Zn2+ and Cd2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase

Toxicology

Volumn 157, Issue 3, 2001, Pages 167-175

  Wätjen, Wim ^a   Benters, Jelko ^a   Haase, Hajo ^a   Schwede, Frank ^a   Jastorff, Bernd ^a   Beyersmann, Detmar ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

Cadmium; Guanosine 3 ,5 cyclic monophosphate; PC12 cells; Phosphodiesterase; Zinc

Indexed keywords

CADMIUM; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ZINC; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SYNTHESIS; HYDROLYSIS; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL STRAIN; DOSE RESPONSE; DRUG ANTAGONISM;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CADMIUM; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; PC12 CELLS; RATS; ZINC;

EID: 0035951285     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00370-X     Document Type: Article

References (41)

1. In vitro cytotoxicity testing of aquatic pollutants (cadmium, copper, zinc, nickel) using established fish cell lines
2. Nitric oxide mediates intracytoplasmatic and intranuclear zinc release
3. Cadmium, gene regulation and cellular signalling in mammalian cells
4. Cadmium(II) specifically interacts with cellular signaling to induce proto-oncogenes c-fos and c-jun in rat PC12 cells
5. 2+ channel currents through protein phospororylationin rat pinealocytes
6. 2+ release and influx responses in PC12-64 cells
7. Effects of thiol inhibitors on hepatic guanylate cyclase activity
8. Guanylate cyclase and the NO/cGMP signaling pathway
9. Nitric oxide reduces depolarization-induced calcium influx in PC12 cells by a cyclic GMP-mediated mechanism
10. Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis
11. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
12. Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-fos and junB in PC12 cells
13. Apoptosis induced by cadmium
14. 2+)-ATPase by Zn(II)
15. Cadmium uptake and toxicity via voltage-sensitive calcium channels
16. Cadmium toxicity in rat pheochromocytoma cells: Studies on the mechanism of uptake
17. Structure and physiological role of cGMP-dependent protein kinase
18. Beryllium, cadmium, mercury, and exposures in glass manufacturing industry
19. Health effects of cadmium exposure - A review of the literature and a risk estimate
20. Cadmium induces transcription of proto-oncogenes, c-jun and c-myc in rat L6 myoblasts
21. cGMP levels in chronic cadmium disease and osteoarthritis
22. 2+-mobilization in rat phaechromocytoma cells
23. Nerve growth factor increases the cyclic GMP phosphodiesterase in PC12 cells
24. Amino acid sequence of the cGMP stimulated cyclic nucleotide phosphodiesterase from bovine heart
25. Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact cells
26. Evidence that nitric oxide enhances cadmium toxicity by displacing the metal from metallothionein
27. Nitric oxide and cell death
28. A simple, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences
29. Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney
30. 2+ ion
31. Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells
32. Cadmium uptake and interference with receptor-mediated calcium mobilization in PC12 cells
33. Transient peaks in zinc and metallothionein levels during differentiation of 3T3L1 cells
34. Cadmium evokes inositol polyphosphate formation and calcium mobilisation
35. Lead- and calcium-mediated inhibition of bovine rod cGMP phosphodiesterase: Interactions with magnesium
36. The influence of zinc on apoptosis
37. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: Lead, nickel, and cobalt utilize different mechanisms
38. The biochemical basis of zinc physiology
39. Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system
40. Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells
41. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation