메뉴 건너뛰기




Volumn 220, Issue 2, 2010, Pages 290-296

Network-based drugs and biomarkers

Author keywords

Biomarker; Drug; Gene; Network; Signalling; Systems biology; Treatment

Indexed keywords

BIOLOGICAL MARKER; STRESS ACTIVATED PROTEIN KINASE;

EID: 73949157882     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2646     Document Type: Review
Times cited : (64)

References (47)
  • 2
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 3
    • 33644524918 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics turns quantitative
    • Ong SE, Mann M. Mass spectrometry-based proteomics turns quantitative. Nat Chem Biol 2005;1:252-262.
    • (2005) Nat Chem Biol , vol.1 , pp. 252-262
    • Ong, S.E.1    Mann, M.2
  • 4
    • 44249108848 scopus 로고    scopus 로고
    • Directional and quantitative phosphorylation networks
    • Jørgensen C, Linding R. Directional and quantitative phosphorylation networks. Brief Funct Genom Proteom 2008;7:17-26.
    • (2008) Brief Funct Genom Proteom , vol.7 , pp. 17-26
    • Jørgensen, C.1    Linding, R.2
  • 5
    • 34547623194 scopus 로고    scopus 로고
    • Common effector processing mediates cell-specific responses to stimuli
    • Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature 2007;448:604-608.
    • (2007) Nature , vol.448 , pp. 604-608
    • Miller-Jensen, K.1    Janes, K.A.2    Brugge, J.S.3    Lauffenburger, D.A.4
  • 6
    • 66249136447 scopus 로고    scopus 로고
    • Nongenetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Nongenetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009;459:428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 7
    • 28844441230 scopus 로고    scopus 로고
    • A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    • Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 2005;310: 1646-1653.
    • (2005) Science , vol.310 , pp. 1646-1653
    • Janes, K.A.1    Albeck, J.G.2    Gaudet, S.3    Sorger, P.K.4    Lauffenburger, D.A.5    Yaffe, M.B.6
  • 8
    • 33750351769 scopus 로고    scopus 로고
    • Data-driven modelling of signal-transduction networks
    • Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol 2006;7:820-828.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 820-828
    • Janes, K.A.1    Yaffe, M.B.2
  • 12
    • 54249117296 scopus 로고    scopus 로고
    • Phosphorylation networks regulating JNK activity in diverse genetic backgrounds
    • Bakal C, Linding R, Llense F, Heffern E, Martin-Blanco E, Pawson T, et al. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 2008;322:453-456.
    • (2008) Science , vol.322 , pp. 453-456
    • Bakal, C.1    Linding, R.2    Llense, F.3    Heffern, E.4    Martin-Blanco, E.5    Pawson, T.6
  • 14
    • 65349179556 scopus 로고    scopus 로고
    • Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol 2009;5:e1000340.
    • Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol 2009;5:e1000340.
  • 18
    • 41149167511 scopus 로고    scopus 로고
    • Network Medicine
    • Pawson T, Linding R. Network Medicine. FEBS Lett 2008;582: 1266-1270.
    • (2008) FEBS Lett , vol.582 , pp. 1266-1270
    • Pawson, T.1    Linding, R.2
  • 19
    • 65349149138 scopus 로고    scopus 로고
    • Levy ED, Landry CR, Michnick SW. How perfect can protein interactomes be? Sci Signal 2009;2:pe11.
    • Levy ED, Landry CR, Michnick SW. How perfect can protein interactomes be? Sci Signal 2009;2:pe11.
  • 20
    • 34250882643 scopus 로고    scopus 로고
    • Quantitative morphological signatures define local signaling networks regulating cell morphology
    • Bakal C, Aach J, Church G, Perrimon N. Quantitative morphological signatures define local signaling networks regulating cell morphology. Science 2007;316:1753-1756.
    • (2007) Science , vol.316 , pp. 1753-1756
    • Bakal, C.1    Aach, J.2    Church, G.3    Perrimon, N.4
  • 21
    • 34250722602 scopus 로고    scopus 로고
    • Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
    • Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci USA 2007;104:5860-5865.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5860-5865
    • Wolf-Yadlin, A.1    Hautaniemi, S.2    Lauffenburger, D.A.3    White, F.M.4
  • 23
    • 69849115198 scopus 로고    scopus 로고
    • Therapeutically targeting ErbB3: A key node in ligandinduced activation of the ErbB receptor-PI3K axis
    • Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, et al. Therapeutically targeting ErbB3: a key node in ligandinduced activation of the ErbB receptor-PI3K axis. Sci Signal 2009;2:ra31.
    • (2009) Sci Signal , vol.2
    • Schoeberl, B.1    Pace, E.A.2    Fitzgerald, J.B.3    Harms, B.D.4    Xu, L.5    Nie, L.6
  • 26
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. Drug target identification using side-effect similarity. Science 2008;321: 263-266.
    • (2008) Science , vol.321 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.C.3    Jensen, L.J.4    Bork, P.5
  • 27
    • 41649119247 scopus 로고    scopus 로고
    • Protein networks in disease
    • Ideker T, Sharan R. Protein networks in disease. Genome Res 2008;18:644-652.
    • (2008) Genome Res , vol.18 , pp. 644-652
    • Ideker, T.1    Sharan, R.2
  • 29
    • 68849117407 scopus 로고    scopus 로고
    • Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
    • Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Mol Cancer Ther 2009;8:2183-2192.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2183-2192
    • Pritchard, J.R.1    Cosgrove, B.D.2    Hemann, M.T.3    Griffith, L.G.4    Wands, J.R.5    Lauffenburger, D.A.6
  • 30
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006;12:895-904.
    • (2006) Nat Med , vol.12 , pp. 895-904
    • Steeg, P.S.1
  • 31
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006;127:679-695.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 32
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 33
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metast Rev 1989;8:98-101.
    • (1989) Cancer Metast Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 34
    • 58849126879 scopus 로고    scopus 로고
    • Three-dimensional context regulation of metastasis
    • Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metast 2009;26:35-49.
    • (2009) Clin Exp Metast , vol.26 , pp. 35-49
    • Erler, J.T.1    Weaver, V.M.2
  • 35
    • 58949092790 scopus 로고    scopus 로고
    • The tumor microenvironment and metastatic disease
    • Lunt SJ, Chaudary N, Hill RP. The tumor microenvironment and metastatic disease. Clin Exp Metast 2009;26:19-34.
    • (2009) Clin Exp Metast , vol.26 , pp. 19-34
    • Lunt, S.J.1    Chaudary, N.2    Hill, R.P.3
  • 36
    • 0141988559 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor invasion and metastasis: An integrated view
    • Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 2003;3:659-671.
    • (2003) Curr Mol Med , vol.3 , pp. 659-671
    • Cairns, R.A.1    Khokha, R.2    Hill, R.P.3
  • 38
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009;15:35-44.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6
  • 39
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • in press
    • WeigeltB, LoAT, ParkCC, GrayJW, BissellMJ. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat 2009;(in press).
    • (2009) Breast Cancer Res Treat
    • WeigeltB1    LoAT2    ParkCC3    GrayJW4    BissellMJ5
  • 40
    • 34248650697 scopus 로고    scopus 로고
    • The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    • Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007;1:84-96.
    • (2007) Mol Oncol , vol.1 , pp. 84-96
    • Kenny, P.A.1    Lee, G.Y.2    Myers, C.A.3    Neve, R.M.4    Semeiks, J.R.5    Spellman, P.T.6
  • 41
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003;3:921-930.
    • (2003) Nat Rev Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 42
    • 62449314690 scopus 로고    scopus 로고
    • Dynamic imaging of cancer invasion and metastasis: Principles and preclinical applications
    • Friedl P. Dynamic imaging of cancer invasion and metastasis: principles and preclinical applications. Clin Exp Metast 2009;26:269-271.
    • (2009) Clin Exp Metast , vol.26 , pp. 269-271
    • Friedl, P.1
  • 43
    • 34648832906 scopus 로고    scopus 로고
    • Illuminating the metastatic process
    • Sahai E. Illuminating the metastatic process. Nat Rev Cancer 2007;7:737-749.
    • (2007) Nat Rev Cancer , vol.7 , pp. 737-749
    • Sahai, E.1
  • 44
    • 57749115814 scopus 로고    scopus 로고
    • The role of molecular analysis in breast cancer
    • Geyer FC, Marchio C, Reis-Filho JS. The role of molecular analysis in breast cancer. Pathology 2009;41:77-88.
    • (2009) Pathology , vol.41 , pp. 77-88
    • Geyer, F.C.1    Marchio, C.2    Reis-Filho, J.S.3
  • 45
    • 34547146985 scopus 로고    scopus 로고
    • Network medicine - from obesity to the 'diseasome'
    • Barabási AL. Network medicine - from obesity to the 'diseasome'. N Engl J Med 2007;357:404-407.
    • (2007) N Engl J Med , vol.357 , pp. 404-407
    • Barabási, A.L.1
  • 47
    • 53649095010 scopus 로고    scopus 로고
    • A network solution
    • Henney A, Superti-Furga G. A network solution. Nature 2008; 455:730-731.
    • (2008) Nature , vol.455 , pp. 730-731
    • Henney, A.1    Superti-Furga, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.