Combination of improved 18o incorporation and multiple reaction monitoring: A universal strategy for absolute quantitative verification of serum candidate biomarkers of liver cancer

Journal of Proteome Research

Volumn 9, Issue 6, 2010, Pages 3319-3327

  Zhao, Yan ^a   Jia, Wei ^a   Sun, Wei ^a   Jin, Wenhai ^b   Guo, Lihai ^b   Wei, Junying ^a   Ying, Wantao ^a   Zhang, Yangjun ^a   Xie, Yongming ^b   Jiang, Ying ^a   He, Fuchu ^a   Qian, Xiaohong ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b MDS SCIEX   (Canada)

Author keywords

18O Labeling; Absolute quantification; Biomarker verification; Clusterin; Liver cancer; MRM; Serum; Vitronectin

Indexed keywords

CLUSTERIN; IODOACETAMIDE; OXYGEN; OXYGEN 18; RECOMBINANT PROTEIN; TRIS(2 CARBOXYETHYL)PHOSPHINE; TRYPSIN; VITRONECTIN; CLU PROTEIN, HUMAN; TUMOR MARKER;

ACCURACY; ARTICLE; CAPILLARY; CHEMICAL MODIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LABELING INDEX; LIVER CANCER; LIVER CELL CARCINOMA; MASS SPECTROMETRY; MICROWAVE COOKING; MONITORING; PARAMETER; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN STABILITY; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RELIABILITY; SEPARATION TECHNIQUE; STANDARD; VALIDATION PROCESS; AMINO ACID SEQUENCE; BLOOD; CHEMISTRY; ISOTOPE LABELING; LIVER TUMOR; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLUSTERIN; HUMANS; ISOTOPE LABELING; LINEAR MODELS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; OXYGEN ISOTOPES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR MARKERS, BIOLOGICAL; VITRONECTIN;

EID: 77954573328     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr9011969     Document Type: Article

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