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Volumn 77, Issue 6, 2010, Pages 489-496

Diverse functions of hedgehog signaling in formation and physiology of steroidogenic organs

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; STEROIDOGENIC FACTOR 1; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3;

EID: 77954477962     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.21174     Document Type: Review
Times cited : (27)

References (71)
  • 1
    • 77749246519 scopus 로고    scopus 로고
    • Fetal Leydig cells: Progenitor cell maintenance and differentiation
    • Barsoum IB, Yao HH. 2009. Fetal Leydig cells: Progenitor cell maintenance and differentiation. J Androl 31:11-15.
    • (2009) J Androl , vol.31 , pp. 11-15
    • Barsoum, I.B.1    Yao, H.H.2
  • 2
    • 64049103389 scopus 로고    scopus 로고
    • Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism
    • Barsoum IB, Bingham NC, Parker KL, Jorgensen JS, Yao HH. 2009. Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism. Dev Biol 329:96-103.
    • (2009) Dev Biol , vol.329 , pp. 96-103
    • Barsoum, I.B.1    Bingham, N.C.2    Parker, K.L.3    Jorgensen, J.S.4    Yao, H.H.5
  • 3
    • 0018954889 scopus 로고
    • Proliferative activity and cell migration in the adrenal cortex of fetal and neonatal rats: An autoradiographic study
    • Bertholet JY. 1980. Proliferative activity and cell migration in the adrenal cortex of fetal and neonatal rats: An autoradiographic study. J Endocrinol 87:1-9.
    • (1980) J Endocrinol , vol.87 , pp. 1-9
    • Bertholet, J.Y.1
  • 5
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood MJ, McMahon AP. 1995. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138.
    • (1995) Dev Biol , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 6
    • 0030111258 scopus 로고    scopus 로고
    • Sertoli cell signaling by Desert hedgehog regulates the male germline
    • DOI 10.1016/S0960-9822(02)00480-3
    • Bitgood MJ, Shen L, McMahon AP. 1996. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 6: 298-304. (Pubitemid 3035912)
    • (1996) Current Biology , vol.6 , Issue.3 , pp. 298-304
    • Bitgood, M.J.1    Shen, L.2    McMahon, A.P.3
  • 7
    • 0036566575 scopus 로고    scopus 로고
    • Pallister-Hall syndrome phenotype in mice mutant for Gli3
    • Bose J, Grotewold L, Ruther U. 2002. Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet 11: 1129-1135. (Pubitemid 34521093)
    • (2002) Human Molecular Genetics , vol.11 , Issue.9 , pp. 1129-1135
    • Bose, J.1    Grotewold, L.2    Ruther, U.3
  • 8
    • 0345700294 scopus 로고    scopus 로고
    • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad
    • Brennan J, Tilmann C, Capel B. 2003. Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev 17:800-810.
    • (2003) Genes Dev , vol.17 , pp. 800-810
    • Brennan, J.1    Tilmann, C.2    Capel, B.3
  • 9
    • 58149473438 scopus 로고    scopus 로고
    • Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis
    • Brokken LJ, Adamsson A, Paranko J, Toppari J. 2009. Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Endocrinology 150:445-451.
    • (2009) Endocrinology , vol.150 , pp. 445-451
    • Brokken, L.J.1    Adamsson, A.2    Paranko, J.3    Toppari, J.4
  • 10
    • 4544336208 scopus 로고    scopus 로고
    • Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis
    • Canto P, Soderlund D, Reyes E, Mendez JP. 2004. Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis. J Clin Endocrinol Metab 89: 4480-4483.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4480-4483
    • Canto, P.1    Soderlund, D.2    Reyes, E.3    Mendez, J.P.4
  • 11
    • 32144444310 scopus 로고    scopus 로고
    • A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis
    • Canto P, Vilchis F, Soderlund D, Reyes E, Mendez JP. 2005. A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis. Mol Hum Reprod 11:833-836.
    • (2005) Mol Hum Reprod , vol.11 , pp. 833-836
    • Canto, P.1    Vilchis, F.2    Soderlund, D.3    Reyes, E.4    Mendez, J.P.5
  • 13
    • 34548170996 scopus 로고    scopus 로고
    • The sonic hedgehog signaling network in development and neoplasia
    • Chari NS, McDonnell TJ. 2007. The sonic hedgehog signaling network in development and neoplasia. Adv Anat Pathol 14: 344-352.
    • (2007) Adv Anat Pathol , vol.14 , pp. 344-352
    • Chari, N.S.1    McDonnell, T.J.2
  • 14
    • 33751337806 scopus 로고    scopus 로고
    • Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis
    • Chen X, Horiuchi A, Kikuchi N, Osada R, Yoshida J, Shiozawa T, Konishi I. 2007. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis. Cancer Sci 98:68-76.
    • (2007) Cancer Sci , vol.98 , pp. 68-76
    • Chen, X.1    Horiuchi, A.2    Kikuchi, N.3    Osada, R.4    Yoshida, J.5    Shiozawa, T.6    Konishi, I.7
  • 15
    • 70350578581 scopus 로고    scopus 로고
    • Targeted disruption of sonic hedgehog in the mouse adrenal leads to adrenocortical hypoplasia
    • Ching S, Vilain E. 2009. Targeted disruption of sonic hedgehog in the mouse adrenal leads to adrenocortical hypoplasia. Genesis 47:628-637.
    • (2009) Genesis , vol.47 , pp. 628-637
    • Ching, S.1    Vilain, E.2
  • 16
    • 0033709190 scopus 로고    scopus 로고
    • Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules
    • Clark AM, Garland KK, Russell LD. 2000. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod 63: 1825-1838.
    • (2000) Biol Reprod , vol.63 , pp. 1825-1838
    • Clark, A.M.1    Garland, K.K.2    Russell, L.D.3
  • 17
    • 0019169705 scopus 로고
    • Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus, and postaxial polydactyly - A new syndrome? Part II: Neuropathological considerations
    • DOI 10.1002/ajmg.1320070111
    • Clarren SK, Alvord EC, Jr., Hall JG. 1980. Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate a.u., and postaxial polydactyly - A new syndrome? Part II: Neuropathological considerations. Am J Med Genet 7:75-83. (Pubitemid 11225709)
    • (1980) American Journal of Medical Genetics , vol.7 , Issue.1 , pp. 75-83
    • Clarren, S.K.1    Alvord Jr., E.C.2    Hall, J.G.3
  • 18
    • 4544227743 scopus 로고    scopus 로고
    • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice
    • Cambridge, England
    • Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE. 2004. Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development (Cambridge, England) 131: 4095-4105.
    • (2004) Development , vol.131 , pp. 4095-4105
    • Cui, S.1    Ross, A.2    Stallings, N.3    Parker, K.L.4    Capel, B.5    Quaggin, S.E.6
  • 20
    • 0001159182 scopus 로고
    • Cell proliferation and displacement in the adrenal cortex of young rats injected with tritiated thymidine
    • Ford JK, Young RW. 1963. Cell proliferation and displacement in the adrenal cortex of young rats injected with tritiated thymidine. Anat Rec 146:125-137.
    • (1963) Anat Rec , vol.146 , pp. 125-137
    • Ford, J.K.1    Young, R.W.2
  • 21
    • 0030922218 scopus 로고    scopus 로고
    • The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo
    • Giuili G, Shen WH, Ingraham HA. 1997. The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo. Development (Cambridge, England) 124: 1799-1807. (Pubitemid 27248346)
    • (1997) Development , vol.124 , Issue.9 , pp. 1799-1807
    • Giuili, G.1    Shen, W.-H.2    Ingraham, H.A.3
  • 22
    • 0019210894 scopus 로고
    • Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate a.u. and postaxial polydactyly - A new syndrome? Part I: Clinical, causal, and pathogenetic considerations
    • Hall JG, Pallister PD, Clarren SK, Beckwith JB, Wiglesworth FW, Fraser FC, Cho S, Benke PJ, Reed SD. 1980. Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate a.u. and postaxial polydactyly - A new syndrome? Part I: Clinical, causal, and pathogenetic considerations. Am J Med Genet 7: 47-74.
    • (1980) Am J Med Genet , vol.7 , pp. 47-74
    • Hall, J.G.1    Pallister, P.D.2    Clarren, S.K.3    Beckwith, J.B.4    Wiglesworth, F.W.5    Fraser, F.C.6    Cho, S.7    Benke, P.J.8    Reed, S.D.9
  • 25
  • 26
    • 0037271083 scopus 로고    scopus 로고
    • Cord-like mosaic patches in the adrenal cortex are fractal: Implications for growth and development
    • Iannaccone P, Morley S, Skimina T, Mullins J, Landini G. 2003. Cord-like mosaic patches in the adrenal cortex are fractal: Implications for growth and development. FASEB J 17:41-43.
    • (2003) FASEB J , vol.17 , pp. 41-43
    • Iannaccone, P.1    Morley, S.2    Skimina, T.3    Mullins, J.4    Landini, G.5
  • 27
    • 0028276035 scopus 로고
    • Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
    • Baltimore, MD
    • Ikeda Y, Shen WH, Ingraham HA, Parker KL. 1994. Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol (Baltimore, MD) 8:654-662.
    • (1994) Mol Endocrinol , vol.8 , pp. 654-662
    • Ikeda, Y.1    Shen, W.H.2    Ingraham, H.A.3    Parker, K.L.4
  • 28
    • 0028959656 scopus 로고
    • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
    • Baltimore, MD
    • Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL. 1995. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol (Baltimore, MD) 9:478-486.
    • (1995) Mol Endocrinol , vol.9 , pp. 478-486
    • Ikeda, Y.1    Luo, X.2    Abbud, R.3    Nilson, J.H.4    Parker, K.L.5
  • 29
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP. 2001. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15: 3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 30
    • 10344248701 scopus 로고    scopus 로고
    • Of mice and men: The tale of steroidogenic factor-1
    • Jameson JL. 2004. Of mice and men: The tale of steroidogenic factor-1. J Clin Endocrinol Metab 89:5927-5929.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5927-5929
    • Jameson, J.L.1
  • 31
    • 0002246258 scopus 로고
    • Variation in the mouse adrenal cortex with special reference to the zona reticularis and to brown degeneration, together with a discussion of the 'cell migration' theory
    • Jones IC. 1948. Variation in the mouse adrenal cortex with special reference to the zona reticularis and to brown degeneration, together with a discussion of the 'cell migration' theory. Q J Microsc Sci s3-89:53-73.
    • (1948) Q J Microsc Sci , vol.S3-89 , pp. 53-73
    • Jones, I.C.1
  • 32
    • 0031019090 scopus 로고    scopus 로고
    • GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome
    • DOI 10.1038/ng0397-266
    • Kang S, Graham JM, Jr., Olney AH, Biesecker LG. 1997. GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nat Genet 15:266-268. (Pubitemid 27098719)
    • (1997) Nature Genetics , vol.15 , Issue.3 , pp. 266-268
    • Kang, S.1    Graham Jr., J.M.2    Olney, A.H.3    Biesecker, L.G.4
  • 34
    • 0036637499 scopus 로고    scopus 로고
    • Recent insights into organogenesis of the adrenal cortex
    • Keegan CE, Hammer GD. 2002. Recent insights into organogenesis of the adrenal cortex. Trends Endocrinol Metab 13: 200-208.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 200-208
    • Keegan, C.E.1    Hammer, G.D.2
  • 35
    • 33847211077 scopus 로고    scopus 로고
    • Adrenocortical cells with stem/progenitor cell properties: Recent advances
    • Kim AC, Hammer GD. 2007. Adrenocortical cells with stem/progenitor cell properties: Recent advances. Mol Cell Endocrinol 265-266:10-16.
    • (2007) Mol Cell Endocrinol , vol.265-266 , pp. 10-16
    • Kim, A.C.1    Hammer, G.D.2
  • 37
    • 75849118873 scopus 로고    scopus 로고
    • Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages
    • King P, Paul A, Laufer E. 2009. Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci USA 106:21185-21190.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21185-21190
    • King, P.1    Paul, A.2    Laufer, E.3
  • 38
    • 0028303959 scopus 로고
    • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
    • DOI 10.1016/0092-8674(94)90211-9
    • Luo X, Ikeda Y, Parker KL. 1994. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490. (Pubitemid 24153989)
    • (1994) Cell , vol.77 , Issue.4 , pp. 481-490
    • Luo, X.1    Ikeda, Y.2    Parker, K.L.3
  • 40
    • 0030456473 scopus 로고    scopus 로고
    • Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function
    • Morohashi KI, Omura T. 1996. Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function. FASEB J 10:1569-1577.
    • (1996) FASEB J , vol.10 , pp. 1569-1577
    • Morohashi, K.I.1    Omura, T.2
  • 41
    • 0032989104 scopus 로고    scopus 로고
    • Cryptorchidism in mice mutant for Insl3
    • Nef S, Parada LF. 1999. Cryptorchidism in mice mutant for Insl3. Nat Genet 22:295-299.
    • (1999) Nat Genet , vol.22 , pp. 295-299
    • Nef, S.1    Parada, L.F.2
  • 42
    • 21044446418 scopus 로고    scopus 로고
    • Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
    • Cambridge, England
    • Park SY, Meeks JJ, Raverot G, Pfaff LE, Weiss J, Hammer GD, Jameson JL. 2005. Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. Development (Cambridge, England) 132: 2415-2423.
    • (2005) Development , vol.132 , pp. 2415-2423
    • Park, S.Y.1    Meeks, J.J.2    Raverot, G.3    Pfaff, L.E.4    Weiss, J.5    Hammer, G.D.6    Jameson, J.L.7
  • 43
    • 34547132553 scopus 로고    scopus 로고
    • Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development
    • Park SY, Tong M, Jameson JL. 2007. Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development. Endocrinology 148:3704-3710.
    • (2007) Endocrinology , vol.148 , pp. 3704-3710
    • Park, S.Y.1    Tong, M.2    Jameson, J.L.3
  • 44
    • 56749136435 scopus 로고    scopus 로고
    • Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells
    • Pelusi C, Ikeda Y, Zubair M, Parker KL. 2008. Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells. Biol Reprod 79:1074-1083.
    • (2008) Biol Reprod , vol.79 , pp. 1074-1083
    • Pelusi, C.1    Ikeda, Y.2    Zubair, M.3    Parker, K.L.4
  • 46
    • 0034758841 scopus 로고    scopus 로고
    • A developmental study of the desert hedgehog-null mouse testis
    • Pierucci-Alves F, Clark AM, Russell LD. 2001. A developmental study of the Desert hedgehog-null mouse testis. Biol Reprod 65:1392-1402. (Pubitemid 33031496)
    • (2001) Biology of Reproduction , vol.65 , Issue.5 , pp. 1392-1402
    • Pierucci-Alves, F.1    Clark, A.M.2    Russell, L.D.3
  • 47
    • 66649099070 scopus 로고    scopus 로고
    • Dominant activation of the hedgehog signaling pathway in the ovary alters theca development and prevents ovulation
    • Baltimore, MD
    • Ren Y, Cowan RG, Harman RM, Quirk SM. 2009. Dominant activation of the hedgehog signaling pathway in the ovary alters theca development and prevents ovulation. Mol Endocrinol (Baltimore, MD) 23:711-723.
    • (2009) Mol Endocrinol , vol.23 , pp. 711-723
    • Ren, Y.1    Cowan, R.G.2    Harman, R.M.3    Quirk, S.M.4
  • 48
    • 0025934625 scopus 로고
    • A shared promoter element regulates the expression of three steroidogenic enzymes
    • Baltimore, MD
    • Rice DA, Mouw AR, Bogerd AM, Parker KL. 1991. A shared promoter element regulates the expression of three steroidogenic enzymes. Mol Endocrinol (Baltimore, MD) 5:1552-1561.
    • (1991) Mol Endocrinol , vol.5 , pp. 1552-1561
    • Rice, D.A.1    Mouw, A.R.2    Bogerd, A.M.3    Parker, K.L.4
  • 49
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP. 2007. Patched1 regulates hedgehog signaling at the primary cilium. Science 317:372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 51
    • 0028875430 scopus 로고
    • Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
    • Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J. 1995. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci USA 92:10939-10943.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10939-10943
    • Sadovsky, Y.1    Crawford, P.A.2    Woodson, K.G.3    Polish, J.A.4    Clements, M.A.5    Tourtellotte, L.M.6    Simburger, K.7    Milbrandt, J.8
  • 52
    • 85027472042 scopus 로고
    • A study of the life history of corticoadrenal gland cells of the rat by means of trypan blue injections
    • Salmon TN, Zwemer RL. 1941. A study of the life history of corticoadrenal gland cells of the rat by means of trypan blue injections. Anat Rec 80:421-429.
    • (1941) Anat Rec , vol.80 , pp. 421-429
    • Salmon, T.N.1    Zwemer, R.L.2
  • 53
    • 58149333236 scopus 로고    scopus 로고
    • Sex determination and SRY: Down to a wink and a nudge?
    • Sekido R, Lovell-Badge R. 2009. Sex determination and SRY: Down to a wink and a nudge? Trends Genet 25:19-29.
    • (2009) Trends Genet , vol.25 , pp. 19-29
    • Sekido, R.1    Lovell-Badge, R.2
  • 54
    • 0028308118 scopus 로고
    • Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: A link to the sex determination cascade
    • Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA. 1994. Nuclear receptor steroidogenic factor 1 regulates the Mullerian inhibiting substance gene: A link to the sex determination cascade. Cell 77:651-661. (Pubitemid 124000756)
    • (1994) Cell , vol.77 , Issue.5 , pp. 651-661
    • Shen, W.-H.1    Moore, C.C.D.2    Ikeda, Y.3    Parker, K.L.4    Ingraham, H.A.5
  • 55
    • 33644849523 scopus 로고    scopus 로고
    • Regulation of Gli1 localization by the cAMP/protein kinase a signaling axis through a site near the nuclear localization signal
    • Sheng T, Chi S, Zhang X, Xie J. 2006. Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J Biol Chem 281:9-12.
    • (2006) J Biol Chem , vol.281 , pp. 9-12
    • Sheng, T.1    Chi, S.2    Zhang, X.3    Xie, J.4
  • 57
    • 0000194243 scopus 로고
    • Adrenal regeneration and adrenal-regeneration hypertension
    • Skelton FR. 1959. Adrenal regeneration and adrenal-regeneration hypertension. Physiol Rev 39:162-182.
    • (1959) Physiol Rev , vol.39 , pp. 162-182
    • Skelton, F.R.1
  • 58
    • 70149116340 scopus 로고    scopus 로고
    • The hedgehog-patched signaling pathway and function in the mammalian ovary: A novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells
    • Spicer LJ, Sudo S, Aad PY, Wang LS, Chun SY, Ben-Shlomo I, Klein C, Hsueh AJ. 2009. The hedgehog-patched signaling pathway and function in the mammalian ovary: A novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction 138:329-339.
    • (2009) Reproduction , vol.138 , pp. 329-339
    • Spicer, L.J.1    Sudo, S.2    Aad, P.Y.3    Wang, L.S.4    Chun, S.Y.5    Ben-Shlomo, I.6    Klein, C.7    Hsueh, A.J.8
  • 59
    • 59949092788 scopus 로고    scopus 로고
    • Identification of hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system
    • Szczepny A, Hogarth CA, Young J, Loveland KL. 2009. Identification of hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system. Biol Reprod 80: 258-263.
    • (2009) Biol Reprod , vol.80 , pp. 258-263
    • Szczepny, A.1    Hogarth, C.A.2    Young, J.3    Loveland, K.L.4
  • 60
    • 33646869503 scopus 로고    scopus 로고
    • Multisite protein kinase a and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
    • Tempe D, Casas M, Karaz S, Blanchet-Tournier MF, Concordet JP. 2006. Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol 26:4316-4326.
    • (2006) Mol Cell Biol , vol.26 , pp. 4316-4326
    • Tempe, D.1    Casas, M.2    Karaz, S.3    Blanchet-Tournier, M.F.4    Concordet, J.P.5
  • 61
    • 64549156508 scopus 로고    scopus 로고
    • Nuclear receptors, testosterone, and posttranslational modifications in human INSL3 promoter activity in testicular Leydig cells
    • Tremblay JJ, Robert NM, Lague E. 2009. Nuclear receptors, testosterone, and posttranslational modifications in human INSL3 promoter activity in testicular Leydig cells. Ann N Y Acad Sci 1160:205-212.
    • (2009) Ann N Y Acad Sci , vol.1160 , pp. 205-212
    • Tremblay, J.J.1    Robert, N.M.2    Lague, E.3
  • 62
    • 0033754159 scopus 로고    scopus 로고
    • A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy
    • Umehara F, Tate G, Itoh K, Yamaguchi N, Douchi T, Mitsuya T, Osame M. 2000. A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. Am J Hum Genet 67:1302-1305.
    • (2000) Am J Hum Genet , vol.67 , pp. 1302-1305
    • Umehara, F.1    Tate, G.2    Itoh, K.3    Yamaguchi, N.4    Douchi, T.5    Mitsuya, T.6    Osame, M.7
  • 63
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M, Taipale J. 2008. Hedgehog: Functions and mechanisms. Genes Dev 22:2454-2472.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 64
    • 30444437000 scopus 로고    scopus 로고
    • Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
    • Wang B, Li Y. 2006. Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci USA 103:33-38.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 33-38
    • Wang, B.1    Li, Y.2
  • 65
    • 23044514938 scopus 로고    scopus 로고
    • Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells
    • Wijgerde M, Ooms M, Hoogerbrugge JW, Grootegoed JA. 2005. Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells. Endocrinology 146:3558-3566.
    • (2005) Endocrinology , vol.146 , pp. 3558-3566
    • Wijgerde, M.1    Ooms, M.2    Hoogerbrugge, J.W.3    Grootegoed, J.A.4
  • 66
    • 0036067874 scopus 로고    scopus 로고
    • Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis
    • Yao HH, Capel B. 2002. Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. Dev Biol 246:356-365.
    • (2002) Dev Biol , vol.246 , pp. 356-365
    • Yao, H.H.1    Capel, B.2
  • 67
    • 0036606827 scopus 로고    scopus 로고
    • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
    • Yao HH, Whoriskey W,Capel B. 2002. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev 16:1433-1440.
    • (2002) Genes Dev , vol.16 , pp. 1433-1440
    • Yao, H.H.1    Whoriskey, W.2    Capel, B.3
  • 68
    • 0023029273 scopus 로고
    • The streaming adrenal cortex: Direct evidence of centripetal migration of adrenocytes by estimation of cell turnover rate
    • Zajicek G, Ariel I, Arber N. 1986. The streaming adrenal cortex: Direct evidence of centripetal migration of adrenocytes by estimation of cell turnover rate. J Endocrinol 111:477-482. (Pubitemid 17207239)
    • (1986) Journal of Endocrinology , vol.111 , Issue.3 , pp. 477-482
    • Zajicek, G.1    Ariel, I.2    Arber, N.3
  • 69
    • 0032230347 scopus 로고    scopus 로고
    • Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1
    • Zimmermann S, Schwarzler A, Buth S, Engel W, Adham IM. 1998. Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1. Mol Endocrinol (Baltimore, MD) 12: 706-713. (Pubitemid 30659072)
    • (1998) Molecular Endocrinology , vol.12 , Issue.5 , pp. 706-713
    • Zimmermann, S.1    Schwarzler, A.2    Buth, S.3    Engel, W.4    Adham, I.M.5
  • 70
    • 57349088231 scopus 로고    scopus 로고
    • Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing
    • Zubair M, Parker KL, Morohashi K. 2008. Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing. Mol Cell Biol 28:7030-7040.
    • (2008) Mol Cell Biol , vol.28 , pp. 7030-7040
    • Zubair, M.1    Parker, K.L.2    Morohashi, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.