Nicotinic receptor pore mutations create a sensitive inhibitory site for ethanol

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 9, 2000, Pages 1363-1368

  Forman, Stuart A ^a   Zhou, Qing ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acetylcholine; Alcohol; Ion Channel; Serotonin; Aminobutyric Acid

Indexed keywords

ACETYLCHOLINE; ION CHANNEL; ISOLEUCINE; NICOTINIC RECEPTOR; SERINE;

ALCOHOLISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; HYDROPHOBICITY; ION CONDUCTANCE; ION TRANSPORT; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY; SITE DIRECTED MUTAGENESIS;

EID: 0033828861     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02104.x     Document Type: Article

References (29)

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7. Effects of general anesthetics on acetylcholine receptor channels
8. Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore
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13. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue
14. A simple method for displaying the hydropathic character of a protein
15. Ethanol inhibits NMDA-activated ion current in hippocampal neurons
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19. Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol
20. The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: Implications for the alpha-helical organization of regions MII and for the structure of the ion channel
21. Molecular similarity analysis: An alternative approach to studying molecular mechanisms of anaesthesia
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23. Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor
24. Unifying characteristics of sites of anesthetic action revealed by combined use of anesthetics and non-anesthetics
25. Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors
26. Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267
27. Protein volume in solution
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29. Alcohols potentiate the function of 5-HT3 receptor channels on NCB-20 cells by favoring and stabilizing the open channel state