K65R and K65A Substitutions in HIV-1 Reverse Transcriptase Enhance Polymerase Fidelity by Decreasing Both dNTP Misinsertion and Mispaired Primer Extension Efficiencies

Journal of Molecular Biology

Volumn 401, Issue 1, 2010, Pages 33-44

  Garforth, Scott J ^a   Domaoal, Robert A ^b   Lwatula, Chisanga ^a   Landau, Mark J ^b   Meyer, Amanda J ^b   Anderson, Karen S ^b   Prasad, Vinayaka R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HIV 1 reverse transcriptase; NRTI resistance mutation; Polymerase fidelity; Pre steady state kinetics of HIV 1 RT; Site specific footprinting

Indexed keywords

AMINO ACID; HYDROXYL RADICAL; NUCLEOTIDE; PARATHION; RNA DIRECTED DNA POLYMERASE;

ARTICLE; BASE MISPAIRING; DNA FOOTPRINTING; GENE INSERTION; GENE MUTATION; PRIORITY JOURNAL; VIRUS MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77954761712     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.06.001     Document Type: Article

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