Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes

Archives of Dermatological Research

Volumn 295, Issue 3, 2003, Pages 93-101

  Piepkorn, Michael ^a   Predd, Holly ^a   Underwood, Robert ^a   Cook, Paul ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Cascade Biologics Inc   (United States)

Author keywords

Epidermis; Heparin binding epidermal growth factor; Keratinocytes

Indexed keywords

AMPHIREGULIN; BETACELLULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; NEU DIFFERENTIATION FACTOR;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; EPIDERMIS; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; KERATINOCYTE; LABELING INDEX; MORPHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PSORIASIS; RECEPTOR DOWN REGULATION;

CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; EPIDERMIS; HEPARIN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; NEUREGULIN-1; PSORIASIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; TISSUE DISTRIBUTION;

EID: 0042659624     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-003-0391-x     Document Type: Article

References (28)

1. Ahmed NU, Ueda M, Ichihashi M (1997) Increased level of c-erbB-2/neu/HER-2 protein in cutaneous squamous cell carcinoma. Br J Dermatol 136:908-912
2. Castagnino P, Lorenzi MV, Yeh J, Breckenridge D, Sakata H, Munz B, Werner S, Bottaro D (2000) Neu differentiation factor/heregulin induction by hepatocyte and keratinocytes growth factors. Oncogene 19:640-648
3. Cook PW, Piepkorn M, Clegg CH, Plowman GD, DeMay JM, Brown JR, Pittelkow MR (1997) Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 100:2286-2294
4. Danilenko DM, Ring BD, Lu JZ, Tarpley JE, Chang D, Liu N, Wen D, Pierce GF (1995) Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds. J Clin Invest 95:842-851
5. De Potter IY, Poumay Y, Squillace KA, Pittelkow MR (2001) Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation. Exp Cell Res 271:315-328
6. Dlugosz AA, Cheng C, Williams EK, Darwiche N, Dempsey PJ, Mann B, Dunn AR, Coffey RJ Jr, Yuspa SH (1995) Autocrine transforming growth factor alpha is dispensible for v-rasHA-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res 55:1883-1893
7. Garach-Jehoshua O, Ravid A, Liberman UA, Koren R (1999) 1,25-Dihydroxyvitamin D3 increases the growth-promoting activity of autocrine epidermal growth factor receptor ligands in keratinocytes. Endocrinology 140:713-721
8. Hashimoto Y, Higashiyama S, Asada H, et al (1994) Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 269:20060-20066
9. Kiguchi K, Beltran L, Rupp T, DiGiovanni J (1998) Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol. Mol Carcinog 22:73-83
10. Kilpi A, Rich AM, Konttinen YT, Reade PC (1995) The expression of c-erbB-2 protein in the keratinocytes of oral mucosal lichen planus. Br J Dermatol 133:847-852
11. Marikovsky M, Lavi S, Pinkas-Kramarski R, Karunagaran D, Liu N, Wen D, Yarden Y (1995) ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene 10:1403-1411
12. Marques MM, Martinez N, Rodriguez-Garcia I, Alonso A (1999) EGFR family-mediated signal transduction in the human keratinocyte cell line HaCaT. Exp Cell Res 252:432-438
13. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-341
14. Nanney LB, Stoscheck CM, King LE Jr, Underwood RA, Holbrook KA (1990) Immunolocalization of epidermal growth factor receptors in normal developing human skin. J Invest Dermatol 94:742-748
15. Nylander N, Smith LT, Underwood RA, Piepkorn M (1998) Topography of amphiregulin expression in cultured human keratinocytes: colocalization with the epidermal growth factor receptor and CD44. In Vitro Cell Dev Biol 34:183-189
16. Peus D, Hamacher L, Pittelkow M (1997) EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation. J Invest Dermatol 109:751-756
17. Piepkorn M (1996) Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol 18:165-171
18. Piepkorn M, Lo C, Plowman G (1994) Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans. J Cell Physiol 159:114-120
19. Piepkorn M, Pittelkow MR, Cook PW (1998) Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors. J Invest Dermatol 111:715-721
20. Porter RM, Lunny DP, Ogden PH, Morley SM, McLean WHI, Evans A, Harrison DL, Rugg EL, Lane EB (2000) K15 expression implies lateral differentiation within stratified epithelial basal cells. Lab Invest 80:1701-1710
21. Sakai Y, Nelson KG, Snedeker S, Bossert NL, Walker W, McLachlan J, Di Augustine RP (1994) Expression of epidermal growth factor in suprabasal cells of stratified squamous epithelia: implications for a role in differentiation. Cell Growth Differ 5:527-535
22. Schelfhout VRJ, Coene ED, Delaey B, Thys S, Page DL, De Potter CR (2000) Pathogenesis of Paget's disease: epidermal heregulin α, motility factor, and the HER receptor family. J Natl Cancer Inst 92:622-627
23. Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238
24. Stoll SW, Elder JT (1998) Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin. Exp Dermatol 7:391-397
25. Stoll SW, Elder JT (1999) Differential regulation of EGF-like growth factor genes in human keratinocytes. Biochem Biophys Res Commun 265:214-221
26. Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT (2001) Differential utilization and localization of erbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia 3:339-350
27. Threadgill DW, Dlugosz AA, Hansen LA, et al (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234
28. Xian W, Rosenberg MP, DiGiovanni J (1997) Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion. Oncogene 14:1435-1444