Monocyte chemoattractant protein-1 is generated via TGF-β by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection

Cancer Science

Volumn 101, Issue 8, 2010, Pages 1783-1789

  Mutoh, Hiroyuki ^a   Sashikawa, Miho ^a   Hayakawa, Hiroko ^a   Sugano, Kentaro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GASTRITIS; GENE OVEREXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MACROPHAGE; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA ISOLATION; STOMACH CARCINOMA; TRANSGENIC MOUSE; UPREGULATION;

ACTINS; ANIMALS; CHEMOKINE CCL2; FEMALE; FIBROBLASTS; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; METAPLASIA; MICE; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77954853797     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01609.x     Document Type: Article

References (45)

1. Baggiolini M, Loetscher P, Moser B. Interleukin-8 and the chemokine family. Int J Immunopharmacol 1995, 17:103-8.
2. Watanabe N, Shimada T, Ohtsuka Y, Hiraishi H, Terano A. Proinflammatory cytokines and Helicobacter pylori stimulate CC-chemokine expression in gastric epithelial cells. J Physiol Pharmacol 1997, 48:405-13.
3. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991, 32:1473-7.
4. Noach LA, Bosma NB, Jansen J, Hoek FJ, van Deventer SJ, Tytgat GN. Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol 1994, 29:425-9.
5. Jung HC, Kim JM, Song IS, Kim CY. Helicobacter pylori induces an array of pro-inflammatory cytokines in human gastric epithelial cells: quantification of mRNA for interleukin-8, -1 alpha/beta, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1 and tumour necrosis factor-alpha. J Gastroenterol Hepatol 1997, 12:473-80.
6. Ohta M, Kitadai Y, Tanaka S. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int J Cancer 2002, 102:220-4.
7. Ohta M, Kitadai Y, Tanaka S. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol 2003, 22:773-8.
8. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992, 52:6735-40.
9. Correa P, Fox J, Fontham E. Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks. Cancer 1990, 66:2569-74.
10. Mutoh H, Hakamata Y, Sato K. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 2002, 294:470-9.
11. Mutoh H, Satoh K, Kita H. Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine. Int J Dev Biol 2005, 49:867-71.
12. Mutoh H, Sakurai S, Satoh K. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004, 64:7740-7.
13. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-8.
14. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002, 420:860-7.
15. Mutoh H, Sakurai S, Satoh K. Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut 2004, 53:1416-23.
16. Yoshimura H, Nakahama K, Safronova O, Tanaka N, Muneta T, Morita I. Transforming growth factor-beta stimulates IL-1beta-induced monocyte chemoattractant protein-1 expression in human synovial cells via the ERK/AP-1 pathway. Inflamm Res 2006, 55:543-9.
17. Ma J, Wang Q, Fei T, Han JD, Chen YG. MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood 2007, 109:987-94.
18. Zhang F, Tsai S, Kato K. Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem 2009, 284:17564-74.
19. Wilson TJ, Nannuru KC, Futakuchi M, Singh RK. Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1. Cancer Lett 2010, 288:162-9.
20. Sidell N, Feng Y, Hao L. Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells. Mol Endocrinol 2010, 24:148-60.
21. Tokuda H, Hatakeyama D, Akamatsu S. Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts. Arch Biochem Biophys 2003, 415:117-25.
22. Yamamoto T, Kozawa O, Tanabe K. Involvement of p38 MAP kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells. J Cell Biochem 2001, 82:591-8.
23. Guan X, Zhao H, Niu J, Tang D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol 2009, 9:77.
24. Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res 2009, 28:94.
25. Szardening-Kirchner C, Konrad L, Hauck EW, Haag SM, Eickelberg O, Weidner W. Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie's disease. World J Urol 2009, 27:123-30.
26. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998, 67:753-91.
27. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-84.
28. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993, 122:103-11.
29. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res 2002, 8:2912-23.
30. Ronnov-Jessen L, Petersen OW, Bissell MJ. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996, 76:69-125.
31. Coffey RJ, Shipley GD, Moses HL. Production of transforming growth factors by human colon cancer lines. Cancer Res 1986, 46:1164-9.
32. Roberts AB, Sporn MB, Assoian RK. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986, 83:4167-71.
33. Mutoh H, Sakurai S, Satoh K. Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. Gut 2005, 54:33-9.
34. Mahida YR, Beltinger J, Makh S. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am J Physiol 1997, 273:G1341-8.
35. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999, 277:C1-9.
36. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 1999, 277:C183-201.
37. Sappino AP, Schurch W, Gabbiani G. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 1990, 63:144-61.
38. Jobson TM, Billington CK, Hall IP. Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation. J Clin Invest 1998, 101:2650-7.
39. Okuno T, Andoh A, Bamba S. Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts. Scand J Gastroenterol 2002, 37:317-24.
40. Hata K, Andoh A, Shimada M. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 2002, 282:G1035-44.
41. Salcedo R, Ponce ML, Young HA. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 2000, 96:34-40.
42. Fuentes ME, Durham SK, Swerdel MR. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. J Immunol 1995, 155:5769-76.
43. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001, 357:539-45.
44. Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med 2000, 248:171-83.
45. Ishigami S, Natsugoe S, Tokuda K. Tumor-associated macrophage (TAM) infiltration in gastric cancer. Anticancer Res 2003, 23:4079-83.