Anti-inflammatory pro-resolving derivatives of omega-3 and omega-6 polyunsaturated fatty acids;Przeciwzapalne "prowygaszeniowe" pochodne wielonienasyconych kwasów tłuszczowych omega 3 i omega 6

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 64, Issue , 2010, Pages 115-132

  Nowak, Jerzy Z ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Inflammation; Lipoxins; Maresin; Omega 6 and omega 3 polyunsaturated fatty acids; Pro resolving mediators; Protectin; Resolvins

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; CD59 ANTIGEN; LIPOXIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

HUMAN; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; REVIEW;

ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD59; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOXINS;

EID: 77954697249     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Adir-Kirk T. L., Senior R. M.: Fragment sof extracellular matrix as mediators of inflammation. Int. J. Biochem. Cell Biol., 2008;40:1101-1110
2. Arita M., Bianchini F., Aliberti J., Sher A., Chiang N., Hong S., Yang R., Petasis N. A., Serhan C. N.: Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J. Exp. Med., 2005;201:713-722 (Pubitemid 40395117)
3. Arita M., Ohira T., Sun Y. P., Elangovan S., Chiang N., Serhan C. N.: Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J. Immunol., 2007;178:3912-3917 (Pubitemid 46417661)
4. Bannenberg G. L., Chiang N., Ariel A., Tjonahen E., Gotlinger K. H., Hong S., Serhan C. N.: Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol., 2005;174:4345-4355 (Pubitemid 40396017)
5. Bazan N. G.: Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot. Essent. Fatty Acids., 2009;81:205-211
6. Bazan N. G., Birkle D. L., Reddy T. S.: Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina. Biochem. Biophys. Res. Commun., 1984;125:741-747 (Pubitemid 15155759)
7. Bradlay J. R.: TNF-mediated inflammatory disease. J. Pathol., 2008;214:149-160
8. Calder P. C.: Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie, 2009;91:791-795
9. Całkosiński I., Dobrzyński M., Cał kosińska M., Seweryn E., Bronowicka-Szydełko A., Dzierzba K., Ceremuga I., Gamian A.: Charakterystyka odczynu zapalnego. Post. Hig. Med. Dośw., 2009;63:395-408
10. Cash J. L., Hart R., Russ A., Dixon J. P., Colledge W. H., Doran J., Hendrick A. G., Carlton M. B., Greaves D. R.: Synthetic chemerin-derived peptides suppress inflammation through Chem R23. J. Exp. Med., 2008;205:767-775 (Pubitemid 351549876)
11. Chiang N., Serhan C. N., Dahlen S. E., Drazen J. M., Hay D. W., Rovati G. E., Shimizu T., Yokomizo T., Brink C.: The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol. Rev., 2006;58:463-487 (Pubitemid 44394909)
12. Claria J., Serhan C. N.: Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc. Natl. Acad. Sci. USA, 1995;92:9475-9479
13. Clish C. B., Levy B. D., Chiang N., Tai H. H., Serhan C. N.: Oxi do reductases in lipoxin A4 metabolic inactivation. J. Biol. Chem., 2000;275:25372-25380
14. Clish C. B., O'Brien J. A., Gronert K., Stahl G. L., Petasis N. A., Serhan C. N.: Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. Proc. Natl. Acad. Sci. USA, 1999;96:8247-8252 (Pubitemid 29328440)
15. Connor K. M., SanGiovanni J. P., Lofqvist C., Aderman C. M., Chen J., Higuchi A., Hong S., Pravda E. A., Majchrzak S., Carper D., Hellstrom A., Kang J. X., Chew E. Y., Salem N., Serhan C. N., Smith L. E.: Increased dietary intake of ω-3 polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat. Med., 2007;13:868-873 (Pubitemid 47038185)
16. Dangi B., Obeng M., Nauroth J. M., Chung G., Bailey-Hall E., Hallenbeck T., Arterburn L. M.: Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6). Biochem. Pharmacol., 2009;79:251-260
17. Dangi B., Obeng M., Nauroth J. M., Teymourlouei M., Needham M., Raman K., Arterburn L. M.: Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6). J. Biol. Chem., 2009;284:14744-14759
18. Dona M., Fredman G., Schwab J. M., Chiang N., Arita M., Goodarzi A., Cheng G., von Andrian U. H., Serhan C. N.: Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood, 2008;112:848-855
19. Duffield J. S., Hong S., Vaidya V., Lu Y., Fredman G., Serhan C. N., Bonventre J. V.: Resolvin D series and protectin D1 mitigate acute kidney injury. J. Immunol., 2006;177:5902-5911 (Pubitemid 44628803)
20. Fiore S., Maddox J. F., Perez H. D., Serhan C. N.: Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. J. Exp. Med., 1994;180:253-260 (Pubitemid 24181074)
21. Glaros T., Larsen M., Li L.: Macrophages and fibroblasts during inflammation, tissue damage and organ injury. Front. Biosci., 2009;14:3988-3993
22. Jin Y., Arita M., Zhang Q., Saban D. R., Chauhan S. K., Chiang N., Serhan C. N., Dana R.: Anti-angiogenesis effect of the novel antiinflammatory and pro-resolving lipid mediators. Invest. Ophthalmol. Vis. Sci., 2009;50:4743-4752
23. Kasuga K., Yang R., Porter T. F., Agrawal N., Petasis N. A., Irimia D., Toner M., Serhan C. N.: Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol., 2008;181:8677-8687
24. Kelly M., Hwang J. M., Kubes P.: Modulating leukocyte recruitment in inflammation. J. Allergy Clin. Immunol., 2007;120:3-10 (Pubitemid 46990511)
25. Klaska I., Nowak J. Z.: Rola układu dopełniacza w fizjologii i patologii. Post. Hig. Med. Dośw., 2007;61:167-77
26. Levy B. D., Lukacs N. W., Berlin A. A., Schmidt B., Guilford W. J., Serhan C. N., Parkinson J. F.: Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J., 2007;21:3877-3884 (Pubitemid 350232345)
27. Libby P., Ridker P. M., Hansson G. K.: Inflammation in atherosclerosis: from pathophysiology to practice. J. Am. Coll. Cardiol., 2009;54:2129-2138
28. Lukiw W. J., Cui J. G., Marcheselli V. L., Bodker M., Botkjaer A., Gotlinger K., Serhan C. N., Bazan N. G.: A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J. Clin. Invest., 2005;115:2774-2783 (Pubitemid 41434404)
29. Marcheselli V. L., Hong S., Lukiw W. J., Tian X. H., Gronert K., Musto A., Hardy M., Gimenez J. M., Chiang N., Serhan C. N., Bazan N. G.: Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J. Biol. Chem., 2003;278:43807-43817 (Pubitemid 37346009)
30. Markiewski M. M., Lambris J. D.: The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am. J. Pathol., 2007;171:715-727 (Pubitemid 47440971)
31. Martins V., Valenca S. S., Farias-Filho F. A., Molinaro R., Simoes R. L., Ferreira T. P., e Silva P. M., Hogaboam C. M., Kunkel S. L., Fierro I. M., Canetti C., Benjamin C. F.: ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis. J. Immunol., 2009;182:5374-5381
32. Medzhitov R.: Origin and physiological roles of inflammation. Nature, 2008;454:428-435
33. Mukherjee P. K., Marcheselli V. L., Barreiro S., Hu J., Bok D., Bazan N. G.: Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc. Natl. Acad. Sci. USA, 2007;104:13152-13157 (Pubitemid 351737608)
34. Mukherjee P. K., Marcheselli V. L., Serhan C. N., Bazan N. G.: Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl. Acad. Sci. USA, 2004;101:8491-8496 (Pubitemid 38736602)
35. Murdoch J. R., Lloyd C. M.: Chronic inflammation and asthma. Mut Res., 2009 (w druku)
36. Nauroth J. M., Van Elswyk M., Liu Y., Arterburn L. M.: Antiinflammatory activity of algal ols containing docosahexaenoic acid (DHA) and omega-6 docosapentaenoic acid (DPAn-6). J. Immunol., 2007;178:101.5
37. Nowak J. Z.: Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol. Rep., 2006;58:353-363 (Pubitemid 44111070)
38. Nowak J. Z.: Podwójne oblicze układu dopełniacza - rozważania o tym jak fzjologiczny mechanizm obronny przeistacza siȩ w reakcjȩ patogenna. W; Neuroimmunologia (red. Basta-Kaim A., Kubera M). Instytut Farmakologii PAN. Kraków 2008:137-162
39. Nowak J. Z.: Zwyrodnienie plamki zwiazane z wiekiem a układ odpornościowy: ile immunologiii jest w AMD? Mag. Lek. Okul., 2009;3(2):102-114
40. Nowak J. Z.: W poszukiwaniu biomarkerów dla zwyrodnienia plamki zwiazanego z wiekiem (AMD). Mag. Lek. Okul., 2009;3(3):132-140
41. Nowak J. Z.: Wielonienasycone kwasy tłuszczowe omega-3 w siatkówce i praktyce medycznej - blaski i cienie. Mag. Lek. Okul., 2009;3(4):208-220
42. Nowak J. Z.: Wielonienasycone kwasy tłuszczowe omega-3: aspekty biochemiczne, funkcjonalne i praktyczne. Farmakoterapia w Psychiatrii i Neurologii, 2009;25:127-146
43. Nowak J. Z.: Wielonienasycone kwasy tłuszczowe omega-3: brać czy nie brać? - oto jest pytanie. A jak brać - to kto powinien, kiedy, ile i dlaczego? Wszechświat, 2010;110:30-40
44. Nowak J. Z.: Pochodne wielonienasyconych kwasów tłuszczowych omega-3 i omega-6 o potencjale przeciwzapalnym i protekcyjnym. Mag. Lek. Okul., 2009;3(5):208-220
45. Nowak J. Z., Bienias W.: Zwyrodnienie plamki zwiazane z wiekiem (AMD): etiopatogeneza i strategie terapeutyczne. Post. Hig. Med. Dośw., 2007;61:83-94
46. Ohira T., Bannenberg G., Arita M., Takahashi M., Ge Q., Van Dyke T. E., Stahl G. L., Serhan C. N., Badwey J. A.: A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J. Immunol., 2004;173:2091-2098 (Pubitemid 38971647)
47. Parkinson J. F.: Lipoxin and synthetic lipoxin analogs: an overview of antiinflammatory functions and new concepts in immunomodulation. Inflamm. Allergy Drug Targets, 2006;5:91-106 (Pubitemid 43796671)
48. Romano M., Recchia I., Recchiuti A.: Lipoxin receptors. Scientific World Journal, 2007;7:1393-1412 (Pubitemid 47435433)
49. Samuelsson B., Dahlen S. E., Lindgren J. A., Rouzer C. A., Serhan C. N.: Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science (Wash DC), 1987;237:1171-1176 (Pubitemid 17131222)
50. Serhan C. N.: Lipoxin biosynthesis and its impact in inflammatory and vascular events. Biochim. Biophys. Acta, 1994;1212:1-25 (Pubitemid 24123884)
51. Serhan C. N.: Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J. Periodontol., 2008;79(8 Suppl.):1520-1526
52. Serhan C. N., Clish C. B., Brannon J., Colgan S. P., Chiang N., Gronert K.: Novel functional sets of lipid-derived mediators with anti-inflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal anti-inflammatory drugs and transcellular processing. J. Exp. Med., 2000;192:1197-1204
53. Serhan C. N., Gotlinger K., Hong S., Lu Y., Siegelman J., Baer T., Yang R., Colgan S. P., Petasis N. A.: Anti-inflammatory actions of neuroprotect in D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J. Immunol., 2006;176:1848-1859 (Pubitemid 43134330)
54. Serhan C. N., Hamberg M., Samuelsson B.: Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. USA, 1984;81:5335-5339 (Pubitemid 14048742)
55. Serhan C. N., Hong S., Gronert K., Colgan S. P., Devchand P. R., Mirick G., Moussignac R. L.: Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J. Exp. Med., 2002;196:1025-1037 (Pubitemid 35231761)
56. Serhan C. N., Yang R., Martinod K., Kasuga K., Pillai P. S., Porter T. F., Oh S. F., Spite M.: Maresins: novel macrophage mediators with potent anti-inflammatory and proresolving actions. J. Exp. Med., 2009;206:15-23
57. Spite M., Summers L., Porter T. F., Srivastava S., Bhatnagar A., Serhan C. N.: ResolvinD1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Br. J. Pharmacol., 2009;158:1062-1073
58. Stachura J.: Zapalenia. W.: Patologia - znaczy słowo o chorobie (red. Stachura J., Domagała W). Polska Akademia Umiejȩtnoś ci - Wydział Lekarski, Kraków 2008, Tom I., str. 57-74
59. Sun Y. P., Oh S. F., Uddin J., Yang R., Gotlinger K., Campbell E., Colgan S. P., Petasis N. A., Serhan C. N.: ResolvinD1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties and enzymatic inactivation. J. Biol. Chem., 2007;282:9323-9334 (Pubitemid 47104612)
60. Tian H., Lu Y., Sherwood A. M., Hongqian D., Hong S.: Resolvins E1 and D1 in choroid-retinal pigment epithelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. Invest. Ophthalmol. Vis. Sci., 2009;50:3613-3620
61. Tjonahen E., Oh S. F., Siegelman J., Elangovan S., Percarpio K. B., Hong S., Arita M., Serhan C. N.: Resolvin E2: identification and antiinflammatory actions: pivotal role of human 5-lipoxygenase in resolving E series biosynthesis. Chem. Biol., 2006;13:1193-1202 (Pubitemid 44750731)
62. Tuppo E. E., Arias H. R.: The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol., 2005;37:289-305 (Pubitemid 39330191)
63. Van Dyke T. E., Korman K. S.: Infammation and factors that may regulate inflammatory response. J. Periodontol., 2008;79(8 Suppl.):1503-1507
64. Whitton P. S.: Inflammation as a causative factor in the aetiology of Parkinson's disease. Br. J. Pharmacol., 2007;150:963-976 (Pubitemid 46628616)
65. Xu H., Chen M., Forrester J. V: Para-inflammation in the aging retina. Prog. Retin. Eye Res., 2009;28:348-368