Inhibitory influence of mecamylamine on ethanol withdrawal-induced symptoms in C57BL/6J mice

Behavioural Pharmacology

Volumn 21, Issue 2, 2010, Pages 90-95

  Bhutada, Pravinkumar Satyanarayan ^a   Mundhada, Yogita R ^a   Bansod, Kuldeep U ^a   Umathe, Sudhir N ^b   Kahale, Vivek P ^a   Dixit, Pankaj V ^c   Mundhada, Dharmendra R ^a  

^a Agnihotri College of Pharmacy Wardha   (India)

^b RTM NAGPUR UNIVERSITY   (India)

^c IPS Academy   (India)

Author keywords

Addiction; Diazepam; Ethanol dependence; Ethanol withdrawal; Mouse; Neuronal nicotinic acetylcholine receptor

Indexed keywords

ALCOHOL; DIAZEPAM; MECAMYLAMINE; NICOTINIC RECEPTOR;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; MOUSE; NONHUMAN; SYMPTOM; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

ANIMALS; BEHAVIOR, ANIMAL; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MALE; MECAMYLAMINE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; RECEPTORS, NICOTINIC; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 77949851476     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e328337be54     Document Type: Article

References (60)

1. Ait-Daoud N Jr, Malcolm RJ, Johnson BA (2006). An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants. Addict Behav 31:1628-1649.
2. Alkondon M, Albuquerque EX (2002). A non-a7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons. J Neurophysiol 87:1651-1654.
3. Andreasen JT, Redrobe JP (2009). Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. Behav Pharmacol 20:286-295.
4. Aracri P, Consonni S, Morini R, Perrella M, Rodighiero S, Amadeo A, Becchetti A (2009). Tonic modulation of gaba release by nicotinic acetylcholine receptors in layer v of the murine prefrontal cortex. Cereb Cortex. doi: 10.1093/cercor/ bhp214 [Epub ahead of print]
5. Besheer J, Lepoutre V, Hodge CW (2009). Preclinical evaluation of riluzole: assessments of ethanol self administration and ethanol withdrawal symptoms. Alcohol Clin Exp Res 33:1460-1468.
6. Blomqvist O, Engel JA, Nissbrandt H, Soderpalm B (1993). The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine. Eur J Pharmacol 249:207-213.
7. Blomqvist O, Ericson M, Engel JA, Soderpalm B (1997). Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamyl-amine. Eur J Pharmacol 334:149-156.
8. Book SW, Myrick H (2005). Novel anticonvulsants in the treatment of alcoholism. Expert Opin Investig Drugs 14:371-376.
9. Butt CM, King NM, Stitzel JA, Collins AC (2004). Interaction of the nico-tinic cholinergic system with ethanol withdrawal. J Pharmacol Exp Ther 308:591-599.
10. Champtiaux N, Kalivas PW, Bardo MT (2006). Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats. Behav Brain Res 168:120-126.
11. Clark A, Little HJ (2004). Interactions between low concentrations of ethanol and nicotine on firing rate of ventral tegmental dopamine neurones. Drug Alcohol Depend 75:199-206.
12. Clarke PB, Pert CB, Pert A (1984). Autoradiographic distribution of nicotine receptors in rat brain. Brain Res 323:390-395.
13. Corrigall WA, Franklin KB, Coen KM, Clarke PB (1992). The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 107:285-289.
14. Costall B, Kelly ME, Naylor RJ (1988). The anxiolytic and anxiogenic actions of ethanol in a mouse model. J Pharm Pharmacol 40:197-202.
15. De Biasi M, Salas R (2008). Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal. Exp Biol Med (Maywood) 233:917-929.
16. El Yacoubi M, Ledent C, Parmentier M, Daoust M, Costentin J, Vaugeois J (2001). Absence of the adenosine A2A receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice. Neuropharmacology 40:424-432.
17. Faingold CL, N'Gouemo P, Riaz A (1998). Ethanol and neurotransmitter interactions from molecular to integrative effects. Prog Neurobiol 55:509-535.
18. File SE, Zharkovsky A, Hitchcott PK (1992). Effects of nitrendipine, chlordiazep-oxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 16:87-93.
19. Ford MM, Fretwell AM, Nickel JD, Mark GP, Strong MN, Yoneyama N, Finn DA (2009). The influence of mecamylamine on ethanol and sucrose self-administration. Neuropharmacology 57:250-258.
20. Fu H, Dou J, Li W, Luo J, Li KC, Lam CS, et al. (2008). Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic independent mechanisms. Neuropharmacology 54:755-765.
21. Gatch MB, Lal H (1998). Pharmacological treatment of alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 22:917-944.
22. Goldstein DB, Pal N (1971). Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction. Science 172:288-290.
23. Gothoni P (1983). Hypersensitivity to tremorogenic action of nicotine in rats withdrawn from ethanol. Med Biol 61:344-345.
24. Gothoni P, Ikola W (1985). Ethanol withdrawal tremor potentiates the tremoro-genic actions of nicotine. Med Biol 63:131-136.
25. Gulliver SB, Kamholz BW, Helstrom AW (2006). Smoking cessation and alcohol abstinence: what do the data tell us? Alcohol Res Health 29:208-212.
26. Imperato A, Di Chirata G (1986). Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239:219-228.
27. Imperato A, Mulas A, Di Chirata G (1986). Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur J Pharmacol 132:337-338.
28. Jung ME, Wallis CJ, Gatch MB, Lal H (2000). Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol withdrawal. Alcohol 21:161-168.
29. Kamens HM, Phillips TJ (2008). A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine-or methampheta-mine-induced stimulation. Psychopharmacology 196:377-387.
30. Kanno T, Yaguchi T, Yamamoto S, Nagata T, Yamomoto H, Fugikawa H, Nishizaki T (2005). Bidirectional regulations for glutamate and GABA release in the hippocampus by a7 and non-a7 receptors. Biochem Biophys Res Commun 338:742-747.
31. Kayir H, Uzbay T (2008). Effects of clozapine on ethanol withdrawal syndrome in rats. Alcohol Alcohol 43:619-625.
32. Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP (2001). Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21:1452-1463.
33. Kuzmin A, Jerlhag E, Liljequist S, Engel J (2009). Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior. Psychopharmacology 203:99-108.
34. Larsson A, Engel JA (2004). Neurochemical and behavioral studies on ethanol and nicotine interactions. Neurosci Biobehav Rev 27:713-720.
35. Larsson A, Svensson L, Sö derpalm B, Engel JA (2002). Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice. Alcohol 28:157-167.
36. Le AD, Corrigall WA, Harding JW, Juzytsch W, Li TK (2000). Involvementof nicotinic receptors in alcohol self-administration. Alcohol Clin Exp Res 24:155-163.
37. Lippiello PM, Beaver JS, Gatto GJ, James JW, Jordan KG, Traina VM, et al. (2008). TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther 14:266-277.
38. Longo LP, Campbell T, Hubatch S (2002). Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention. J Addict Dis 21:55-64.
39. Mayo-Smith MF (1997). Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA 278:144-151.
40. McDonough JH, Shih T (1995). A study of the iv-methyl-d-aspartate antagonistic properties of anticholinergic drugs. Pharmacol Biochem Behav 51:249-253.
41. Miller DK, Segert IL (2005). Mecamylamine attenuates ephedrine induced hyperactivity in rats. Pharmacol Biochem Behav 81:165-169.
42. Nadal R, Chappell AM, Samson HH (1998). Effects of nicotine and mecamyl-amine microinjections into the nucleus accumbens on ethanol and sucrose self administration. Alcohol Clin Exp Res 22:1190-1198.
43. Nagy J (2008). Alcohol related changes in regulation of NMDA receptor functions. Curr Neuropharmacol 6:39-54.
44. Narahashi T, Aistrup GL, Marszalec W, Nagata K (1999). Neuronal nicotinic acetyl-choline receptors: a new target site of ethanol. Neurochem Int 35:131-141.
45. Newman MB, Manresa JJ, Sanberg PR, Shytle RD (2001). Nicotine induced seizures blocked by mecamylamine and its stereoisomers. Life Sci 69:2583-2591.
46. O'Dell TJ, Christensen BN (1988). Mecamylamine is a selective noncompetitive antagonist of N-methyl-D-aspartate-and aspartate induced currents in horizontal cells dissociated from the catfish retina. Neurosci Lett 94:93-98.
47. Piasecki TM, Jorenby DE, Smith SS, Fiore MC, Baker TB (2003). Smoking withdrawal dynamics. I. Abstinence distress in lapsers and abstainers. J Abnorm Psychol 112:3-13.
48. Ribeiro-Carvalho A, Lima CS, Medeiros AH, Siqueira NR, Filgueiras CC, Manhães AC, Abreu-Villaç a DY (2009). Combined exposure to nicotine and ethanol in adolescent mice: effects on the central cholinergic systems during short and long term withdrawal. Neuroscience 162:1174-1186.
49. Umathe SN, Bhutada PS, Dixit PV, Jain NS (2008). Leuprolide-a luteinizing hormone-releasing hormone agonist attenuates ethanol-withdrawal syndrome and ethanol-induced locomotor sensitization in mice. Neuropeptides 42:345-353.
50. Unsalan N, Saglam E, Kayir H, Uzbay T (2008). Efects of olanzepine on ethanol withdrawal syndrome in rats. Eur J Pharmacol 579:208-214.
51. Uzbay IT (2008). Serotonergic anti-depressants and ethanol withdrawal syndrome: a review. Alcohol Alcohol 43:15-24.
52. Verleye M, Heulard I, Gillardin JM (2009). The anxiolytic etifoxine protects against convulsant and anxiogenic aspects of the alcohol withdrawal syndrome in mice. Alcohol 43:197-206.
53. West RJ, Hajek P, Belcher M (1989). Severity of withdrawal symptoms as a predictor of outcome of an attempt to quit smoking. Psychol Med 19:981-985.
54. WHO (2004). Global status report on alcohol. World Health Organization, Department of Mental Health and Substance Abuse; http://www.who.int/ substance-abuse/publications/global-status-report-2004-overview.pdf. [Accessed June 2009]
55. Wonnacott S, Sidhpura N, Balfour DJ (2005). Nicotine: from molecular mechanisms to behaviour. Curr Opin Pharmacol 5:53-59.
56. Wooters TE, Bardo MT (2009). Nicotinic receptors differentially modulate the induction and expression of behavioral sensitization to methylphenidate in rats. Psychopharmacology 204:551-562.
57. Yoshida K, Engel JA, Liljequist S (1982). The effect of chronic ethanol administration of high affinity 3H-nicotinic binding in rat brain. Naunyn Schmiedebergs Arch Pharmacol 321:74-76.
58. Young EM, Mahler S, Chi H, de Wit H (2005). Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res 29:58-65.
59. Zakharova ES, Danysz W, Bespalov AY (2005). Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats. Psychopharmacology 179:128-135.
60. Zarrindast MR, Solati J, Oryan S, Parivar K (2008). Effect of intra-amygdala injection of nicotine and GABA receptor agents on anxiety-like behaviour in rats. Pharmacology 82:276-284.