Immunomodulatory effects of honey cannot be distinguished from endotoxin

Cytokine

Volumn 42, Issue 1, 2008, Pages 113-120

  Timm, Michael ^a   Bartelt, Stine ^a   Hansen, Erik Wind ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

IL 6; Immunomodulation; LPS; ROS; Wound healing

Indexed keywords

ENDOTOXIN; IMMUNOMODULATING AGENT; INTERLEUKIN 6; POLYMYXIN B; REACTIVE OXYGEN METABOLITE;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; HONEY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOMODULATION; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL;

ANIMALS; CELL LINE; ENDOTOXINS; GRANULOCYTES; HONEY; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; MONOCYTES; POLYMYXIN B; WOUND HEALING;

EID: 41149163067     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2008.01.005     Document Type: Article

References (16)

1. Cooper R.A., Molan P.C., and Harding K.G. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J R Soc Med 92 (1999) 283-285
2. French V.M., Cooper R.A., and Molan P.C. The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother 56 (2005) 228-231
3. Molan P.C. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2 (2001) 13-19
4. Lusby P.E., Coombes A., and Wilkinson J.M. Honey: a potent agent for wound healing?. J Wound Ostomy Continence Nurs 29 (2002) 295-300
5. Molan P.C. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 5 (2006) 40-54
6. Moore O.A., Smith L.A., Campbell F., Seers K., McQuay H.J., and Moore R.A. Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med 1 (2001) 2
7. Tonks A.J., Cooper R.A., Jones K.P., Blair S., Parton J., and Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine 21 (2003) 242-247
8. Tonks A., Cooper R.A., Price A.J., Molan P.C., and Jones K.P. Stimulation of TNF-alpha release in monocytes by honey. Cytokine 14 (2001) 240-242
9. Timm M., Hansen E.W., Moesby L., and Christensen J.D. Utilization of the human cell line HL-60 for chemiluminescence based detection of microorganisms and related substances. Eur J Pharm Sci 27 (2006) 252-258
10. Council of Europe. Bacterial endotoxins. Ph Eur; 2005: p 161-9, [Chapter 2.6.14.].
11. Ziegler-Heitbrock H.W., Thiel E., Futterer A., Herzog V., Wirtz A., and Riethmuller G. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int J Cancer 41 (1988) 456-461
12. Moesby L., Hansen E.W., and Christensen J.D. Pyrogen testing of lipid-based TPN using Mono Mac 6 monocyte cell line and DELFIA. J Clin Pharm Ther 22 (1997) 327-333
13. Tsuzuki H., Tani T., Ueyama H., and Kodama M. Lipopolysaccharide: neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappaB in peripheral blood mononuclear cells, even during activation. J Surg Res 100 (2001) 127-134
14. Moesby L., Jensen S., Hansen E.W., and Christensen J.D. A comparative study of Mono Mac 6 cells, isolated mononuclear cells and Limulus amoebocyte lysate assay in pyrogen testing. Int J Pharm 191 (1999) 141-149
15. Kjeldsen T.H., Hansen E.W., Christensen J.D., and Moesby L. Baclofen influences lipopolysaccharide-mediated interleukin-6 release from murine pituicytes. Eur J Pharmacol 451 (2002) 209-215
16. Tonks A.J., Dudley E., Porter N.G., Parton J., Brazier J., Smith E.L., and Tonks A. A 5.8-kDa component of Manuka honey stimulates immune cells via TLR4. J Leukoc Biol 82 5 (2007) 1147-1155