Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth

Journal of Investigative Dermatology

Volumn 130, Issue 8, 2010, Pages 2031-2040

  Stoll, Stefan W ^a   Johnson, Jessica L ^a   Li, Yong ^a   Rittié, Laure ^a   Elder, James T ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; CYTOKERATIN 1; CYTOKERATIN 10; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; SHORT HAIRPIN RNA; TETRACYCLINE; VASCULOTROPIN INHIBITOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; LENTIVIRINAE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 77954759827     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.98     Document Type: Article

References (50)

1. Adam R, Drummond DR, Solic N et al. (1995) Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail. Biochim Biophys Acta 1266:83-90
2. Barnard JA, Graves Deal R, Pittelkow MR et al. (1994) Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J Biol Chem 269:22817-22822
3. Bhagavathula N, Nerusu KC, Fisher GJ et al. (2005) Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient mice. Am J Pathol 166:1009-1016
4. Boonstra J, De Laat SW, Ponec M (1985) Epidermal growth factor receptor expression related to differentiation capacity in normal and transformed keratinocytes. Exp Cell Res 161:421-433
5. Brown CL, Meise KS, Plowman GD et al. (1998) Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metallopro-tease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem 273:17258-17268
6. Coffey RJ Jr, Derynck R, Wilcox JN et al. (1987) Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature 328:817-820
7. Cook PW, Brown JR, Cornell KA et al. (2004) Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermisis alsoassociated withsynovitis. Exp Dermatol 13:347-356
8. Cook PW, Mattox PA, Keeble WW et al. (1991) A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphir-egulin. Mol Cell Biol 11:2547-2557
9. Cook PW, Piepkorn M, Clegg CH et al. (1997) Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 100:2286-2294
10. Cook PW, Pittelkow MR, Keeble WW et al. (1992) Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 52:3224-3227
11. De Potter IY, Poumay Y, Squillace KA, et al. (2001) Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation. Exp Cell Res 271:315-328
12. Dechat T, Shimi T, Adam SA et al. (2007) Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc Natl Acad Sci USA 104:4955-4960
13. Dickson MA, Hahn WC, Ino Y et al. (2000) Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 20:1436-1447
14. Dominey AM, Wang XJ, King LE Jr et al. (1993) Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillo-mas. Cell Growth Differ 4:1071-1082
15. Elder JT, Fisher GJ, Lindquist PB et al. (1989) Overexpression of transforming growth factor alpha in psoriatic epidermis. Science 243:811-814
16. Ferby I, Reschke M, Kudlacek O et al. (2006) Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12:568-573
17. Hashimoto K, Higashiyama S, Asada H et al. (1994) Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 269:20060-20066 (Pubitemid 24250928)
18. Hinkle CL, Sunnarborg SW, Loiselle D et al. (2004) Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem 279:24179-24188
19. Hovanessian AG (2007) On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2′-5′oligoadenylate synthetases and the protein kinase PKR. Cytokine Growth Factor Rev 18:351-361
20. lordanov MS, Choi RJ, Ryabinina OP et al. (2002) The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol Cell Biol 22:5380-5394
21. Isokane M, Hieda M, Hirakawa S et al. (2008) Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. J Cell Sci 121:3608-3618
22. Kansra S, Stoll SW, Johnson JL et al. (2004) Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Mol Biol Cell 15:4299-4309
23. Katoh Y, Katoh M (2006) Canonical WNT signaling pathway and human AREG. Int J Mol Med 17:1163-1166
24. Kim DS, Lee HK, Park SH et al. (2008) Terrein inhibits keratinocyte proliferation via ERK inactivation and G2/M cell cycle arrest. Exp Dermatol 17:312-317
25. Kochupurakkal BS, Harari D, Di-Segni A, et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 280:8503-8512
26. Laborda J (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 19:3998
27. Marques MM, Martinez N, Rodriguez-Garcia I et al. (1999) EGFR family-mediated signal transduction in the human keratinocyte cell line HaCaT. Exp Cell Res 252:432-438
28. Minner F, Poumay Y (2009) Candidate housekeeping genes require evaluation before their selection for studies of human epidermal keratinocytes. J Invest Dermatol 129:770-773
29. Nanba D, Mammoto A, Hashimoto K et al. (2003) Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol 163:489-502
30. Olayioye MA, Neve RM, Lane HA et al. (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19:3159-3167
31. PastoreS,MasciaF,MarianiVet al. (2008) The epidermal growth factor receptor system in skin repair and inflammation. JInvestDermatol 128:1365-1374
32. Peschon JJ, Slack JL, Reddy P et al. (1998) An essential role for ectodomain shedding in mammalian development [see comments]. Science282:1281-1284
33. Peus D, Hamacher L, Pittelkow MR (1997) EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation. J Invest Dermatol 109:751-756
34. Piepkorn M, Lo C, Plowman G (1994) Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans. J Cell Physiol 159:114-120
35. Piepkorn M, Predd H, Underwood R, et al. (2003) Proliferation- differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. Arch Dermatol Res 295:93-101
36. Pittelkow MR, Cook PW, Shipley GD et al. (1993) Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth Differ 4:513-521
37. Poumay Y, Pittelkow MR (1995) Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins. J Invest Dermatol 104:271-276
38. Rittie L, Stoll SW, Kang S, et al. (2009) Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. Aging Cell 8:738-751
39. Sahin U, Weskamp G, Kelly K et al. (2004) Distinct roles for ADAM10 and ADA-M17 in ectodomain shedding of six EGFR ligands. JCellBiol 164:769-779
40. Sanderson MP, Dempsey PJ, Dunbar AJ (2006) Control of ErbB signaling through metalloproteinase mediated ectodomain shedding of EGF-like factors. Growth Factors 24:121-136
41. Shirakata Y, Komurasaki T, Toyoda H et al. (2000) Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem 275:5748-5753
42. Shoyab M, McDonald VL, Bradley JG et al. (1988) Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci USA 85:6528-6532
43. Stoll SW, Elder JT (1998) Retinoid regulation of heparin-binding EGF-like growth factor expression in human keratinocytes and skin. Exp Dermatology 7:391-397
44. Stoll SW, Johnson JL, Bhasin A et al. (2010) Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin. J Invest Dermatol 130:295-304
45. Stoll SW, Kansra S, Peshick S et al. (2001) Differential utilization and localization of ErbB receptor tyrosine kinase activities in intact skin compared to normal and malignant keratinocytes. Neoplasia 3:339-350
46. Strachan L, Murison JG, Prestidge RL et al. (2001) Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily. JBiol Chem 276:18265-18271
47. Sunnarborg SW, Hinkle CL, Stevenson M et al. (2002) Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. JBiol Chem 277:12838-12845
48. Tokumaru S, Higashiyama S, Endo T et al. (2000) Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. JCell Biol 151:209-220
49. Vassar R, Fuchs E (1991) Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev 5:714-727
50. Yan Y, Shirakabe K, Werb Z (2002) The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. JCell Biol 158:221-226