The crystal structure of the green tea polyphenol (-)-Epigallocatechin gallate?transthyretin complex reveals a novel binding site distinct from the thyroxine binding site

Biochemistry

Volumn 49, Issue 29, 2010, Pages 6104-6114

  Miyata, Masanori ^a   Sato, Takashi ^a   Kugimiya, Miyuki ^a   Sho, Misato ^a   Nakamura, Teruya ^a   Ikemizu, Shinji ^a   Chirifu, Mami ^a   Mizuguchi, Mineyuki ^b   Nabeshima, Yuko ^b   Suwa, Yoshiaki ^a   Morioka, Hiroshi ^a   Arimori, Takao ^a   Suico, Mary Ann ^a   Shuto, Tsuyoshi ^a   Sako, Yasuhiro ^a   Momohara, Mamiko ^a   Koga, Tomoaki ^a   Morino Koga, Saori ^a   Yamagata, Yuriko ^a   Kai, Hirofumi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FIBRIL; AMYLOID FIBRIL FORMATION; CELLULAR SYSTEM; EPIGALLOCATECHIN GALLATE; EXTRACELLULAR ENVIRONMENTS; GALLATE; GREEN TEA; GREEN TEA POLYPHENOLS; HUMAN PLASMA PROTEINS; MODE OF ACTION; NEURODEGENERATIVE DISEASE; POINT MUTATIONS; POLYNEUROPATHY; POLYPHENOLS; PROTEIN MISFOLDING; TETRAMERS; TRANSTHYRETIN;

BINDING ENERGY; BIOCHEMISTRY; CHEMICAL COMPOUNDS; CRYSTAL STRUCTURE; GLYCOPROTEINS; OLIGOMERIZATION; PROTEINS; STRUCTURAL ANALYSIS;

BINDING SITES;

AMYLOID; EPIGALLOCATECHIN GALLATE; MONOMER; POLYPHENOL; PREALBUMIN; TETRAMER; THYROXINE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; FAMILIAL AMYLOID POLYNEUROPATHY; HUNTINGTON CHOREA; MOLECULAR STABILITY; NONHUMAN; OLIGOMERIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN VARIANT; TEA;

AMYLOID NEUROPATHIES, FAMILIAL; BINDING SITES; CAMELLIA SINENSIS; CATECHIN; CRYSTALLOGRAPHY, X-RAY; FLAVONOIDS; HUMANS; PHENOLS; PREALBUMIN; PROTEIN CONFORMATION; THYROXINE;

EID: 77954847105     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1004409     Document Type: Article

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