Inhibitory influence of mecamylamine on the development and the expression of ethanol-induced locomotor sensitization in mice

Pharmacology Biochemistry and Behavior

Volumn 96, Issue 3, 2010, Pages 266-273

  Bhutada, Pravinkumar S ^a   Mundhada, Yogita R ^a   Bansod, Kuldeep U ^a   Dixit, Pankaj V ^b   Umathe, Sudhir N ^c   Mundhada, Dharmendra R ^a  

^a Agnihotri College of Pharmacy Wardha   (India)

^b IPS Academy   (India)

^c RTM NAGPUR UNIVERSITY   (India)

Author keywords

Addiction; Ethanol; Mecamylamine; Mice; Neuronal nicotinic acetylcholine receptor; Psychomotor sensitization

Indexed keywords

ALCOHOL; MECAMYLAMINE; CENTRAL DEPRESSANT AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; SENSITIZATION; ANIMAL; BLOOD; BODY EQUILIBRIUM; DRUG EFFECTS; MOTOR ACTIVITY; PSYCHOMOTOR PERFORMANCE; STIMULATION;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MALE; MECAMYLAMINE; MICE; MOTOR ACTIVITY; NICOTINIC ANTAGONISTS; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; RECEPTORS, NICOTINIC; STIMULATION, CHEMICAL;

MUS;

EID: 77954760108     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.05.015     Document Type: Article

References (78)

1. Bellot R.G., Camarini R., Vital M.A., Palermo-Neto J., Leyton V., Frussa-Filho R. Monosialoganglioside attenuates the excitatory and behavioural sensitization effects of ethanol. Eur J Pharmacol 1996, 313:175-179.
2. Bhutada P., Mundhada Y., Bansod K., Dixit P., Umathe S., Mundhada D. Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav 2010, 10.1016/j.yebeh.2010.03.007.
3. Bhutada P.S., Mundhada Y.R., Bansod K.U., Umathe S.N., Kahale V.P., Dixit P.V., et al. Inhibitory influence of mecamylamine on ethanol withdrawal-induced symptoms in C57BL/6J mice. Behav Pharmacol 2010, 21:90-95.
4. Biggio G., Concas A., Follesa P., Sanna E., Serra M. Stress, ethanol, and neuroactive steroids. Pharmacol Ther 2007, 116:140-171.
5. Blomqvist O., Engel J.A., Nissbrandt H., Soderpalm B. The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine. Eur J Pharmacol 1993, 249:207-213.
6. Blomqvist O., Ericson M., Engel J.A., Soderpalm B. Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. Eur J Pharmacol 1997, 334:149-156.
7. Blomqvist O., Hernandez-Avila C.A., Van Kirk J., Rose J.E., Kranzler H.R. Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. Alcohol Clin Exp Res 2002, 26:326-331.
8. Bobo J.K., Gilchrist L.D., Schilling R.F., Noach B., Schinke S.P. Cigarette smoking cessation attempts by recovering alcoholics. Addict Behav 1987, 12:209-215.
9. Boerngen-Lacerda R., Souza-Formigoni M.L.O. Does the increase in locomotion induced by ethanol indicate its stimulant or anxiolytic properties?. Pharmacol Biochem Behav 2000, 67:225-232.
10. Boyce-Rustay J.M., Wiedholz L.M., Millstein R.A., Carroll J., Murphy D.L., Daws L.C., et al. Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol Clin Exp Res 2006, 30:1957-1965.
11. Broadbent J., Harless W.E. Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2J mice. Psychopharmacology (Berl) 1999, 141:197-205.
12. Broadbent J., Kampmueller K.M., Koonse S.A. Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors. Psychopharmacology (Berl) 2003, 167:225-234.
13. Broadbent J., Kampmueller K.M., Koonse S.A. Role of dopamine in behavioral sensitization to ethanol in DBA/2J mice. Alcohol 2005, 35:137-148.
14. Cador M., Bjijou Y., Stinus L. Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine. Neuroscience 1995, 65:385-395.
15. Camarini R., Andreatini R., Monteiro M.G. Prolonged treatment with carbamazepine increases the stimulatory effects of ethanol in mice. Alcohol 1995, 12:305-308.
16. Champtiaux N., Kalivas P.W., Bardo M.T. Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats. Behav Brain Res 2006, 168:120-126.
17. Chi H., de Wit H. Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers. Alcohol Clin Exp Res 2003, 27:780-786.
18. Clarke P.B., Pert C.B., Pert A. Autoradiographic distribution of nicotine receptors in rat brain. Brain Res 1984, 323:390-395.
19. de Araujo N.P., Fukushiro D.F., Grassl C., Hipólide D.C., Souza-Formigoni M.L., Tufik S., et al. Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle. Physiol Behav 2009, 96:12-17.
20. De Vries T.J., Schoffelmeer A.N., Binnekade R., Mulder A.H., Vanderschuren L.J. Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur J Neurosci 1998, 10:3565-3571.
21. Ericson M., Molander A., Lof E., Engel J.A., Soderpalm B. Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. Eur J Pharmacol 2003, 467:85-93.
22. Faingold C.L., N'Gouemo P., Riaz A. Ethanol and neurotransmitter interactions from molecular to integrative effects. Prog Neurobiol 1998, 55:509-535.
23. Fee J.R., Sparta D.R., Picker M.J., Thiele T.E. Corticotropin releasing factor (CRF)-1 receptor antagonist, CP-154, 526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice. Neuroscience 2007, 150:14-21.
24. Ferraz I.C., Boerngen-Lacerda R. Serotonin 5-HT2 receptor antagonist does not reverse established ethanol-induced sensitization but blocks its development and expression. Pharmacol Biochem Behav 2008, 88:456-464.
25. Fish E.W., DeBold J.F., Miczek K.A. Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice. Psychopharmacology (Berl) 2002, 160:39-48.
26. Ford M.M., Fretwell A.M., Nickel J.D., Mark G.P., Strong M.N., Yoneyama N., et al. The influence of mecamylamine on ethanol and sucrose self-administration. Neuropharmacology 2009, 57:250-258.
27. Forman S.A., Zhou Q. Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol. Alcohol Clin Exp Res 2000, 24:1363-1368.
28. Fu H., Dou J., Li W., Luo J., Li K.C., Lam C.S., et al. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic independent mechanisms. Neuropharmacology 2008, 54:755-765.
29. Funk D., Marinelli P.W., Le A.D. Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors. Alcohol Res Health 2006, 29:186-192.
30. Goeldner F.O., Pigatto G., Ribeiro A.F., Machado H.B., Boerngen-Lacerda R. Influence of fluoxetine and paroxetine in behavioral sensitization induced by ethanol in mice. Pharmacol Biochem Behav 2005, 82:388-396.
31. Grant B.F., Hasin D.S., Chou S.P., Stinson F.S., Dawson D.A. Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 2004, 61:1107-1115.
32. Hendrickson L.M., Zhao-Shea R., Tapper A.R. Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice. Psychopharmacology 2009, 204:563-572.
33. Henry D.J., White F.J. The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons. J Neurosci 1995, 15:6287-6299.
34. Hunt W.A., Lands W.E. A role for behavioral sensitization in uncontrolled ethanol intake. Alcohol 1992, 9:327-328.
35. Itzhak Y., Martin J.L. Blockade of alcohol-induced locomotor sensitization and conditioned place preference in DBA mice by 7-nitroindazole. Brain Res 2000, 858:402-407.
36. Kalivas P.W., Duffy P. Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse 1990, 5:48-58.
37. Kalivas P.W., Stewart J. Dopamine transmission in the initiation and expression of drug-and stress-induced sensitization of motor activity. Brain Res Brain Res Rev 1991, 16:223-244.
38. Kamens H.M., Phillips T.J. A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine-or methamphetamine-induced stimulation. Psychopharmacology 2008, 196:377-387.
39. Karler R., Calder L.D., Bedingfield J.B. A novel nicotinic cholinergic role in behavioral sensitization to amphetamine induced stereotypy in mice. Brain Res 1996, 725:192-198.
40. Kempsill F.E.G., Pratt J.A. Mecamylamine but not the a7 receptor antagonist a-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine. Br J Pharmacol 2000, 131:997-1003.
41. Klink R., de Kerchove d'Exaerde A., Zoli M., Changeux J.P. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001, 21:1452-1463.
42. Koob G.F. Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. PNAS 2008, 105:8809-8810.
43. Kotlinska J., Bochenski M., Danysz W. N-methyl-d-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice. Behav Pharmacol 2006, 17:1-8.
44. Kotlinska J., Pachuta A., Dylag T., Silberring J. The role of neuropeptide FF (NPFF) in the expression of sensitization to hyperlocomotor effect of morphine and ethanol. Neuropeptides 2007, 41:51-58.
45. Larsson A., Engel J.A. Neurochemical and behavioral studies on ethanol and nicotine interactions. Neurosci Biobehav Rev 2004, 27:713-720.
46. Larsson A., Jerlhag E., Svensson L., Soderpalm B., Engel J.A. Is an alpha-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of ethanol?. Alcohol 2004, 4:239-250.
47. Larsson A., Svensson L., Söderpalm B., Engel J.A. Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice. Alcohol 2002, 28:157-167.
48. Le A.D., Corrigall W.A., Harding J.W., Juzytsch W., Li T.K. Involvement of nicotinic receptors in alcohol self-administration. Alcohol Clin Exp Res 2000, 24:155-163.
49. Lessov C.N., Phillips T.J. Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology (Berl) 1998, 135:374-382.
50. Lister R.G. The effects of repeated doses of ethanol on exploration and its habituation. Psychopharmacology (Berl) 1987, 92:78-83.
51. Little H.J. Behavioral mechanisms underlying the link between smoking and drinking. Alcohol Res Health 2000, 24:215-224.
52. Masur J., Boerngen R. The excitatory component of ethanol in mice: a chronic study. Pharmacol Biochem Behav 1980, 13:777-780.
53. McDonough J.H., Shih T. A study of the IV-methyl-d-aspartate antagonistic properties of anticholinergic drugs. Pharmacol Biochem Behav 1995, 51:249-253.
54. Miller D.K., Segert I.L. Mecamylamine attenuates ephedrine induced hyperactivity in rats. Pharmacol Biochem Behav 2005, 81:165-169.
55. Nadal R., Chappell A.M., Samson H.H. Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self administration. Alcohol Clin Exp Res 1998, 22:1190-1198.
56. Narahashi T., Aistrup G.L., Marszalec W., Nagata K. Neuronal nicotinic acetylcholine receptors: a new target site of ethanol. Neurochem Int 1999, 35:131-141.
57. Nestler E.J., Aghajanian G.K. Molecular and cellular basis of addiction. Science 1997, 278:58-63.
58. O'Dell T.J., Christensen B.N. Mecamylamine is a selective noncompetitive antagonist of N-methyl-d-aspartate- and aspartate induced currents in horizontal cells dissociated from the catfish retina. Neurosci Lett 1988, 94:93-98.
59. Palmer A.A., Low M.J., Grandy D.K., Phillips T.J. Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behav Genet 2003, 33:311-324.
60. Phillips T.J., Huson M., Gwiazdon C., Burkhart-Kasch S., Shen E.H. Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol Clin Exp Res 1995, 19:269-278.
61. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 1993, 18:247-291.
62. Robinson T.E., Kolb B. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 2004, 7:33-46.
63. Rustay N.R., Wahlsten D., Crabbe J.C. Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behav Brain Res 2003, 141:237-249.
64. Schoffelmeer A.N., De Vries T.J., Wardeh G., Van de Ven H.W., Vanderschuren L.J. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. J Neurosci 2002, 22:3269-3276.
65. Segal D.S., Schuckit M.A. Animal models of stimulant induced psychosis. Stimulants: neurochemical, behavioral, and clinical perspectives 1983, 131-167. Raven Press, New York. I. Creese (Ed.).
66. Soderpalm B., Ericson M., Olausson P., Blomqvist O., Engel J.A. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behav Brain Res 2000, 113:85-96.
67. Umathe S.N., Bhutada P.S., Dixit P.V., Jain N.S. Leuprolide-a luteinizing hormone-releasing hormone agonist attenuates ethanol-withdrawal syndrome and ethanol-induced locomotor sensitization in mice. Neuropeptides 2008, 42:345-353.
68. Umathe S.N., Bhutada P.S., Raut V.S., Jain N.S., Mundhada Y.R. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol 2009, 20:78-83.
69. Vanderschuren L.J., Kalivas P.W. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 2000, 151:99-120.
70. Walton R.G. Smoking and alcoholism: a brief report. Am J Psychiatry 1972, 128:1455-1456.
71. White F.J., Kalivas P.W. Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 1998, 51:141-153.
72. Wonnacott S., Sidhpura N., Balfour D.J. Nicotine: from molecular mechanisms to behaviour. Curr Opin Pharmacol 2005, 5:53-59.
73. Wooters T.E., Bardo M.T. Nicotinic receptors differentially modulate the induction and expression of behavioral sensitization to methylphenidate in rats. Psychopharmacology 2009, 204:551-562.
74. Yoshida K., Engel J.A., Liljequist S. The effect of chronic ethanol administration of high affinity 3H-nicotinic binding in rat brain. Naunyn Schmiedebergs Arch Pharmacol 1982, 321:74-76.
75. Young E.M., Mahler S., Chi H., de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res 2005, 29:58-65.
76. Zakharova E.S., Danysz W., Bespalov A.Y. Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats. Psychopharmacology 2005, 179:128-135.
77. Zhou Q.L., Zhou Q., Forman S.A. The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry 2000, 39:14920-14926.
78. Zuo Y., Kuryatov A., Lindstrom J.M., Yeh J.Z., Narahashi T. Alcohol modulation of neuronal nicotinic acetylcholine receptors is alpha subunit dependent. Alcohol Clin Exp Res 2002, 26:779-784.