Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: Comparative study with Cdx2 transgenic mice

Gut

Volumn 53, Issue 10, 2004, Pages 1416-1423

  Mutoh, H ^a   Sakurai, S ^a   Satoh, K ^a   Osawa, H ^a   Hakamata, Y ^a   Takeuchi, T ^b   Sugano, K ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLINE; GASTRIN; HOMEODOMAIN PROTEIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CDX GENE; CDX2 HOMEOBOX GENE; GENE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH MUCOSA; TRANSGENIC MOUSE;

ANIMALS; GASTRIC MUCOSA; HOMEODOMAIN PROTEINS; METAPLASIA; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 4644346431     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.032482     Document Type: Article

References (35)

1. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999;80:827-41.
2. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965;64:31-49.
3. Correa P. A human model of gastric carcinogenesis. Cancer Res 1988;48:3554-60.
4. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992;52:6735-40.
5. Correa PSY. Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 1994;54(suppl):1941s-3.
6. Meyer BI, Gruss P. Mouse cdx-1 expression during gastrulation. Development 1993;117:191-203.
7. Silberg DG, Swain GB, Suh ER, et al. Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 2000;119:961-71.
8. Silberg DG, Furth EE, Taylor JK, et al. CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 1997;113:478-86.
9. Mizoshita T, Inada K, Tsukamoto T, et al. Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa - with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 2001;4:185-91.
10. Eda A, Osawa H, Yanaka I, et al. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 2002;37:94-100.
11. Satoh K, Mutoh H, Eda A, et al. Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. Helicobacter 2002;7:192-8.
12. Bai YQ, Yamamoto H, Akiyama Y, et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 2002;176:47-55.
13. Almeida R, Silva E, Santos-Silva F, et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003;199:36-40.
14. Mutoh H, Hakamata Y, Sato K, et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 2002;294:470-9.
15. Silberg DG, Sullivan J, Kang E, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002;122:689-96.
16. Duprey P, Chowdhury K, Dressler GR, et al. A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes Dev 1988;2:1647-54.
17. James R, Erler T, Kazenwadel J. Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium. J Biol Chem 1994;269:15229-37.
18. Subramanian V, Meyer B, Evans GS. The murine Cdx1 gene product localises to the proliferative compartment in the developing and regenerating intestinal epithelium. Differentiation 1998;64:11-18.
19. Hogan B, Beddington R, Costantini F, et al. Manipulating the mouse embryo: a laboratory manual, 2nd edn. New York: Cold Spring Harbor Laboratory Press, 1994.
20. Canfield V, West AB, Goldenring JR, et al. Genetic ablation of parietal cells in transgenic mice: A new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci USA 1996;93:2431-5.
21. Li Q, Karam SM, Gordon JI. Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice. J Biol Chem 1996;271:3671-6.
22. Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am J Anat 1974;141:461-79.
23. Potten CS, Allen TD. Ultrastructure of cell loss in intestinal mucosa. J Ultrastruct Res 1977;60:272-7.
24. Wright NA, Irwin M. The kinetics of villus cell populations in the mouse small intestine. I. Normal villi: the steady state requirement, Cell Tissue Kinet 1982;15:595-609.
25. Cheng H. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am J Anat 1974;141:521-35.
26. Soubeyran P, Andre F, Lissitzky JC, et al. Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 1999;117:1326-38.
27. Traber PG. Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine. Biochem Biophys Res Commun 1990;173:765-73.
28. Traber PG, Yu L, Wu GD, et al. Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance. Am J Physiol 1992;262:G123-30.
29. Rings EH, Krasinski SD, van Beers EH, et al. Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development. Gastroenterology 1994;106:1223-32.
30. Rings EH, Boudreau F, Taylor JK, et al. Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 2001;121:1437-50.
31. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996;16:619-25.
32. Batlle E, Henderson JT, Beghtel H, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-63.
33. Oh EJ, Park JH, Cho M, et al. The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells. Int J Oncol 2002;20:23-9.
34. Soubeyran P, Haglund K, Garcia S, et al. Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells. Oncogene 2001;20:4180-7.
35. Maulbecker CC, Gruss P. The oncogenic potential of deregulated homeobox genes. Cell Growth Differ 1993;4:431-41.