Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 1, 2004, Pages 65-75

  Tapia, Cristián ^a   Escobar, Zunilda ^a   Costa, Edda ^a   Sapag Hagar, Jaime ^a   Valenzuela, Fernando ^a   Basualto, Carlos ^a   Gai, María Nella ^a   Yazdani Pedram, Mehrdad ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Alginate; Carrageenan; Chitosan; Matrices; Polyelectrolyte complex; Prolonged drug release

Indexed keywords

ALGINIC ACID; CARRAGEENAN; CHITOSAN; CHLORIDE; DILTIAZEM; POLYELECTROLYTE; POLYMER; SOLVENT;

ARTICLE; COMPLEX FORMATION; CONTROLLED DRUG RELEASE; DIFFUSION; DRUG FORMULATION; DRUG MECHANISM; DRUG PENETRATION; DRUG SOLUBILITY; EVALUATION; MODEL; TABLET FORMULATION;

EID: 0346724867     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(03)00153-X     Document Type: Article

References (13)

1. Tapia C., Costa E., Moris M., Sapag-Hagar J., Valenzuela F., Basualto C. Study of the influence of the pH media dissolution, degree of polymerization, and degree of swelling of the polymers on the mechanism of release of Diltiazem from matrices based on mixtures chitosan-alginate. Drug Dev. Ind. Pharm. 28:2002;217-224.
2. Gupta V., Hariharan M., Wheatley T., Price J. Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors. Eur. J. Pharm. Biopharm. 51:2001;241-248.
3. Sakayama T., Chu C., Fujii T., Yano T. Preparation of a polyelectrolyte complex gel from chitosan and κ-carrageenan and its pH-sensitive swelling. J. Appl. Polym. Sci. 50:1993;2021-2025.
4. Rinaudo M., Milas M., Le Dung P. Characterization of chitosan. Influence of ionic strength and degree of acetylation on chain expansion. Int. J. Biol. Macromol. 15:(5):1993;281-285.
5. Takayama K., Hirata M., Machida Y., Masada T., Sannan T., Nagai T. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate. Chem. Pharm. Bull. (7):1990;1993-1997.
6. The United States Pharmacopeia XXIV, 24th Rev., United States Pharmacopeial Convention, Rockville 2000.
7. Berens A., Hopfenberg H. Diffusion and relaxation in glassy polymer powders: 2. Separation of diffusion and relaxation parameters. Polymer. 19:1978;489-496.
8. Vachoud L., Zydowicz N., Domard A. Physicochemical behavior of chitin gels. Carbohydr. Res. 326:2000;295-304.
9. Roberts M., Zhong H., Prodolliet J., Goodall D. Separation of high-molecular-mass carrageenan polysaccharides by capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. A. 817:1998;353-366.
10. Caram-Lelham N., Sundelöf L. The effect of hydrophobic character of drugs and helix-coil transition of κ-carrageenan on the polyelectrolyte-drug interaction. Pharm. Res. 13:1996;920-925.
11. Picker K. The use of carrageenan in mixture with microcrystalline cellulose and its functionality for making tablets. Eur. J. Pharm. Biopharm. 48:1999;27-36.
12. 2. Pharm. Res. 15:1998;889-896.
13. Caramella C., Ferrari F., Bonferoni M., Sangalli M., Bernardi M., Feletti F., Galmozzi M. In vitro/in vivo correlation of prolonged release dosage form containing diltiazem HCl. Biopharm. Drugs Dispos. 14:1993;143-160.