메뉴 건너뛰기




Volumn 202, Issue 2, 2010, Pages 318-329

Dual stimulation of MyD88-dependent toll-like receptors induces synergistically enhanced production of inflammatory cytokines in murine bone marrow-derived dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; CYTOKINE; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE; MYD88 PROTEIN, MOUSE; RECOMBINANT PROTEIN; TLR3 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3;

EID: 77954595083     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653499     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 33750980717 scopus 로고    scopus 로고
    • Current status of short synthetic peptides as vaccines
    • Hans D, Young PR, Fairlie DP. Current status of short synthetic peptides as vaccines. Med Chem 2006; 2:627-646
    • (2006) Med Chem , vol.2 , pp. 627-646
    • Hans, D.1    Young, P.R.2    Fairlie, D.P.3
  • 2
    • 33847080492 scopus 로고    scopus 로고
    • Peptide vaccination given with a Toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors
    • Nava-Parada P, Forni G, Knutson KL, Pease LR, Celis E. Peptide vaccination given with a Toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors. Cancer Res 2007; 67:1326-1334
    • (2007) Cancer Res , vol.67 , pp. 1326-1334
    • Nava-Parada, P.1    Forni, G.2    Knutson, K.L.3    Pease, L.R.4    Celis, E.5
  • 3
    • 2942516628 scopus 로고    scopus 로고
    • Modulating vaccine responses with dendritic cells and Toll-like receptors
    • Pulendran B. Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol Rev 2004; 199:227-250
    • (2004) Immunol Rev , vol.199 , pp. 227-250
    • Pulendran, B.1
  • 4
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: Translating innate to adaptive immunity
    • Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006; 311:17-58.
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 5
    • 20544474210 scopus 로고    scopus 로고
    • Pathogen recognition with Toll-like receptors
    • Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol 2005; 17:338-344
    • (2005) Curr Opin Immunol , vol.17 , pp. 338-344
    • Kawai, T.1    Akira, S.2
  • 6
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007; 7:179-190
    • (2007) Nat Rev Immunol , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 7
    • 21344465240 scopus 로고    scopus 로고
    • TLR signaling and the function of dendritic cells
    • Hemmi H, Akira S. TLR signaling and the function of dendritic cells. Chem Immunol Allergy 2005; 86:120-135
    • (2005) Chem Immunol Allergy , vol.86 , pp. 120-135
    • Hemmi, H.1    Akira, S.2
  • 9
    • 34447505084 scopus 로고    scopus 로고
    • Toll-like receptors and type I interferons
    • Uematsu S, Akira S. Toll-like receptors and type I interferons. J Biol Chem 2007; 282:15319-15323
    • (2007) J Biol Chem , vol.282 , pp. 15319-15323
    • Uematsu, S.1    Akira, S.2
  • 10
    • 0037153191 scopus 로고    scopus 로고
    • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    • Yamamoto M, Sato S, Hemmi H, et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420:324-329
    • (2002) Nature , vol.420 , pp. 324-329
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 11
    • 34548649547 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase in innate immunity
    • Hazeki K, Nigorikawa K, Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull 2007; 30:1617-1623
    • (2007) Biol Pharm Bull , vol.30 , pp. 1617-1623
    • Hazeki, K.1    Nigorikawa, K.2    Hazeki, O.3
  • 12
    • 0036707521 scopus 로고    scopus 로고
    • PI3K-mediated negative feedback regulation of IL-12 production in DCs
    • Fukao T, Tanabe M, Terauchi Y, et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002; 3:875-881
    • (2002) Nat Immunol , vol.3 , pp. 875-881
    • Fukao, T.1    Tanabe, M.2    Terauchi, Y.3
  • 13
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 14
    • 33646697743 scopus 로고    scopus 로고
    • Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
    • Wille-Reece U, Flynn BJ, Lore K, et al. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med 2006; 203:1249-1258
    • (2006) J Exp Med , vol.203 , pp. 1249-1258
    • Wille-Reece, U.1    Flynn, B.J.2    Lore, K.3
  • 15
    • 0242580118 scopus 로고    scopus 로고
    • Cutting edge: Different Tolllike receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-fos
    • Agrawal S, Agrawal A, Doughty B, et al. Cutting edge: different Tolllike receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen- activated protein kinase and c-fos. J Immunol 2003; 171:4984-4989
    • (2003) J Immunol , vol.171 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3
  • 16
    • 0033616482 scopus 로고    scopus 로고
    • Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial
    • Vermorken JB, Claessen AM, van Tinteren H, et al. Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. Lancet 1999; 353:345-350
    • (1999) Lancet , vol.353 , pp. 345-350
    • Vermorken, J.B.1    Claessen, A.M.2    Van Tinteren, H.3
  • 17
    • 3142690381 scopus 로고    scopus 로고
    • Taking a Toll on human disease: Toll-like receptor agonists as vaccine adjuvants and monotherapeutic agents
    • Baldridge JR, McGowan P, Evans JT, et al. Taking a Toll on human disease: Toll-like receptor agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther 2004; 7:1129-1138
    • (2004) Expert Opin Biol Ther , vol.7 , pp. 1129-1138
    • Baldridge, J.R.1    McGowan, P.2    Evans, J.T.3
  • 18
    • 33748683549 scopus 로고    scopus 로고
    • Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma
    • Link BK, Ballas ZK, Weisdorf D, et al. Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. J Immunother 2006; 29:558-568
    • (2006) J Immunother , vol.29 , pp. 558-568
    • Link, B.K.1    Ballas, Z.K.2    Weisdorf, D.3
  • 19
    • 23944489407 scopus 로고    scopus 로고
    • Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    • Napolitani G, Rinaldi A, Bertoni F, Sallustro F, Lanzavecchia, A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005; 6:769-776
    • (2005) Nat Immunol , vol.6 , pp. 769-776
    • Napolitani, G.1    Rinaldi, A.2    Bertoni, F.3    Sallustro, F.4    Lanzavecchia, A.5
  • 20
    • 23644449245 scopus 로고    scopus 로고
    • The expression of Tolllike receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, Joosten LAB, Abdollahi-Roodsaz S. The expression of Tolllike receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005; 52:2313-2322
    • (2005) Arthritis Rheum , Issue.52 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.B.2    Abdollahi-Roodsaz, S.3
  • 21
    • 33745945647 scopus 로고    scopus 로고
    • Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses
    • Warger T, Osterloh P, Rechtsteiner G, et al. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses. Blood 2006; 108:544-550
    • (2006) Blood , vol.108 , pp. 544-550
    • Warger, T.1    Osterloh, P.2    Rechtsteiner, G.3
  • 22
    • 21044458122 scopus 로고    scopus 로고
    • - dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    • - dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol 2005; 174:6592-6597
    • (2005) J Immunol , vol.174 , pp. 6592-6597
    • Naik, S.H.1    Proietto, A.I.2    Wilson, N.S.3
  • 23
    • 38849141667 scopus 로고    scopus 로고
    • Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking
    • Xu Y, Zhan Y, Lew AM, Naik SH, Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol 2007; 179: 7577-7584
    • (2007) J Immunol , vol.179 , pp. 7577-7584
    • Xu, Y.1    Zhan, Y.2    Lew, A.M.3    Naik, S.H.4    Kershaw, M.H.5
  • 24
    • 0036534871 scopus 로고    scopus 로고
    • The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    • Gilliet M, Boonstra A, Paturel C, et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med 2002; 195:953-958
    • (2002) J Exp Med , vol.195 , pp. 953-958
    • Gilliet, M.1    Boonstra, A.2    Paturel, C.3
  • 25
    • 0034332450 scopus 로고    scopus 로고
    • Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
    • Brasel K, De Smedt T, Smith JL, Maliszewski CR. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood 2000; 96:3029-3039
    • (2000) Blood , vol.96 , pp. 3029-3039
    • Brasel, K.1    De Smedt, T.2    Smith, J.L.3    Maliszewski, C.R.4
  • 26
    • 35549000134 scopus 로고    scopus 로고
    • Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    • Naik SH, Sathe P, Park H-Y, et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 2007; 8:1217-1226
    • (2007) Nat Immunol , vol.8 , pp. 1217-1226
    • Naik, S.H.1    Sathe, P.2    Park, H.-Y.3
  • 27
    • 0037114134 scopus 로고    scopus 로고
    • Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    • Brawand P, Fitzpatrick DR, Greenfield BW, Brasel K, Maliszewski CR, De Smedt T. Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs. J Immunol 2002; 169:6711-6719
    • (2002) J Immunol , vol.169 , pp. 6711-6719
    • Brawand, P.1    Fitzpatrick, D.R.2    Greenfield, B.W.3    Brasel, K.4    Maliszewski, C.R.5    De Smedt, T.6
  • 29
    • 38549141910 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells
    • Vanhoutte F, Paget C, Breuilh L, et al. Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells. Immunol Lett 2008; 116:86-94.
    • (2008) Immunol Lett , vol.116 , pp. 86-94
    • Vanhoutte, F.1    Paget, C.2    Breuilh, L.3
  • 30
    • 65249164025 scopus 로고    scopus 로고
    • Multiple signalling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    • Mäkelä SM, Strengell M, Pietilä TE, Osterland P, Julkunen I. Multiple signalling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells. J Leuk Biol 2009; 85:664-672
    • (2009) J Leuk Biol , vol.85 , pp. 664-672
    • Mäkelä, S.M.1    Strengell, M.2    Pietilä, T.E.3    Osterland, P.4    Julkunen, I.5
  • 31
    • 33846207958 scopus 로고    scopus 로고
    • MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists
    • Bagchi A, Herrup EA, Warren HS, et al. MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol 2007; 178:1164-1171
    • (2007) J Immunol , vol.178 , pp. 1164-1171
    • Bagchi, A.1    Herrup, E.A.2    Warren, H.S.3
  • 32
    • 55849138791 scopus 로고    scopus 로고
    • Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
    • Zhu Q, Egelston C, Vivekanandham A, et al. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc Natl Acad Sci USA 2008; 105:16260-16265
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16260-16265
    • Zhu, Q.1    Egelston, C.2    Vivekanandham, A.3
  • 33
    • 0029905555 scopus 로고    scopus 로고
    • Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
    • De Smedt T, Pajak B, Muraille E, et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 1996; 184:1413-1424
    • (1996) J Exp Med , vol.184 , pp. 1413-1424
    • De Smedt, T.1    Pajak, B.2    Muraille, E.3
  • 34
    • 39749103442 scopus 로고    scopus 로고
    • A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands
    • Dowling D, Hamilton CM, O'Neill SM. A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands. Cytokine 2008; 41:254-262
    • (2008) Cytokine , vol.41 , pp. 254-262
    • Dowling, D.1    Hamilton, C.M.2    O'Neill, S.M.3
  • 35
    • 41849101964 scopus 로고    scopus 로고
    • Selective synergy in anti-inflammatory cytokine production upon cooperated signalling via TLR4 and TLR2 in murine conventional dendritic cells
    • Hirata N, Yanagawa Y, Ebihara T, et al. Selective synergy in anti-inflammatory cytokine production upon cooperated signalling via TLR4 and TLR2 in murine conventional dendritic cells. Mol Immunol 2008; 45:2734-2742
    • (2008) Mol Immunol , vol.45 , pp. 2734-2742
    • Hirata, N.1    Yanagawa, Y.2    Ebihara, T.3
  • 36
    • 61449262031 scopus 로고    scopus 로고
    • Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells
    • Dearman RJ, Cumberbatch M, Maxwell G, Basketter DA, Kimber I. Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology 2008; 126:475-484
    • (2008) Immunology , vol.126 , pp. 475-484
    • Dearman, R.J.1    Cumberbatch, M.2    Maxwell, G.3    Basketter, D.A.4    Kimber, I.5
  • 37
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H, Kaisho K, Takeda K, Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 2003; 170:3059-3064
    • (2003) J Immunol , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, K.2    Takeda, K.3    Akira, S.4
  • 38
    • 33645841633 scopus 로고    scopus 로고
    • IkB kinase-A is critical for interferon-α production induced by Toll-like receptors 7 and 9
    • Hoshino K, Sugiyama T, Matsumoto M, et al. IkB kinase-α is critical for interferon-a production induced by Toll-like receptors 7 and 9. Nature 2006; 440:949-953
    • (2006) Nature , vol.440 , pp. 949-953
    • Hoshino, K.1    Sugiyama, T.2    Matsumoto, M.3
  • 39
    • 18644364701 scopus 로고    scopus 로고
    • A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin- 12p70 secretion by dendritic cells
    • Gautier G, Humbert M, Deauvieau F, et al. A type I interferon autocrine- paracrine loop is involved in Toll-like receptor-induced interleukin- 12p70 secretion by dendritic cells. J Exp Med 2005; 201:1435-1446
    • (2005) J Exp Med , vol.201 , pp. 1435-1446
    • Gautier, G.1    Humbert, M.2    Deauvieau, F.3
  • 40
    • 35648991998 scopus 로고    scopus 로고
    • Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses
    • Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J. Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses. Cell Immunol 2007; 247:72-84.
    • (2007) Cell Immunol , vol.247 , pp. 72-84
    • Bohnenkamp, H.R.1    Papazisis, K.T.2    Burchell, J.M.3    Taylor-Papadimitriou, J.4
  • 42
    • 1842477227 scopus 로고    scopus 로고
    • A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signalrelated kinase mitogen-activated protein kinase and c-fos in dendritic cells
    • Dillon S, Agrawal A, Van Dyke T, et al. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signalrelated kinase mitogen-activated protein kinase and c-fos in dendritic cells. J Immunol 2004; 172:4733-4743
    • (2004) J Immunol , vol.172 , pp. 4733-4743
    • Dillon, S.1    Agrawal, A.2    Van Dyke, T.3
  • 43
    • 1342324768 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    • Redecke V, Häcker H, Datta SK, et al. Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 2004; 172:2739-2743
    • (2004) J Immunol , vol.172 , pp. 2739-2743
    • Redecke, V.1    Häcker, H.2    Datta, S.K.3
  • 44
    • 2442652766 scopus 로고    scopus 로고
    • Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response
    • Didierlaurent A, Ferrero I, Otten LA, et al. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol 2004; 172:6922-6930
    • (2004) J Immunol , vol.172 , pp. 6922-6930
    • Didierlaurent, A.1    Ferrero, I.2    Otten, L.A.3
  • 45
    • 34248148098 scopus 로고    scopus 로고
    • Enhanced IL-10 production by TLR4- and TLR2- primed dendritic cells upon TLR restimulation
    • Yanagawa Y, Onoé K. Enhanced IL-10 production by TLR4- and TLR2- primed dendritic cells upon TLR restimulation. J Immunol 2007; 178: 6173-6180
    • (2007) J Immunol , vol.178 , pp. 6173-6180
    • Yanagawa, Y.1    Onoé, K.2
  • 46
    • 44749088349 scopus 로고    scopus 로고
    • Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics
    • Jarnicki AG, Conroy H, Brereton C, et al. Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J Immunol 2008; 180:3797-3806
    • (2008) J Immunol , vol.180 , pp. 3797-3806
    • Jarnicki, A.G.1    Conroy, H.2    Brereton, C.3
  • 47
    • 33749355639 scopus 로고    scopus 로고
    • TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation
    • Qian C, Jiang X, An H, et al. TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood 2006; 108:2307-2315
    • (2006) Blood , vol.108 , pp. 2307-2315
    • Qian, C.1    Jiang, X.2    An, H.3
  • 48
    • 0141862079 scopus 로고    scopus 로고
    • Differential role of mitogen- activated protein kinases in CD40-mediated Il-12 production by immature and mature dendritic cells
    • Kikuchi Y, Yanagawa Y, Iwabuchi K, Onoé K. Differential role of mitogen- activated protein kinases in CD40-mediated Il-12 production by immature and mature dendritic cells. Immunol Lett 2003; 89:149-154
    • (2003) Immunol Lett , vol.89 , pp. 149-154
    • Kikuchi, Y.1    Yanagawa, Y.2    Iwabuchi, K.3    Onoé, K.4
  • 49
    • 0032497832 scopus 로고    scopus 로고
    • Structure and function of phosphoinositide 3-kinases
    • Wymann MP, Pirola L. Structure and function of phosphoinositide 3- kinases. Biochim Biophys Acta 1998; 1436:127-150
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 127-150
    • Wymann, M.P.1    Pirola, L.2
  • 50
    • 66949179759 scopus 로고    scopus 로고
    • PI3K p110b positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role
    • Utsugi M, Dobashi K, Ono A, et al. PI3K p110b positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role. J Immunol 2009; 182: 5225-5231
    • (2009) J Immunol , vol.182 , pp. 5225-5231
    • Utsugi, M.1    Dobashi, K.2    Ono, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.