Mitochondrial DNA metabolism targeting drugs

Advanced Drug Delivery Reviews

Volumn 49, Issue 1-2, 2001, Pages 175-187

  Rowe, Thomas C ^a   Weissig, Volkmar ^b   Lawrence, Jeffrey W ^c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Dideoxynucleoside; Inhibitor; Intercalator; Lipophilic; Mitochondria; Polyamine; Polymerase; Replication; Topoisomerase; Viral

Indexed keywords

CELLS; DNA; METABOLISM; POSITIVE IONS;

TOPOISOMERASE;

DRUG THERAPY;

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; ANTIINFECTIVE AGENT; CIPROFLOXACIN; CYTOCHROME C OXIDASE; DEQUALINIUM; DIDANOSINE; DIETHYLSPERMINE; DITERCALINIUM; DNA; DNA DIRECTED DNA POLYMERASE ALPHA; DNA TOPOISOMERASE; ENZYME INHIBITOR; ETHIDIUM BROMIDE; FIALURIDINE; MITOGUAZONE; N1,N6 BIS(ETHYL)SPERMIDINE; NALIDIXIC ACID; PENTAMIDINE; POLYAMINE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

BONE MARROW TOXICITY; DNA METABOLISM; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HEPATITIS; HUMAN; INTERCALATION COMPLEX; LACTIC ACIDOSIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MYOPATHY; NEUROPATHY; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; REVIEW;

EID: 0035797128     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00133-8     Document Type: Article

References (75)

1. Mitochondrial diseases in man and mouse
2. Mitochondrial disorders: Clinical and genetic features
3. Mitochondrial medicine
4. Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity
5. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
6. Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway
7. Mitochondrial toxicity of antiviral drugs
8. Reversible tenfold reduction in mitochondria DNA content of human cells treated with ethidium bromide
9. Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent
10. Analysis of methylglyoxal bis(guanylhydrazone)-induced alterations of hamster tumor mitochondria by correlated studies of selective rhodamine binding, ultrastructural damage, DNA replication, and reversibility
11. Synthetic polyamine analogues as antineoplastics
12. Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function
13. Anti-mitochondrial effects of bisethyl polyamines in mammalian cells
14. 4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells
15. Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077
16. Dequalinium induces a selective depletion of mitochondrial DNA from HeLa human cervical carcinoma cells
17. The content of intracellular mitochondrial DNA is decreased by 1-methyl-4-phenylpyridinium ion (MPP+)
18. The mitochondrial genome: Structure, transcription, translation and replication
19. Replication and transcription of vertebrate mitochondrial DNA
20. Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phopholipids in the tissues of the rat
21. Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event
22. Isolation of human cell lines lacking mitochondrial DNA
23. Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
24. Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity
25. Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production
26. Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2′-deoxy-2′-fluoro-1-beta-d-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity
27. DNA topoisomerases
28. Eukaryotic DNA topoisomerase IIβ
29. DNA topoisomerase poisons as antitumor drugs
30. DNA topoisomerases: Essential enzymes and lethal targets
31. Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
32. DNA gyrase, topoisomerase IV, and the 4-quinolones
33. DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities
34. DNA gyrase as a drug target
35. Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents
36. Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells
37. The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria
38. DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26
39. Modulation of gyrase-mediated DNA cleavage and cell killing by ATP
40. DNA topoisomerases: A new twist for antiparasitic chemotherapy?
41. Localization of a type II DNA topoisomerase to two sites at the periphery of the kinetoplast DNA of Crithidia fasciculata
42. Novobiocin affinity purification of a mitochondrial type II topoisomerase from the trypanosomatid Crithidia fasciculata
43. Cloning and characterization of the gene encoding a mitochondrially localized DNA topoisomerase II in Dictyostelium discoideum: Western blot analysis
44. Chemotherapy of trypanosomiasis
45. Ethidium and propidium
46. Abnormal DNA patterns in animal mitochondria: Ethidium bromide-induced breakdown of closed circular DNA and conditions leading to oligomer accumulation
47. The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in Hela cells
48. DNA modification and cancer
49. Structural and sequence-dependent aspects of drug intercalation into nucleic acids
50. Removal of DNA curving by DNA ligands: Gel electrophoresis study
51. Intrinsically bent DNA flanks both sides of an RNA polymerase I transcription start site. Both regions display novel electrophoretic mobility
52. Linking numbers and nucleosomes
53. Membrane potential and surface potential in mitochondria: Uptake and binding of lipophilic cations
54. Mitochondrial DNA maintenance in vertebrates
55. DNA biosynthesis in mitochondria. Differential inhibition of mitochondrial and nuclear DNA polymerases by the mutagenic dyes ethidium bromide and acriflavin
56. Selective alteration of mitochondrial function by ditercalinium (NSC 335153), a DNA bisintercalating agent
57. Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage
58. The noncovalent complex between DNA and the bifunctional intercalator ditercalinium is a substrate for the UVrABC endonuclease of Escherichia coli
59. Induction of an abortive and futile DNA repair process in E. coli by the antitumor DNA bifunctional intercalator, ditercalinium: Role in polA in death induction
60. Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II
61. Polyamines as targets for therapeutic intervention
62. Synthetic DNA minor groove-binding drugs
63. DNA multimode interaction with berenil and pentamidine; double helix stiffening, unbending and bending
64. The effects of methylglyoxal-bis(guanylhydrazone) on spermine binding and transport in liver mitochondria
65. Pentamidine: A review
66. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs
67. Selective targeting of bioactive compounds to mitochondria
68. Mitochondrial membrane potential in living cells
69. Photoactivation enhances the mitochondrial toxicity of the cationic rhodacyanine MKT-077
70. Selective antimitochondrial agents inhibit calmodulin
71. Inhibition of rodent protein kinase C by the anticarcinoma agent dequalinium
72. Inhibition of the bovine-heart mitochondrial F1-ATPase by cationic dyes and amphipathic peptides
73. Inhibition and photoinactivation of the bovine heart mitochondrial F1-ATPase by the cytotoxic agent, dequalinium
74. In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function
75. The d-loo structure of human mtDNA is destabilized directly by 1-methyl-4-phenylpyridinium ion (MPP+), a parkinsonism-causing toxin