Correlation between the permeability of metoprolol tartrate through plasticized isolated ethylcellulose/hydroxypropyl methylcellulose films and drug release from reservoir pellets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 2, 2007, Pages 485-490

  Ye, Zhi wei ^a   Rombout, Patrick ^a   Remon, Jean Paul ^b   Vervaet, Chris ^b   Van den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Diffusion; Ethylcellulose; Hydroxypropyl methylcellulose; Metoprolol tartrate; Plasticizer; Release

Indexed keywords

ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; METOPROLOL TARTRATE; PHARMACOAT 615; PLASTICIZER; POLYMER; SOLVENT;

ARTICLE; CORRELATION ANALYSIS; DRUG COATING; DRUG DIFFUSION; DRUG DOSAGE FORM; DRUG PELLET; DRUG PENETRATION; DRUG RELEASE; FILM COATING; HYDROPHILICITY; PROCESS OPTIMIZATION;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIFFUSION; EQUIPMENT DESIGN; METHYLCELLULOSE; METOPROLOL; PERMEABILITY; PLASTICIZERS; POLYMERS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 34547687424     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.02.010     Document Type: Article

References (19)

1. Sousa J.J., Sousa A., Moura M.J., and Newton J.M. The influence of core materials and film coating on the drug release from coated pellets. Int. J. Pharm. 233 (2002) 111-122
2. Vaithiyalingam S., and Khan M.A. Optimization and characterization of controlled release multi-particulate beads formulated with a customized cellulose acetate butyrate dispersion. Int. J. Pharm. 234 (2002) 179-193
3. Rahman N., Yuen K.H., Khan N.A., and Wong J.W. Drug-polymer mixed coating: a new approach for controlling drug release rates in pellets. Pharm. Dev. Technol. 11 (2006) 71-77
4. McGinity J.W. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. second ed. (1997), Marcel Dekker, New York
5. G. Cole, J. Hogan, A. Michael, Mechanical properties of film coats: tests for the assessment of film mechanical properties, in: Pharmaceutical Coating Technology, Taylor & Francis, London, 1995.
6. Porter S.C. The effect of additives on the properties of an aqueous film coating. Pharm. Technnol. 4 (1980) 67-75
7. Rekhi G.S., and Jambhekar S.S. Ethylcellulose-a polymer review. Drug Dev. Ind. Pharm. 21 (1995) 61-77
8. Aulton M.E., Abdul-Razzak M.H., and Hogan J.E. The mechanical properties of hydroxypropylmethylcellulose films derived from aqueous systems. Part 1: the influence of plasticizers. Drug Dev. Ind. Pharm. 7 (1981) 649-668
9. F.W. Billmeyer, Polymer processing, plastic technology, in: Textbook of Polymer Science, third ed., Wiley-Interscience, New York, 1984.
10. Kibbe A.H. Handbook of Pharmaceutical Excipients. third ed. (2003), American Pharmaceutical Association and Pharmaceutical Press, Washington DC
11. Guo J.H. An investigation into the formation of plasticizer channels in plasticized polymer films. Drug Dev. Ind. Pharm. 20 (1994) 1883-1893
12. Hamed E., and Sakr A. Effect of curing conditions and plasticizer level on the release of highly lipophilic drug from coated multiparticulate drug delivery system. Pharm. Dev. Technol. 8 (2003) 397-407
13. Van den Mooter G., Samyn C., and Kinget R. Characterization of colon-specific azo polymers: a study of the swelling properties and the permeability of isolated polymer films. Int. J. Pharm. 111 (1994) 127-136
14. A.T. Florence, Plasticizers used in film coating, in: Materials Used in Pharmaceutical Formulation, Belgrave Square, London, 1984.
15. Frohoff-Hülsmann M.A., Lippold B.C., and McGinity J.W. Aqueous ethyl cellulose dispersion containing plasticizers of different water solubility and hydroxypropyl methyl-cellulose as coating material for diffusion pellets II: properties of sprayed films. Eur. J. Pharm. Biopharm. 48 (1999) 67-75
16. Lecomte F., Siepmann J., and Walther M. Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer. J. Control. Release 99 (2004) 1-13
17. Fan L.T., and Singh S.K. Controlled Release: A Quantitative Treatment (1989), Springer-Verlag, Berlin
18. Hjartstam J., and Hjertberg T. Swelling of pellets coated with a composite film containing ethyl cellulose and hydroxypropyl methylcellulose. Int. J. Pharm. 161 (1998) 23-28
19. Sun Y.M., Chang C.C., Huang W.F., and Liang H.C. Fluidized-bed spray coated porous hydrogel beads for sustained release of diclofenac sodium. J. Control. Release 47 (1997) 247-260