Dietary flavonoids suppress adipogenesis in 3T3-L1 preadipocytes

Journal of Food and Drug Analysis

Volumn 13, Issue 2, 2005, Pages

  Chien, Po Jung ^a   Chen, Ying Chen ^b   Lu, Shou Chin ^c   Sheu, Fuu ^b  

^a YUANPEI UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

3T3 L1 adipocyte; Adipogenic differentiation; Dietary flavonoids

Indexed keywords

CATECHIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; FLAVONOID; KAEMPFEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; QUERCETIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

ADIPOSE TISSUE CELL; ANIMAL CELL; ARTICLE; BODY WEIGHT; CELL CULTURE; CELL DIFFERENTIATION; CELL STRAIN 3T3; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DIET SUPPLEMENTATION; DIETARY INTAKE; FATTY ACID SYNTHESIS; GROWTH INHIBITION; LIPOGENESIS; MITOSIS INHIBITION; MOUSE; NONHUMAN; PROADIPOCYTE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

ANIMALIA;

EID: 23944437502     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Middleton, E. Jr. and Kandaswami, C. 1993. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In "The Flavonoids Advances in Research since 1986". pp. 619-652. Harborme, J. B. ed. Chapman and Hall. London, U. K.
2. Cook, N. C. and Samman, S. 1996. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary resources. J. Nutr. Biochem. 7: 66-76.
3. Havsteen, B. H. 2002. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 96: 67-202.
4. Kuppusamy, U. R. and Das, N. P. 1992. Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. Biochem. Pharmacol. 44: 1307-1315.
5. Kuppusamy, U. R. and Das, N. P. 1994. Potentiation of beta-adrenoceptor agonist-mediated lipolysis by quercetin and fisetin in isolated rat adipocytes. Biochem. Pharmacol. 47: 521-519.
6. Shisheva, A. and Shechter, Y. 1992. Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes. Biochemistry 31: 8059-8063.
7. Harmon, A. W. and Harp, J. B. 2001. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am. J. Physiol. Cell Physiol. 280: C807-C813.
8. Harmon, A. W., Patel, Y. M. and Harp, J. B. 2002. Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPβ) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression. Biochem. J. 367: 203-208.
9. Harmon, A. W. and Patel, Y. M. 2003. Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 305: 229-234.
10. Spiegelman, B. M., Hu, E., Kim, J. B. and Brun, R. 1997. PPAR gamma and the control of adipogenesis. Biochimie 79: 111-112.
11. Lane, M. D., Lin, F. T., MacDougald, O. A. and Vasseur-Cognet, M. 1996. Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int. J. Obes. Relat. Metab. Disord. 20: 91-96.
12. Brown, M. S. and Goldstein, J. L. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340.
13. Pai, J. T., Guryev, O., Brown, M. S. and Goldstein, J. L. 1998. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J. Biol. Chem. 273: 26138-26148.
14. Rubin, C. S., Hirsch, A., Fung, C. and Rosen, O. M. 1978. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J. Biol. Chem. 253: 7570-7578.
15. Hasegawa, N. 2000. Inhibition of lipogenesis by pycnogenol. Phytother. Res. 14: 472-473.
16. Dell'Agli, M. and Bosisio, E. 2002. Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes. Planta Medica 68: 76-79.
17. Packer, L., Rimbach, G. and Virgili, F. 1999. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic. Biol. Med. 27: 704-724.
18. van Beek, T. A. 2002. Chemical analysis of Ginkgo biloba leaves and extracts. J. Chromatogr. A 967: 21-55.
19. Ignotz, R. A. and Massague, J. 1985. Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 82: 8530-8534.
20. Scott, R. E., Florine, D. L., Wille, J. J. Jr. and Yun, K. 1982. Coupling of growth arrest and differentiation at a distinct state in the G1 phase of the cell cycle: GD. Proc. Natl. Acad. Sci. U. S. A. 79: 845-849.
21. Soukas, A., Socci, N. D., Saatkamp, B. D., Novelli, S. and Friedman, J. M. 2001. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276: 34167-34174.
22. Harp, J. B. 2004. New insights into inhibitors of adipogenesis. Curr. Opin. Lipidol. 15: 303-307.
23. Mandrup, S. and Lane, M. D. 1997. Regulating adipogenesis. J. Biol. Chem. 272: 5367-5370.
24. Rosen, E. D., Hsu, C. H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J. and Spiegelman, B. M. 2002. C/EBP-alpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 16: 22-26.
25. Yeh, W. C., Cao, Z., Classon, M. and McKnight, S. L. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9: 168-181.
26. Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L. and MacDougald, O. A. 2000. Inhibition of adipogenesis by Wnt signaling. Science 289: 950-953.
27. Moldes, M., Zuo, Y., Morrison, R. F., Silva, D., Park, B. H., Liu, J. and Farmer, S. R. 2003. Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem. J. 376: 607-613.
28. Hagiwara, M., Inoue, S., Tanaka, T., Nunoki, K., Ito, M. and Hidaka, H. 1988. Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem. Pharmacol. 37: 2987-2892.
29. Strobel, P., Allard, C., Perez-Acle, T., Calderon, R., Aldunate, R. and Leighton, F. 2005. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem. J. (In press)
30. Furuyashiki, T., Nagayasu, H., Aoki, Y., Bessho, H., Hashimoto, T., Kanazawa, K. and Ashida, H. 2004. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPAR-gamma 2 and C/EBP-alpha in 3T3-L1 cells. Biosci. Biotechnol. Biochem. 68: 2353-2359.
31. Ardevol, A., Blade, C., Salvado, M. J. and Arola, L. 2000. Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes. Int. J. Obes. Relat. Metab. Disord. 24: 319-324.
32. Mochizuki, M. and Hasegawa, N. 2004. Effects of green tea catechin-induced lipolysis on cytosol glycerol content in differentiated 3T3-L1 cells. Phytother Res. 18: 945-946.
33. Sayama, K., Lin, S., Zheng, G. and Oguni, I. 2000. Effects of green tea on growth, food utilization and lipid metabolism in mice. In Vivo 14: 481-484.
34. Kao, Y. H., Hiipakka, R. A. and Liao, S. 2000. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141: 980-987.
35. Murase, T., Nagasawa, A., Suzuki, J., Hase, T. and Tokimitsu, I. 2002. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int. J. Obes. Relat. Metab. Disord. 26: 1459-1464.
36. Dulloo, A. G., Duret, C., Rohrer, D., Girardier, L., Mensi, N., Fathi, M., Chantre, P. and Vandermander, J. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clin. Nutr. 70: 1040-1045.
37. Crespy, V. and Williamson, G. 2004. A review of the health effects of green tea catechins in in vivo animal models. J. Nutr. 134: 3431S-3440S.
38. Moreno, D. A., Ilic, N., Poulev, A., Brasaemle, D. L., Fried, S. K. and Raskin, I. 2003. Inhibitory effects of grape seed extract on lipases. Nutrition 19: 876-879.
39. Mori, M. and Hasegawa, N. 2003. Superoxide dismutase activity enhanced by green tea inhibits lipid accumulation in 3T3-L1 cells. Phytother. Res. 17: 566-567.