Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: Molecular recognition loci for the pharmacophore and address components of kappa antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1573-1576

  Larson, Dennis L ^a   Jones, Robert M ^a   Hjorth, Siv A ^b   Schwartz, Thue W ^b   Portoghese, Philip S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR; NORBINALTORPHIMINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN COS1; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PHARMACOPHORE; PROTEIN DOMAIN; REACTION ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; CLONING, MOLECULAR; COS CELLS; GLUTAMIC ACID; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NALTREXONE; NARCOTIC ANTAGONISTS; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0034692171     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000059g     Document Type: Article

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