Identification of an opioid κ receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Journal of Medicinal Chemistry

Volumn 41, Issue 26, 1998, Pages 5188-5197

  Thomas, James B ^a   Fall, Michael J ^a   Cooper, Julie B ^a   Rothman, Richard B ^b   Mascarella, S Wayne ^a   Xu, Heng ^b   Partilla, John S ^b   Dersch, Christina M ^b   McCullough, Karen B ^b   Cantrell, Buddy E ^c   Zimmerman, Dennis M ^c   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

^b NIDA Addiction Research Center   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 HYDROXYPHENYL) N [2 [4 (3 HYDROXYPHENYL) 3,4 DIMETHYL 1 PIPERIDINYL] 1 ISOPROPYLETHYL]PROPIONAMIDE; DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; GUANOSINE TRIPHOSPHATE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N (4 PHENYL 2 BUTENYL)DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; N [[3 (4 HYDROXYPHENYL)PROPANAMIDO] 3' METHYLBUTYL]DIMETHYL 4 (3 HYDROXYPHENYL)PIPERIDINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; PIPERIDINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; HYDROGEN BOND; LIGAND BINDING; PROTEIN ANALYSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; LACTONES; LIGANDS; NARCOTIC ANTAGONISTS; PIPERIDINES; PUTAMEN; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032542315     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980511k     Document Type: Article

References (20)

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