The crystal structure of amyloidogenic Leu55 → Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils

Journal of Biological Chemistry

Volumn 273, Issue 38, 1998, Pages 24715-24722

  Sebastião, Maria Paula ^b   Saraiva, Maria João ^a,b   Damas, Ana Margarida ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; PREALBUMIN;

AMINO ACID SUBSTITUTION; AMYLOIDOSIS; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN POLYMERIZATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMYLOID NEUROPATHIES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; LEUCINE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POINT MUTATION; PREALBUMIN; PROLINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; VARIATION (GENETICS);

GENETTA;

EID: 0032544408     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.38.24715     Document Type: Article

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