High-yield peptide-extraction method for the discovery of subnanomolar biomarkers from small serum samples

Journal of Proteome Research

Volumn 9, Issue 4, 2010, Pages 1694-1705

  Kawashima, Yusuke ^a   Fukutomi, Toshiyuki ^a   Tomonaga, Takeshi ^a,b   Takahashi, Hiroki ^a   Nomura, Fumio ^a,b   Maeda, Tadakazu ^a,c   Kodera, Yoshio ^a,b,c  

^a KITASATO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Biomarkers; Colorectal cancer; Mass spectrometry; Peptide extraction; Peptidomics; Plasma; Serum

Indexed keywords

ALBUMIN; IMMUNOGLOBULIN G; LOW MOLECULAR WEIGHT PROTEIN; NUCLEAR PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; ZYXIN;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL FEATURE; COLON CANCER; DIFFERENTIAL SOLUBILIZATION; EXTRACTION; FEMALE; HUMAN; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLUBILIZATION; ULTRAFILTRATION;

ADULT; AGED; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORECTAL NEOPLASMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; PEPTIDE MAPPING; PEPTIDES; REPRODUCIBILITY OF RESULTS; SAMPLE SIZE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 77950642135     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr9008018     Document Type: Article

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