Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation

Experimental Cell Research

Volumn 271, Issue 2, 2001, Pages 315-328

  De Potter, Isabelle Y ^a   Poumay, Yves ^a   Squillace, Karen A ^b   Pittelkow, Mark R ^b  

^a UNIVERSITY OF NAMUR   (Belgium)

^b MAYO CLINIC   (United States)

Author keywords

Differentiation; HER; Heregulin; Keratinocyte; Neuregulin

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEREGULIN ALPHA; HEREGULIN BETA; LIGAND; NEU DIFFERENTIATION FACTOR; PROTEIN HER3; PROTEIN HER4; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CELL DAMAGE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVATION; EPIDERMIS CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0035842423     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5390     Document Type: Article

References (68)

1. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
2. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
3. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
4. Neu and its ligands: From an oncogene to neural factors
5. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors
6. Ligand specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family
7. Isolation of the neu/HER2 stimulatory ligand: A 44 kD glycoprotein that induces differentiation of mammary tumor cells
8. Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
9. Identification of heregulin, a specific activator of p185erbB2
10. NDF/heregulin stimulates the phosphorylation of HER3/erbB3
11. Heregulin induces tyrosine-phosphorylation of HER4/p180erbB4
12. Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships
13. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
14. A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
15. Transforming growth factor-α and related growth factors
16. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
17. Strain-dependent epithelial defects in mice lacking the EGF receptor
18. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
19. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes
20. Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: Clonal analyses, growth kinetics, and cell cycle studies
21. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin
22. Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy
23. Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins
24. Distribution of neu (c-erbB-2) protein in human, skin
25. Expression of the HER-2/neu protooncogene in normal human adult and fetal tissues
26. Expression of the c-erbB-3 protein in normal human adult and fetal tissues
27. Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: Possible role in mouse skin tumor promotion
28. Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development
29. ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes
30. Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21
31. Aberrant neural and cardiac development in mice lacking the erbB4 neuregulin receptor
32. Requirement for neuregulin receptor erbB2 in neural and cardiac development
33. Multiple essential functions of neuregulin in development
34. Severe neuropathies in mice with targeted mutations in the erbB3 receptor
35. High-cell-density phorbol ester and retinoic acid upregulate involucrin and downregulate supra-basal keratin 10 in autocrine cultures of human epidermal keratinocytes
36. A cellular oncogene (c-Ki-ras) is amplified, overexpressed and located with karyotypic abnormalities in mouse adrenocortical tumor cells
37. Structural and functional aspects of the multiplicity of neu differentiation factors
38. Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis
39. Structure and evolution of the human involucrin gene
40. Isolation of a GC-rich cDNA identifying mRNA present in human epidermis and modulated by calcium and retinoic acid in cultured keratinocytes. Homology with murine loricrin mRNA
41. p1B15: A cDNA clone of the rat mRNA encoding cyclophilin
42. Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds
43. Inhibition of basal cell proliferation during storage of detached cultured epidermal keratinocyte sheets
44. Protein measurements with Folin phenol reagent
45. Human epidermal keratinocytes upregulate expression of the prolactin receptor after the onset of terminal differentiation, but do not respond to prolactin
46. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases
47. Signal transduction by receptors with tyrosine kinase activity
48. Growth factor-independent proliferation of normal neonatal keratinocytes: Production of autocrine- and paracrine-acting mitogenic factors
49. Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
50. Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the α2 integrin subunit
51. EGF-receptor tyrosine kinase inhibition induces keratinocyte growth arrest and terminal differentiation
52. Gene expression profiles in normal and cancer cells
53. EGFR family-mediated signal transduction in the human keratinocyte cell line HaCaT
54. Biological responses to erbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression
55. Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors
56. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
57. Adhesive properties of human basal epidermal cells: An analysis of keratinocyte stem cells, transit amplifying cells, and postmitotic differentiating cells
58. Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice
59. Neuregulin and erbB receptors play a critical role in neuronal migration
60. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
61. Stimulation of β1-integrin function by epidermal growth factor and heregulin-β has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase
62. The tetraspanin CD9 associates with the integrin α6β4 in cultured human epidermal keratinocytes and is involved in cell motility
63. α6β4 and α6β1 integrins associate with erbB-2 in human carcinoma cell lines
64. Inhibitory role of α6β4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on α3β1 integrin
65. Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis
66. Expression of the integrin-linked kinase (ILK) in mouse skin. Loss of expression in suprabasal layers of the epidermis and up-regulation by erbB-2
67. Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicit striking developmental abnormalities in the epidermis and hair follicles
68. Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing the neu oncogene under the control of the bovine keratin 5 promoter