A design and evaluation of layered matrix tablet formulations of metoprolol tartrate

AAPS PharmSciTech

Volumn 11, Issue 2, 2010, Pages 563-573

  Baloğlu, Esra ^a   Şenyiğit, Taner ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

Carrageenan; Layered matrix tablet; Metoprolol tartrate; Stability; Target profile

Indexed keywords

CARRAGEENAN; CHITOSAN; ETHYL CELLULOSE; GUAR GUM; HYDROXYPROPYLMETHYLCELLULOSE; METOPROLOL TARTRATE; PECTIN; XANTHAN; ANTIARRHYTHMIC AGENT; DRUG CARRIER; METOPROLOL; POLYMER; TABLET;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; HARDNESS; HUMAN; HUMIDITY; IN VITRO STUDY; MATRIX TABLET; PRIORITY JOURNAL; THICKNESS; WEIGHT; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DIFFUSION; DRUG SCREENING; PROCEDURES; SYNTHESIS; TABLET; YOUNG MODULUS;

ANTI-ARRHYTHMIA AGENTS; COMPUTER SIMULATION; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ELASTIC MODULUS; HARDNESS; METOPROLOL; MODELS, CHEMICAL; POLYMERS; TABLETS;

EID: 77954819631     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9409-9     Document Type: Article

References (47)

1. Ye Z, Rombout P, Remon JP, Vervaet C, Van den Mouter G. Correlation between the permeability Metoprolol tartrate through plasticized isolated Ethylcellulose/Hydroxypropyl Methylcellulose films and drug release from reservoir pellets. Eur J Pharm Biopharm. 2007;67:485-90.
2. Krishnaiah Y S R, Karthikayen RS, Satyanarayana V. A three-layer Guar Gum matrix tablet for oral controlled delivery of highly soluble Metoprolol tartrate. Int J Pharm. 2002;241(2):353-66. (Pubitemid 34718037)
3. Hong S, Oh SY. Dissolution kinetics and physical characterization of three-layered tablet with poly (ethylene oxide) core matrix capped by Carbopol. Int J Pharm. 2008;356:121-9.
4. Gennaro AR. Remington's Pharmaceutical Sciences. 18th ed. Eaton: Mack; 1990.
5. Eddington ND, Marroum P, Uppoor R, Hussain A. Development and internal validation of an in vitro-in vivo correlation for a hydrophilic Metoprolol tartrate extended-release tablet formulation. Pharm Res. 1998;15:466-73.
6. Cosijns A, Vervaet C, Luyten J, Mullens S, Siepmann F, Van Hoorebeke L. et al. Porous hydroxyapatite tablets as carriers for low-dosed drugs. Eur J Pharm Biopharm. 2007;67:498-506.
7. Verhoeven E, De Beer T R M, Van den Mooter G, Remon JP, Vervaet C. Influence of formulation and process parameters on the release characteristics of Ethylcellulose sustained-release mini-matrices produced by hot-melt extrusion. Eur J Pharm Biopharm. 2008;69:312-9.
8. Nakamura K, Nara E, Akiyama Y. Development of an oral sustained release drug delivery system utilizing pH-dependent swelling of Carboxyvinyl polymer. J Control Release. 2006;111:309-15.
9. Aqil M, Sultana Y, Ali A. Matrix type transdermal drug delivery systems of Metoprolol tartrate: in vitro characterization. Acta Pharm. 2003;53:119-25.
10. Narendra C, Srinath MS, Prakash Rao B. Development of three layered buccal compact containing Metoprolol tartrate by statistical optimization technique. Int J Pharm. 2005;304:102-14.
11. Ghosh LK, Sairam P, Gupta BK. Development and evaluation of an oral controlled release multiple emulsion drug delivery system of a specific beta blocker Metoprolol tartrate. Boll Chim Farm. 1996;135:468-71.
12. Ganga S, Ramarao R, Singh J. Effect of Azone on the iontophoretic transdermal delivery of Metoprolol tartrate through human epidermis in vitro. J Control Release. 1996;42:57-64.
13. Pillay V, Fassihi R. A novel approach for constant rate delivery of highly soluble bioactives from a simple monolithic system. J Control Release. 2000;67:67-78.
14. Özyazici M, Gökçe EH, Ertan G. Release and diffusional modeling of metronidazole lipid matrices. Eur J Pharm Biopharm. 2006;63:331-9.
15. Özgüney I, Ertan G, Güneri T. Dissolution characteristics of megaloporous tablets prepared with two kinds of matrix granules. Il Farmaco. 2004;59(7):549-55.
16. The United States Pharmacopeia. The National Formulary: USP XXIV, NF XIX. Rockville: The United States Pharmacopeia; 2000.
17. Martinez-Pacheco R, Vila-Vato JL, Sauto C, Pamos T. Controlled release of Cephalexin from double-layer tablets containing small proportions of Acrylic Resins. Int J Pharm. 1986;32:99-102.
18. Hardman JG, Limbird LE, Gilman AG. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill; 2001.
19. Jack D. Handbook of Clinical Pharmacokinetic Data. London: Macmillan; 1992.
20. Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 1987;5:37-42.
21. Al-Gohary O M N, Al-Kassas RS. Stability studies of Aspirinmagaldrate double layer tablets. Pharm Acta Helv. 2000;74:351-60.
22. Mathews BR. Regulatory aspects of stability testing in Europe. Drug Dev Ind Pharm. 1999;25:831-56.
23. Avdeef A, Berger CM. pH-metric solubility. Dissolution titration template method for solubility determination. Eur J Pharm Sci. 2001;14:281-91.
24. Meshali MM, Gabr KE. Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl. Int J Pharm. 1993;89(3):177-81.
25. Bonferoni MC, Rossi S, Ferrari F, Bertoni M, Bolhuis GK, Caramella C. On the employment of λ carrageenan in a matrix system. III. Optimization of a λ carrageenan-HPMC hydrophilic matrix. J Control Release. 1998;51:231-9.
26. Hejazi R, Amiji M. Chitosan-based gastrointestinal delivery systems. J Control Release. 2003;89:151-65.
27. Tapia C, Escobar Z, Costa E, Sapag-Hagar J, Valenzuela F, Basualto C et al. Comparative studies on polyelectrolyte complexes and mixtures of Chitosan-alginate and Chitosan-carrageenan as prolonged Diltiazem Clorhydrate release systems. Eur J Pharm Biopharm. 2004;57:65-75.
28. Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ. Design and evaluation of Chitosan/Ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release. 1998;55:143-52.
29. Miyazaki S, Kawasaki N, Nakamura T, Iwatsu M, Hayashi T, Hou WM et al. Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation. Int J Pharm. 2000;204:127-32.
30. Grabovac V, Föger F, Bernkop-Schnürch A. Design and in vivo evaluation of a patch delivery system for insulin based on thiolated polymers. Int J Pharm. 2008;348:169-74.
31. Colombo P, Bettini R, Santi P, Peppas NA. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Pharm Sci Technolo Today. 2000;3(6):198-204.
32. Baloǧlu E, Özyazici M, Hizarcioǧlu SY, Şenyiǧit T, Özyurt D, Pekçetin Ç. Bioadhesive controlled release systems of ornidazole for vaginal delivery. Pharm Dev Technol. 2006;11:477-84.
33. Guo J, Skinner GW, Harcum WW, Barnum PE. Pharmaceutical applications of naturally occurring water-soluble polymers. Pharm Sci Technolo Today. 1998;1:254-61.
34. Sriamornsak P, Thirawong N, Weerapol Y, Nunthanid J, Sungthongjeen S. Swelling and erosion of pectin matrix tablets and their impact on drug release behavior. Eur J Pharm Biopharm. 2007;67:211-9.
35. Sujja-areevath J, Munday DL, Cox J, Khan KA. Relationship between swelling, erosion and drug release in hydrophilic natural gum mini-matrix formulations. Eur J Pharm Sci. 1998;6:207-17.
36. Bonferoni MC, Rossi S, Tamajo M, Pedraz JL. Dominguez Gil A, Caramella C. On the employment of λ carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum. J Control Release. 1993;26:119-27.
37. Feely LC, Davis SS. The influence of polymeric excipients on drug release from hydroxypropylmethylcellulose matrices. Int J Pharm. 1988;44:131-9.
38. Rango Rao KV, Padmalatha Devi K, Buri P. Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymeric matrices. J Control Release. 1990;12:133-41.
39. Fassihi RA, Ritschel WA. Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation. J Pharm Sci. 1993;82:750-4.
40. Streubel A, Siepmann J, Peppas NA, Bodmeier R. Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design. J Control Release. 2000;69:455-68.
41. Lee PI, Peppas NA. Prediction of polymer dissolution in swellable controlled-release systems. J Control Release. 1987;6:207-15.
42. Kim H, Fassihi R. Application of a binary polymer system in drug release rate modulation. I. Characterisation of release mechanism. J Pharm Sci. 1996;86:316-22.
43. Kim H, Fassihi R. A new ternary polymeric matrix system for controlled drug delivery of highly soluble drugs. I. Diltiazem Hydrochloride. Pharm Res. 1997;14:1415-21.
44. Sangalli ME, Maroni A, Zema L, Cerea M, Conte U, Gazzaniga A. A study on the release mechanism of drugs from hydrophilic partially coated perforated matrices. Il Farmaco. 2003;58:971-6.
45. Picker KM. The use of carrageenan in mixture with micro-crystalline cellulose and its functionality for making tablets. Eur J Pharm Biopharm. 1999;48:27-36.
46. Bamba M, Puisieux JP, Marty JP, Carstensen JT. Physical model for release of drug from gel forming sustained release preparations. Int J Pharm. 1979;3:87-92.
47. Bamba M, Puisieux JP, Marty JP, Carstensen JT. Release mechanisms in gel forming sustained release preparations. Int J Pharm. 1979;2:307-15.