Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway

Food Chemistry

Volumn 123, Issue 4, 2010, Pages 1062-1075

  Ghosh, Jyotirmoy ^a   Das, Joydeep ^a   Manna, Prasenjit ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Anti oxidant; Apoptosis; Cadmium; Hepatic disorder; Hepatoprotection; Oxidative impairment; Terminalia arjuna fruit

Indexed keywords

ALANINE AMINOTRANSFERASE; ARJUNOLIC ACID; CADMIUM; CASPASE 3; CATALASE; FLAVONOID; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; GLYCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SAPONIN; SUPEROXIDE DISMUTASE; TANNIN; TERMINALIA ARJUNA EXTRACT; TERPENOID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BARK; BODY GROWTH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; LIPID PEROXIDATION; LIVER CELL; LIVER CELL DAMAGE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SCAVENGING SYSTEM; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE;

MURINAE; MUS; TERMINALIA ARJUNA;

EID: 77954952873     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2010.05.062     Document Type: Article

References (37)

1. Bauman J.W., Liu J., Klaassen C.D. Production of metalothionein and heat-shock proteins in response to metals. Fundamental and Applied Toxicology 1993, 21:15-22.
2. Boham B.A., Kocipal-Abyazan R. Flavonoids and condensed tannins from leaves of Hawaiian vaccinium vaticulatum and V. Calycinum. Pacific Science 1974, 48:458-463.
3. Casalino E., Calzaretti G., Sblano C., Landriscina C. Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 2002, 179:37-50.
4. Devi R.S., Narayan S., Vani G., Devi C.S. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chemico Biological Interaction 2007, 167:41-83.
5. Edeoga H.O., Okwu D.E., Mbaebie B.O. Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology 2005, 4:685-688.
6. Ellman G.L. Tissue sulfhydryl group. Archives of Biochemistry and Biophysics 1959, 82:70-77.
7. Feuerstein G.Z., Young P.R. Apoptosis in cardiac diseases: stress- and mitogen activated signaling pathways. Cardiovascular Research 2000, 45:560-569.
8. Finck B.N., Han X., Courtois M., Aimond F., Nerbonne J.M., Kovacs A., et al. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content. Proceedings of the National Academy of Sciences 2003, 100:1226-1231.
9. Gao H.B., Tong M.H., Hu Y.Q., You H.Y., Guo Q.S., Ge R.S., et al. Mechanisms of glucocorticoid-induced Leydig cell apoptosis. Molecular and Cellular Endocrinology 2003, 199:153-163.
10. Ghosh J., Das J., Manna P., Sil P.C. Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicology In Vitro 2008, 22:1918-1926.
11. Ghosh J., Das J., Manna P., Sil P.C. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway. Toxicology and Applied Pharmacology 2009, 240:73-87.
12. Ghosh J., Das J., Manna P., Sil P.C. Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP) induced liver and hepatocytes injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. Free Radical Biology and Medicine 2010, 48:535-553.
13. Ghosh J., Das J., Manna P., Sil P.C. Acetaminophen induced renal injury via oxidative stress and TNF-α production: Therapeutic potential of arjunolic acid. Toxicology 2010, 268:8-18.
14. Haque M.Z., Saki M.A., Ali M.U., Ali M.Y., Maruf M.A. Investigations on Terminalia arjuna fruits: Part 1 - Isolation of compounds from petroleum ether fractions. Bangladesh Journal Scientific and Industrial Research 2008, 43:123-130.
15. Haque M.Z., Saki M.A., Ali M.U., Ali M.Y., Maruf M.A. Investigations on Terminalia arjuna fruits: Part 2 - Isolation of compounds from ethyl acetate fractions. Bangladesh Journal Scientific and Industrial Research 2008, 43(1):283-290.
16. Harborne J.B. Phytochemical methods: A guide to modern techniques of plant analysis 1973, Chapman and Hall, New York, p. 279.
17. Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
18. Kapoor L.D., Singh A., Kapoor S.L., Shrivastava S.N. Survey of Indian medicinal plants for saponins, alkaloids and flavonoids. Lloydia 1969, 32:297-302.
19. Kaur K., Kumar S., Nagpal A. Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna. Food and Chemical Toxicology 2002, 40:1475-1482.
20. Keeble J.A., Gilmore A.P. Apoptosis commitment-translating survival signals into decisions on mitochondria. Cell Research 2007, 17:976-984.
21. Kiritiker, K. R., & Basu, B. D. (1987). Indian medicinal plants (Vol. 2, 2nd ed., pp. 1023-1028). India: International Book Distributors Publications.
22. Kiritiker K.R., Basu B.D. Indian Medicinal Plants 1935, Vol. I:544-547. Probasi Press, Calcutta.
23. Kolawole O.M., Oguntoye S.O., Agbede O., Olayemi A.B. Studies on the efficacy of Bridelia ferruginea Benth. Bark extract in reducing the coliform load and BOD of domestic waste water. Ethnobotanical leaflets 2006, 10:228-238.
24. Li W., Zhao Y., Chou I.N. Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions. Toxicology 1993, 77:65-79.
25. Manna P., Sinha M., Sil P.C. Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 2009, 257:53-63.
26. McDonald S., Prenzler P.D., Autolovich M., Robards K. Phenolic content and anti-oxidant activity of olive extract. Food Chemistry 2001, 73:73-84.
27. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. Journal of Natural Product 2007, 70:461-477.
28. Obadoni B.O., Ochuko P.O. Phytochemical studies and comparative efficacy of crude extracts of some homeostatic plants in Edo and Delta States of Nigeria. Global Journal of Pure Applied Sciences 2001, 8:203-208.
29. Pope A., Rall D.P. Environmental medicine. Integrating a missing element into medical education 1995, National Academy Press, Washington, DC, pp. 230-231.
30. Scassellati-Sforzolini G., Villarini L.M., Moretti L.M., et al. Antigenotoxic properties of Terminalia arjuna (TA) bark extracts. Journal of Environmental Pathology Toxicology Oncology 1999, 18:119-125.
31. Sing D.V., Verma R.K., Sing S.C., Gupta M.M. RP-LC determination of oleane derivatives in Terminalia arjuna. Journal of Pharmaceutical and Biomedical Analysis 2002, 28:447-452.
32. Slater T.F. Free radical mechanism in tissue injury. Biochemical Journal 1984, 222:1-15.
33. Szuster-Ciesielska A., Stachura A., Slotwinska M., Kaminska T., Sneizko R., Paduch R., et al. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 2000, 145:159-171.
34. 2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase. Toxicology 2001, 157:167-175.
35. Yamanaka K., Hesegwa A., Sawamuna R., Okada S. Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice. Toxicology and Applied Pharmacology 1991, 108:205-213.
36. Yemm E.W., Willis A.J. The estimation of carbohydrates in plant extracts by anthrone. Biochemical Journal 1954, 57:508-514.
37. Yokozawa T., Chen C.P., Dong E., Tanaka T., Nonaka G.I., Nishioka I. Study on the inhibitory effect of tannins and flavonoids against the 1,1-diphenyl-2-picrylhydrazyl radical. Biochemical Pharmacology 1998, 56:213-222.