Development of an oral sustained release drug delivery system utilizing pH-dependent swelling of carboxyvinyl polymer

Journal of Controlled Release

Volumn 111, Issue 3, 2006, Pages 309-315

  Nakamura, Kenji ^a   Nara, Eiji ^a   Akiyama, Yohko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Carboxyvinyl polymer; Oral delivery system; Release regulating layer; Sustained release; Swelling

Indexed keywords

COATINGS; PH EFFECTS; POLYMERS; SWELLING;

CARBOXYVINYL POLYMERS; ORAL DELIVERY SYSTEM; RELEASE-REGULATING LAYERS; SUSTAINED-RELEASE;

CONTROLLED DRUG DELIVERY;

CARBOMER; METOPROLOL TARTRATE; MORPHINE;

ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG COATING; DRUG DELIVERY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PH MEASUREMENT; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ANALGESICS, OPIOID; ANIMALS; DELAYED-ACTION PREPARATIONS; DOGS; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; METOPROLOL; MORPHINE; SOLUBILITY;

EID: 33645241768     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.12.018     Document Type: Article

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