair-deficient Mice. J Exp Med 187:1735-1743