Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase

Journal of Biological Chemistry

Volumn 274, Issue 46, 1999, Pages 32924-32930

  Lewis, Deborah A ^a   Bebenek, Katarzyna ^a   Beard, William A ^a   Wilson, Samuel H ^a   Kunkel, Thomas A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE BINDING PROTEIN; RNA DIRECTED DNA POLYMERASE;

AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; BINDING AFFINITY; COMPLEX FORMATION; DNA REPLICATION; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; FRAMESHIFT MUTATION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY;

BASE PAIRING; BASE SEQUENCE; BINDING SITES; DEOXYRIBONUCLEOTIDES; DNA PRIMERS; DNA REPLICATION; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC;

EID: 0032731354     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.46.32924     Document Type: Article

References (54)

1. Loeb, L. A., and Kunkel, T. A. (1982) Annu. Rev. Biochem. 51, 429-457
2. Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., and Kraut, J. (1994) Science 264, 1891-1903
3. Pelletier, H., Sawaya, M. R., Wolfle, W., Wilson, S. H., and Kraut, J. (1996) Biochemistry 35, 12742-12761
4. Doublié, S., Tabor, S., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998) Nature 391, 251-258
5. Kiefer, J. R., Mao, C., Braman, J. C., and Beese, L. S. (1998) Nature 391, 304-307
6. Huang, H., Chopra, R., Verdine, G. L., and Harrison, S. C. (1998) Science 282, 1669-1675
7. Li, Y., Korolev, S., and Waksman, G. (1998) EMBO J. 17, 7514-7525
8. Kunkel, T. A., and Wilson, S. H. (1998) Nat. Struct. Biol. 5, 95-99
9. Echols, H., and Goodman, M. F. (1991) Annu. Rev. Biochem. 60, 477-511
10. Petruska, J., Sowers, L. C., and Goodman, M. F. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 1559-1562
11. Kool, E. T. (1998) Biopolymers 48, 3-17
12. Roberts, J. D., Bebenek, K., and Kunkel, T. A. (1988) Science 242, 1171-1173
13. Perrino, F. W., Preston, B. D., Sandell, L. L., and Loeb, L. A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 8343-8347
14. Yu, H., and Goodman, M. F. (1992) J. Biol. Chem. 267, 10888-10896
15. Temin, H. M. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6900-6903
16. Patel, P. H., and Preston, B. D. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 549-553
17. Bebenek, K., Abbotts, J., Roberts, J. D., Wilson, S. H., and Kunkel, T. A. (1989) J. Biol. Chem. 264, 16948-16956
18. Bebenek, K., Abbotts, J., Wilson, S. H., and Kunkel, T. A. (1993) J. Biol. Chem. 268, 10324-10334
19. Bebenek, K., and Kunkel, T. A. (1995) Methods Enzymol. 262, 217-232
20. Bebenek, K., Beard, W. A., Darden, T. A., Li, L., Prasad, R., Luxon, B. A., Gorenstein, D. G., Wilson, S. H., and Kunkel, T. A. (1997) Nat. Struct. Biol. 3, 194-197
21. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6320-6324
22. Kim, B., Hathaway, T. R., and Loeb, L. A. (1996) J. Biol. Chem. 271, 4872-4878
23. Xiong, Y., and Eickbush, T. H. (1990) EMBO J. 9, 3353-3362
24. Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., and Cech, T. R. (1997) Science 276, 561-567
25. Sarafianos, S. G., Pandey, V. N., Kaushik, N., and Modak, M. J. (1995) J. Biol. Chem. 270, 19729-19735
26. Kunkel, T. A., Bebenek, K., and McClary, J. (1991) Methods Enzymol. 204, 125-139
27. Goel, R., Beard, W. A., Kumar, A., Casas-Finet, J. R., Strub, M. P., Stahl, S. J., Lewis, M. S., Bebenek, K., Becerra, S. P., Kunkel, T. A., and Wilson, S. H. (1993) Biochemistry 32, 13012-13018
28. Becerra, S. P., Kumar, A., and Wilson, S. H. (1993) Protein Exp. Purif. 4, 187-199
29. Beard, W. A., Stahl, S. J., Kim, H.-R., Bebenek, K., Kumar, A., Strub, M.-P., Becerra, S. P., Kunkel, T. A., and Wilson, S. H. (1994) J. Biol. Chem. 269, 28091-28097
30. Kroutil, L. C., Register, K., Bebenek, K., and Kunkel, T. A. (1996) Biochemistry 35, 1046-1053
31. Kati, W. M., Johnson, K. A., Jerva, L. F., and Anderson, K. S. (1992) J. Biol. Chem. 287, 25988-25997
32. Boosalis, M. S., Petruska, J., and Goodman, M. F. (1987) J. Biol. Chem. 262, 14689-14696
33. Mendelman, L. V., Petruska, J., and Goodman, M. F. (1990) J. Biol. Chem. 265, 2338-2346
34. Creighton, S., Huang, M.-M., Cai, H., Arnheim, N., and Goodman, M. F. (1992) J. Biol. Chem. 267, 2633-2639
35. Bebenek, K., Joyce, C. M., Fitzgerald, M. P., and Kunkel, T. A (1990) J. Biol. Chem. 265, 13878-13887
36. Boyer, J. C., Bebenek, K., and Kunkel, T. A. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6919-6923
37. Beard, W. A., Osheroff, W. P., Prasad, R., Sawaya, M. R., Jaju, M., Wood, T. G., Kraut, J., Kunkel, T. A., and Wilson, S. H. (1996) J. Biol. Chem. 271, 12141-12144
38. Ahn, J., Werneburg, B. G., and Tsai, M. D. (1997) Biochemistry 36, 1100-1107
39. Osheroff, W. P., Beard, W. A., Wilson, S. H., and Kunkel, T. A. (1999) J. Biol. Chem. 274, 20749-20752
40. Carroll, S. S., Cowart, M., and Benkovic, S. J. (1991) Biochemistry 30, 804-813
41. Bell, J. B., Eckert, K. A., Joyce, C. M., and Kunkel, T. A. (1997) J. Biol. Chem. 272, 7345-7351
42. Minnick, D. T., Bebenek, K., Osheroff, W. P., Turner, R. M., Jr., Astatke, M., Liu, L., Kunkel, T. A., and Joyce, C. M. (1999) J. Biol. Chem. 274, 3067-3075
43. Wainberg, M. A., Drosopoulos, W. C., Salomon, H., Hsu, M., Borkow, G., Parniak, M. A., Gu, Z. X., Song, Q. B., Manne, J., Islam, S., Castriota, G., and Prasad, V. R. (1996) Science 271, 1282-1285
44. Pandey, V. N., Kaushik, N., Rege, N., Sarafianos, S. G., Yadav, P. N. S., and Modak, M. J. (1996) Biochemistry 35, 2168-2179
45. Bakhanashvili, M., Avidan, O., and Hizi, A. (1996) FEBS Lett. 391, 257-262
46. Martín-Hernández, A. M., Domingo, E., and Menéndez-Arias, L. (1996) EMBO J. 15, 4434-4442
47. Martín-Hernández, A. M., Gutierrez-Rivas, M., Domingo, E., and Menéndez-Arias, L. (1997) Nucleic Acids Res. 25, 1383-1389
48. Lipanov, A., Kopka, M. L., Kaczor-Grzeskowiak, M., Quintana, J., and Dickerson, R. E. (1993) Biochemistry 32, 1373-1389
49. Crothers, D. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15163-15165
50. Dornberger, U., Flemming, J., and Fritzsche, H. (1998) J. Mol. Biol. 284, 1453-1463
51. Olson, W. K., Gorin, A. A., Lu, X. J., Hock, L. M., and Zhurkin, V. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11163-11168
52. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950
53. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
54. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296