Mecamylamine but not the α7 receptor antagonist α-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine

British Journal of Pharmacology

Volumn 131, Issue 5, 2000, Pages 997-1003

  Kempsill, F E J ^a   Pratt, J A ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Autoradiography; Locomotor activity; Mecamylamine; Nicotine; Sensitization; bungarotoxin; 7 receptors

Indexed keywords

ALPHA BUNGAROTOXIN; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; BUNGAROTOXIN; NICOTINIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN DEPTH STIMULATION; CONVULSION; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; BRAIN; DRUG EFFECT; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; BUNGAROTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MECAMYLAMINE; MOTOR ACTIVITY; NICOTINE; NICOTINIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

EID: 0033626001     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703560     Document Type: Article

References (36)

1. Sensitization of the mesoaccumbens response to nicotine
2. The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity
3. Desensitisation of nicotine-induced mesolimbic dopamine during constant infusion with nicotine
4. Nicotine cue: Lack of effect of the α 7 nicotinic receptor antagonist methyllycaconitine
5. Dopaminergic mechanisms in the locomotor stimulant effects of nicotine
6. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats
7. 125I]α-bungarotoxin
8. Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists
9. Nicotine tolerance: An analysis of the time course of its development and loss in the rat
10. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
11. Immunocytochemical localisation of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system
12. Methyllycaconitine: A novel nicotinic antagonist
13. α-Bungarotoxin binding to hippocampal interneurons: Immunocytochemical characterisation and effects on growth factor expression
14. α-Bungarotoxin binding in relation to functional organisation of the rat suprachiasmatic nucleus
15. Hippocampal synaptic transmission enhanced by low concentrations of nicotione
16. Failure of α-bungarotoxin to modify nicotine-induced changes in locomotor activity in rats
17. Effects of chronic nicotine infusion on tolerance development and nicotinic receptors
18. Variation of nicotinic binding sites among inbred strains
19. Time course study of the effects of chronic nicotine infusion on drug response and brain receptors
20. Nine residues influence the binding of α-bungarotoxin in the α-subunit region 185-200 of the human muscle acetylcholine receptor
21. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
22. Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors
23. The nicotinic receptor agonists (-)-nicotine and isoarecolone differ in their effects on dopamine release in the nucleus accumbens
24. Nicotine withdrawal in the rat: Role of alpha 7 nicotinic receptors in the ventral tegmental area
25. Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission
26. Locomotor activity in rats after administration of nicotine intracerebrally
27. Behavioural effects of nicotinic agonists N-(3-pyridylmethyl)pyrrolidine and isoarecolone in rats
28. The neural basis of drug craving: An incentive-sensitization theory of addiction
29. The diversity of neuronal nicotinic acetylcholine receptors
30. Molecular cloning, functional properties, and distribution of rat brain α7: A nicotinic cation channel highly permeable to calcium
31. Behavioural and neurochemical adaptations to nicotine in rats: Influence of NMDA antagonists
32. Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms
33. Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat
34. Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats
35. Nicotine: Not just for cigarettes anymore
36. Nicotinic acetylcholine receptors in separate brain regions exhibit different affinities for methyllycaconitine