Promotion of incisional wound repair by human mesenchymal stem cell transplantation

Experimental Dermatology

Volumn 18, Issue 4, 2009, Pages 362-369

  Stoff, Alexander ^a,b,c   Rivera, Angel A ^a   Banerjee, N Sanjib ^d   Moore, Steven T ^e   Numnum, T Michael ^a   Espinosa de los Monteros, Antonio ^b   Richter, Dirk F ^b   Siegal, Gene P ^a   Chow, Louise T ^d   Feldman, Dale ^e   Vasconez, Luis O ^c   Mathis, J Michael ^f   Stoff Khalili, Mariam A ^a,g   Curiel, David T ^a  

^a University of Alabama at Birmingham   (United States)

^b Dreifaltigkeits Hospital   (Germany)

^c Kentucky   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e and Radiation Oncology   (United States)

^f LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^g HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Incisional wounds; Mesenchymal stem cells; Scar formation; Tensile strength; Wound healing

Indexed keywords

CARBOCYANINE; PHOSPHATE BUFFERED SALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INCISION; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; RABBIT; SCAR FORMATION; SKIN INJURY; SKIN TENSION; SKINFOLD THICKNESS; TENSILE STRENGTH; WOUND HEALING;

ANIMALS; CICATRIX; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MODELS, ANIMAL; RABBITS; SKIN; TENSILE STRENGTH; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS; WOUND HEALING;

EID: 63149124798     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00792.x     Document Type: Article

References (33)

1. Badiavas E V, Abedi M, Butmarc J et al. Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 2003: 196: 245-250.
2. Singer A J, Clark R A. Cutaneous wound healing. N Engl J Med 1999: 341: 738-746.
3. Barry F P, Murphy J M. Mesenchymal stem cells: Clinical applications and biological characterization. Int J Biochem Cell Biol 2004: 36: 568-584.
4. Prockop D J, Gregory C A, Spees J L. One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci USA 2003: 100 (Suppl. 1): 11917-11923.
5. Mansilla E, Marin G H, Sturla F et al. Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries. Transplant Proc 2005: 37: 292-294.
6. Spees J L, Olson S D, Ylostalo J et al. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci USA 2003: 100: 2397-2402.
7. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001: 410: 701-705.
8. Ortiz L A, Gambelli F, McBride C et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003: 100: 8407-8411.
9. Teng Y D, Lavik E B, Qu X et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002: 99: 3024-3029.
10. Sekiya I, Larson B L, Smith J R, Pochampally R, Cui J G, Prockop D J. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002: 20: 530-541.
11. Prockop D J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997: 276: 71-74.
12. Hebda P A, Dohar J E. Transplanted fetal fibroblasts: Survival and distribution over time in normal adult dermis compared with autogenic, allogenic, and xenogenic adult fibroblasts. Otolaryngol Head Neck Surg 1999: 121: 245-251.
13. Culling C.F.A. Handbook of Histopathological and Histochemical Techniques (Including Museum Technique), (3rd ed.), London: Butterworth and Co. Ltd, 1974, pp. 187-220.
14. Liechty K W, Nesbit M, Herlyn M, Radu A, Adzick N S, Crombleholme T M. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing. J Invest Dermatol 1999: 113: 375-383.
15. Singer A J, Thode H C Jr, McClain S A. Development of a histomorphologic scale to quantify cutaneous scars after burns. Acad Emerg Med 2000: 7: 1083-1088.
16. Hunt T K. Basic principles of wound healing. J Trauma 1990: 30: S122-S128.
17. Jiang Y, Jahagirdar B N, Reinhardt R L et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002: 418: 41-49.
18. Swanson N A, Tromovitch T A. Suture materials, 1980s: Properties, uses, and abuses. Int J Dermatol 1982: 21: 373-378.
19. Singer D D, Singer A J, McClain S A, Tortora G. Histologic effects of laser-assisted topical anesthesia in a porcine model. Acad Emerg Med 2005: 12: 1148-1152.
20. Bartholomew A, Sturgeon C, Siatskas M et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002: 30: 42-48.
21. Di Nicola M, Carlo-Stella C, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002: 99: 3838-3843.
22. Tse W T, Pendleton J D, Beyer W M, Egalka M C, Guinan E C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implication in transplantation. Transplantation 2003: 75: 389-397.
23. Krampera M, Glennie S, Dyson J et al. Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide. Blood 2003: 101: 3722-3729.
24. Liu H, Kemeny D M, Heng B C, Ouyang H W, Melendez A J, Cao T. The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells. J Immunol 2006: 176: 2864-2871.
25. Ronsyn M W, Daans J, Spaepen G, Chatterjee S et al. Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord. BMC Biotechnol 2007: 7: 90.
26. Wang Y, Chen X, Armstrong M A, Li G. Survival of bone marrow-derived mesenchymal stem cells in a xenotransplantation model. J Orthop Res 2007: 25: 926-932.
27. Lawrence W T. Physiology of the acute wound. Clin Plast Surg 1998: 25: 321-340.
28. Yamamoto M, Yanaga H, Nishina H, Watabe S, Mamba K. Fibrin stimulates the proliferation of human keratinocytes through the autocrine mechanism of transforming growth factor-alpha and epidermal growth factor receptor. Tohoku J Exp Med 2005: 207: 33-40.
29. Nakagawa H, Akita S, Fukui M, Fujii T, Akino K. Human mesenchymal stem cells successfully improve skin-substitute wound healing. Br J Dermatol 2005: 153: 29-36.
30. Francois S, Mouiseddine M, Mathieu N et al. Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model. Ann Hematol 2007: 86: 1-8.
31. Stoff A, Rivera A A, Mathis J M et al. Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds. J Mol Med 2007: 85: 481-496.
32. Ong C T, Khoo Y T, Mukhopadhyay A et al. mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Exp Dermatol 2007: 16: 394-404.
33. Fumagalli M, Musso T, Vermi W et al. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Exp Dermatol 2007: 16: 600-610.