Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer

Analytical Chemistry

Volumn 81, Issue 9, 2009, Pages 3462-3470

  DeSouza, Leroi V ^a   Romaschin, Alexander D ^b,c   Colgan, Terence J ^c,d   Siu, K W Michael ^a  

^a YORK UNIVERSITY   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE QUANTIFICATION; AVERAGE CONCENTRATION; BIO-MARKER DISCOVERY; CANCER MARKERS; CONTROL SAMPLES; DIFFERENTIAL EXPRESSIONS; ENDOMETRIAL CANCER; ENDOMETRIAL CARCINOMA; IMMUNOGLOBULIN RECEPTORS; ION TRAPS; ISOTOPE DILUTION MASS SPECTROMETRY; MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY; MULTIPLE REACTION MONITORING; PROTEOME; PYRUVATE KINASE; QUADRUPOLE/TIME OF FLIGHTS; RANGE COMPRESSION; SOLUBLE FRACTION; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATES; TOTAL PROTEIN;

AMINES; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PEPTIDES; SPECTRUM ANALYSIS;

BIOMARKERS;

PYRUVATE KINASE; SECRETORY COMPONENT; TUMOR MARKER;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENDOMETRIUM CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRID TRIPLE QUADRUPOLE LINEAR ION TRAP TANDEM MASS SPECTROMETRY; MULTIPLE REACTION MONITORING; PEPTIDE ANALYSIS; QUANTITATIVE DIAGNOSIS; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATE; VALIDATION PROCESS;

ENDOMETRIUM; FEASIBILITY STUDIES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PYRUVATE KINASE; RECEPTORS, POLYMERIC IMMUNOGLOBULIN; STOMACH NEOPLASMS; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL;

EID: 66149136449     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac802726a     Document Type: Article

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