Investigation of the physicochemical and physicomechanical properties of a novel intravaginal bioadhesive polymeric device in the pig model

AAPS PharmSciTech

Volumn 11, Issue 2, 2010, Pages 793-808

  Ndesendo, Valence M K ^a   Pillay, Viness ^a   Choonara, Yahya E ^a   Du Toit, Lisa C ^a   Buchmann, Eckhart ^b   Meyer, Leith C R ^a   Khan, Riaz A ^c   Rosin, Uwe ^d  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c INTEGRAL UNIVERSITY   (India)

^d Research and Development Unit   (South Africa)

Author keywords

Bioadhesivity; Controlled release; Intravaginal drug delivery; Microbicidal polymeric device; Physicochemical and physicomechanical characterization

Indexed keywords

ADHESIVE AGENT; BARIUM SULFATE; ETHYL CELLULOSE; PENTAERYTHRITOL; POLYACRYLIC ACID; POLYMER; POLYSTYRENESULFONIC ACID; POLYVINYL ALCOHOL; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DELAYED RELEASE FORMULATION; TISSUE ADHESIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; FEMALE; IN VITRO STUDY; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RADIOGRAPHY; STEADY STATE; SWINE; TABLET COMPRESSION; THERMAL ANALYSIS; TISSUE ADHESION; VAGINA; VAGINA DISCHARGE; ADHESION; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG FORMULATION; PROCEDURES; SURFACE PROPERTY; SYNTHESIS; TENSILE STRENGTH;

ADHESIVENESS; ANIMALS; ANTI-HIV AGENTS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG COMPOUNDING; FEMALE; SURFACE PROPERTIES; SWINE; TENSILE STRENGTH; TISSUE ADHESIVES; VAGINA; ZIDOVUDINE;

EID: 77954817534     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9439-3     Document Type: Article

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