Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6)

Journal of Biological Chemistry

Volumn 284, Issue 22, 2009, Pages 14744-14759

  Dangi, Bindi ^a   Obeng, Marcus ^a   Nauroth, Julie M ^a   Teymourlouei, Mah ^a,b   Needham, Micah ^a   Raman, Krishna ^a   Arterburn, Linda M ^a,c  

^a Martek Biosciences Corporation   (United States)

^b UNITED STATES PHARMACOPEIA   (United States)

^c Alba Therapeutics Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15-LIPOXYGENASE; ANIMAL MODEL; ANTI-INFLAMMATORY; ANTI-INFLAMMATORY AGENTS; CHEMICAL CHARACTERIZATION; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; EICOSAPENTAENOIC ACID; LIPOXYGENASES; LONG CHAINS; NEW CLASS; ORAL ADMINISTRATION; OXYGENATED DERIVATIVES; OXYLIPINS; REACTION PRODUCTS; TANDEM MASS SPECTROMETRY; UNSATURATED FATTY ACIDS; UV SPECTROPHOTOMETRY;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG PRODUCTS; FATTY ACIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PATHOLOGY; PURIFICATION; SPECTROMETERS; SYNTHESIS (CHEMICAL);

ACIDS;

10,17 DIHYDROXY 4,7,11,13,15 DOCOSAPENTAENOIC ACID; 10,17 DIHYDROXY 4,7,11,13,15,19 DOCOSAHEXAENOIC ACID; 17 HYDROXY 4,7,10,13,15 DOCOSAPENTAENOIC ACID; 17 HYDROXY 4,7,10,13,15,19 DOCOSAHEXAENOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; CERVONIC ACID; FATTY ACID DERIVATIVE; INDOMETACIN; OXYLIPIN; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; FEMALE; INFLAMMATION; MALE; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ANIMAL; BIOSYNTHESIS; CELL MOTION; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; EDEMA; ENZYME SPECIFICITY; ENZYMOLOGY; GRANULOCYTE; ISOLATION AND PURIFICATION; ISOMERISM; KINETICS; LEUKOCYTE; LIQUID CHROMATOGRAPHY; MACROPHAGE; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY; SOYBEAN; SWINE;

ANIMALIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 15-LIPOXYGENASE; CELL MOVEMENT; CHROMATOGRAPHY, LIQUID; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FATTY ACIDS, UNSATURATED; GRANULOCYTES; ISOMERISM; KINETICS; LEUKOCYTES; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; RATS; SOLUBILITY; SOYBEANS; SUBSTRATE SPECIFICITY; SUS SCROFA;

EID: 67649306790     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809014200     Document Type: Article

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