Age-associated changes of appetite-regulating peptides

Geriatrics and Gerontology International

Volumn 10, Issue SUPPL. 1, 2010, Pages

  Akimoto, Saeko ^a   Miyasaka, Kyoko ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b TOKYO KASEI UNIVERSITY   (Japan)

Author keywords

Aging; Food intake; Ghrelin; Neuropeptide Y; Orexin

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; AMYLIN; BOMBESIN; CALCITONIN GENE RELATED PEPTIDE; CHOLECYSTOKININ; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CORTICOTROPIN RELEASING FACTOR; DOPAMINE; FIBROBLAST GROWTH FACTOR; GALANIN; GHRELIN; GLUCAGON LIKE PEPTIDE; GROWTH HORMONE RELEASING FACTOR; HISTAMINE; INSULIN; MELANIN CONCENTRATING HORMONE; NEUROMEDIN U; NEUROPEPTIDE Y; NEUROTENSIN; NORADRENALIN; OREXIN A; OREXIN B; PANCREAS ENZYME; PROTIRELIN; SEROTONIN; SOMATOSTATIN; UROCORTIN; UROCORTIN II; UROCORTIN III; ADRENERGIC RECEPTOR STIMULATING AGENT; NEUROPEPTIDE; OREXINS; SIGNAL PEPTIDE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; DECREASED APPETITE; DRUG EFFECT; ENZYME RELEASE; FOOD INTAKE; HYPOTHALAMUS; INCREASED APPETITE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; ANIMAL; DRUG EFFECTS; EATING; METABOLISM; PHYSIOLOGY; WESTERN BLOTTING; WISTAR RAT;

AGING; ANIMALS; APPETITE; BLOTTING, WESTERN; CHOLECYSTOKININ; EATING; GHRELIN; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDE Y; NEUROPEPTIDES; RATS; RATS, WISTAR; SYMPATHOMIMETICS;

EID: 77954674410     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2010.00587.x     Document Type: Review

References (72)

1. Morley JE. Decreased food intake with aging. J Gerontol A Biol Sci Med Sci 2001, 56:81-88.
2. Morley JE, Silver AJ. Anorexia in the elderly. Neurobiol Aging 1988, 9:9-16.
3. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med 2005, 258:301-327.
4. Dockray GJ. Immunochemical evidence of cholecystokinin-like peptides in brain. Nature 1976, 264(5586):568-570.
5. Crawley JN. Comparative distribution of cholecystokinin and other neuropeptides. Why is this peptide different from all other peptides? Ann N Y Acad Sci 1985, 448:1-8.
6. Hill DR, Shaw TM, Graham W, Woodruff GN. Autoradiographical detection of cholecystokinin-A receptors in primate brain using 125I-Bolton Hunter CCK-8 and 3H-MK-329. J Neurosci 1990, 10(4):1070-1081.
7. Hirosue Y, Inui A, Teranishi A. Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice. Am J Physiol 1993, 265:R481-R486. 3 Pt 2
8. Miyasaka K, Kanai S, Masuda M. Gene expressions of cholecystokinin (CCK) and CCK receptors, and its satiety effect in young and old male rats. Arch Gerontol Geriatr 1995, 21:147-155.
9. Sakurai T, Amemiya A, Ishii M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
10. Saper CB, Swanson LW, Cowan WM. An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat. J Comp Neurol 1979, 183:689-706.
11. Miyasaka K, Masuda M, Kanai S, Sato N, Kurosawa M, Funakoshi A. Central Orexin-A stimulates pancreatic exocrine secretion via the vagus. Pancreas 2002, 25:400-404.
12. Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, Miyasaka K. Orexin-A does not stimulate food intake in old rats. Am J Physiol Gastrointest Liver Physiol 2004, 287:G1182-G1187.
13. Akimoto-Takano S, Sakurai C, Kanai S, Hosoya H, Ohta M, Miyasaka K. Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats. Neuroendocrinology 2005, 82(5-6):256-263.
14. Cluderay JE, Harrison DC, Hervieu GJ. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul Pept 2002, 104:131-144.
15. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 1982, 296:659-660.
16. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
17. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA, O'Donohue TL. The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience 1985, 15:1159-1181.
18. Nakazato M, Murakami N, Date Y. A role for ghrelin in the central regulation of feeding. Nature 2001, 409:194-198.
19. Shintani M, Ogawa Y, Ebihara K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001, 50:227-232.
20. Toshinai K, Date Y, Murakami N. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 2003, 144:1506-1512.
21. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001, 50:707-709.
22. Shiiya T, Nakazato M, Mizuta M. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002, 87:240-244.
23. Thompson NM, Gill DA, Davies R. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004, 145:234-242.
24. Broglio F, Gottero C, Prodam F. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 2004, 89:3062-3065.
25. Wren AM, Small CJ, Ward HL. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000, 141:4325-4328.
26. Wren AM, Small CJ, Abbott CR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001, 50:2540-2547.
27. Wren AM, Seal LJ, Cohen MA. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 86:5992-5995.
28. Aloia JF, Vaswani A, Ma R, Flaster E. Aging in women - the four-compartment model of body composition. Metabolism 1996, 45(1):43-48.
29. Silver AJ, Guillen CP, Kahl MJ, Morley JE. Effect of aging on body fat. J Am Geriatr Soc 1993, 41(3):211-213.
30. Chumlea WC, Garry PJ, Hunt WC, Rhyne RL. Distributions of serial changes in stature and weight in a healthy elderly population. Hum Biol 1988, 60(6):917-925.
31. Vellas BJ, Hunt WC, Romero LJ, Koehler KM, Baumgartner RN, Garry PJ. Changes in nutritional status and patterns of morbidity among free-living elderly persons: a 10-year longitudinal study. Nutrition 1997, 13:515-519.
32. Wurtman JJ, Lieberman H, Tsay R, Nader T, Chew B. Calorie and nutrient intakes of elderly and young subjects measured under identical conditions. J Gerontol 1988, 43(6):B174-B180.
33. Rolls BJ, Dimeo KA, Shide DJ. Age-related impairments in the regulation of food intake. Am J Clin Nutr 1995, 62(5):923-931.
34. Silver AJ, Morley JE. Role of CCK in regulation of food intake. Prog Neurobiol 1991, 36:23-34.
35. Ohta M, Tanaka Y, Masuda M, Miyasaka K, Funakoshi A. Impaired release of cholecystokinin (CCK) from synaptosomes in old rats. Neurosci Lett 1995, 198:161-164.
36. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 374(6505):425-432. Erratum in: 1995, 6521): 479
37. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998, 395(6704):763-770.
38. Montague CT, Farooqi IS, Whitehead JP. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997, 387(6636):903-908.
39. Morley JE, Perry HM, Baumgartner RP, Garry PJ. Leptin, adipose tissue and aging - is there a role for testosterone? J Gerontol A Biol Sci Med Sci 1999, 54(3):B108-B109. discussion B110
40. Ahima RS, Prabakaran D, Mantzoros C. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382(6588):250-252.
41. Wolden-Hanson T, Marck BT, Smith L, Matsumoto AM. Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: association of serum leptin levels with peripheral adiposity. J Gerontol A Biol Sci Med Sci 1999, 54(3):B99-107.
42. Mizuno T, Bergen H, Kleopoulos S, Bauman WA, Mobbs CV. Effects of nutritional status and aging on leptin gene expression in mice: importance of glucose. Horm Metab Res 1996, 28(12):679-684.
43. Li H, Matheny M, Nicolson M, Tumer N, Scarpace PJ. Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes 1997, 46(12):2035-2039.
44. Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 1997, 100(12):3105-3110.
45. Perry HM, Morley JE, Horowitz M, Kaiser FE, Miller DK, Wittert G. Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism 1997, 46(12):1399-1405.
46. Baumgartner RN, Waters DL, Morley JE, Patrick P, Montoya GD, Garry PJ. Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat. Metabolism 1999, 48(3):378-384.
47. Nicklas BJ, Toth MJ, Poehlman ET. Daily energy expenditure is related to plasma leptin concentrations in older African-American women but not men. Diabetes 1997, 46(9):1389-1392.
48. Kohrt WM, Landt M, Birge SJ. Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. J Clin Endocrinol Metab 1996, 81(11):3980-3985.
49. Luukkaa V, Pesonen U, Huhtaniemi I. Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab 1998, 83(9):3243-3246.
50. Korenman SG, Morley JE, Mooradian AD. Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab 1990, 71(4):963-969.
51. Morley JE, Kaiser FE, Perry HM. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997, 46(4):410-413.
52. Sih R, Morley JE, Kaiser FE, Perry HM, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997, 82(6):1661-1667.
53. Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995, 1(9):950-953.
54. Siegel JM. Narcolepsy: a key role for hypocretins (orexins). Cell 1999, 98:409-412.
55. Muroya S, Funahashi H, Yamanaka A. Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 2004, 19:1524-1534.
56. Smart D, Haynes AC, Williams G, Arch JR. Orexins and the treatment of obesity. Eur J Pharmacol 2002, 440:199-212.
57. Willie JT, Chemelli RM, Sinton CM, Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 2001, 24:429-458.
58. Haynes AC, Jackson B, Chapman H. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 2000, 96:45-51.
59. Lin L, Faraco J, Li R. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999, 98:365-376.
60. Porkka-Heiskanen T, Alanko L, Kalinchuk A, Heiskanen S, Stenberg D. The effect of age on prepro-orexin gene expression and contents of orexin A and B in the rat brain. Neurobiol Aging 2004, 25:231-238.
61. Zhang JH, Sampogna S, Morales FR, Chase MH. Age-related changes in hypocretin (orexin) immunoreactivity in the cat brainstem. Brain Res 2002, 930:206-211.
62. Dube MG, Kalra SP, Kalra PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 1999, 842:473-477.
63. Lubkin M, Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun 1998, 253:241-245.
64. Terao A, Apte-Deshpande A, Morairty S, Freund YR, Kilduff TS. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 2002, 332:190-194.
65. Mullins DE, Guzzi M, Xia L, Parker EM. Pharmacological characterization of the cloned neuropeptide Y y(6) receptor. Eur J Pharmacol 2000, 395:87-93.
66. Pralong FP, Gonzales C, Voirol MJ. The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 2002, 16:712-714.
67. Schaffhauser AO, Stricker-Krongrad A, Brunner L. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes 1997, 46:1792-1798.
68. Coppola JD, Horwitz BA, Hamilton J, McDonald RB. Expression of NPY Y1 and Y5 receptors in the hypothalamic paraventricular nucleus of aged Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 2004, 287:R69-R75.
69. Akamizu T, Shinomiya T, Irako T. Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab 2005, 90:6-9.
70. Rigamonti AE, Pincelli AI, Corra B. Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J Endocrinol 2002, 175:R1-R5.
71. Asakawa A, Inui A, Fujimiya M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005, 54:18-24.
72. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005, 85:495-522.