Identification of Hedgehog Signaling Outcomes in Mouse Testis Development Using a Hanging Drop-Culture System1

Biology of Reproduction

Volumn 80, Issue 2, 2009, Pages 258-263

  Szczepny, Anette ^a,b   Hogarth, Cathryn A ^a,c   Young, Julia ^a,c   Loveland, Kate L ^a,b,c  

^a MONASH UNIVERSITY   (Australia)

^b Australian Government Australian Research Council   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Gli1; Hedgehog; Organ culture; Spermatogenesis; Testis

Indexed keywords

CYCLIN B1; CYCLIN D2; CYCLOPAMINE; MUELLERIAN INHIBITING FACTOR; OSTEOPONTIN; SOMATOMEDIN BINDING PROTEIN 6; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GERM CELL; MALE; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERMATOGONIUM; TESTIS DEVELOPMENT;

ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; MALE; MICE; MICE, INBRED BALB C; PREGNANCY; SEMINIFEROUS TUBULES; SIGNAL TRANSDUCTION; TESTIS; VERATRUM ALKALOIDS;

ERINACEIDAE; MURINAE; RODENTIA;

EID: 59949092788     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.108.067926     Document Type: Article

References (26)

1. Szczepny A, Hime GR, Loveland KL. Expression of hedgehog signaling components in adult mouse testis. Dev Dyn 2006; 235:3063-3070.
2. Hooper JE, Scott MP. Communicating with hedgehogs. Nat Rev Mol Cell Biol 2005; 6:306-317.
3. Bitgood MJ, McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 1995; 172:126-138.
4. Bitgood MJ, Shen L, McMahon AP. Sertoli cell signaling by desert hedgehog regulates the male germline. Curr Biol 1996; 6:298-304.
5. Pierucci-Alves F, Clark AM, Russell LD. A developmental study of the desert hedgehog-null mouse testis. Biol Reprod 2001; 65:1392-1402.
6. Canto P, Soderlund D, Reyes E, Mendez JP. Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis. J Clin Endocrinol Metab 2004; 89:4480-4483.
7. Yao HH, Capel B. Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. Dev Biol 2002; 246:356-365.
8. Martineau J, Nordqvist K, Tilmann C, Lovell-Badge R, Capel B. Male- specific cell migration into the developing gonad. Curr Biol 1997; 7:958-968.
9. Meehan T, Schlatt S, O'Bryan MK, de Kretser DM, Loveland KL. Regulation of germ cell and Sertoli cell development by activin, follistatin, and FSH. Dev Biol 2000; 220:225-237.
10. Chuma S, Nakatsuji N. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev Biol 2001; 229:468-479.
11. Yao HH, Whoriskey W, Capel B. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev 2002; 16:1433-1440.
12. Loveland KL, Herszfeld D, Chu B, Rames E, Christy E, Briggs LJ, Shakri R, de Kretser DM, Jans DA. Novel low-molecular-weight microtubule- associated protein-2 isoforms contain a functional nuclear localization sequence. J Biol Chem 1999; 274:19261-19268.
13. Nagase M, Nagase T, Koshima I, Fujita T. Critical time window of hedgehog-dependent angiogenesis in murine yolk sac. Microvasc Res 2006; 71:85-90.
14. Russell MC, Cowan RG, Harman RM, Walker AL, Quirk SM. The hedgehog signaling pathway in the mouse ovary. Biol Reprod 2007; 77: 226-236.
15. Lamm ML, Catbagan WS, Laciak RJ, Barnett DH, Hebner CM, Gaffield W, Walterhouse D, Iannaccone P, Bushman W. Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol 2002; 249:349-366.
16. Dang SM, Kyba M, Perlingeiro R, Daley GQ, Zandstra PW. Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng 2002; 78: 442-453.
17. Kaufman MH. The Atlas of Mouse Development. London: Academic Press; 1995.
18. Lipinski RJ, Cook CH, Barnett DH, Gipp JJ, Peterson RE, Bushman W. Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn 2005; 233:829-836.
19. Ingram WJ, Wicking CA, Grimmond SM, Forrest AR, Wainwright BJ. Novel genes regulated by sonic hedgehog in pluripotent mesenchymal cells. Oncogene 2002; 21:8196-8205.
20. Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, Jacob H, Walterhouse D, Iannaccone P. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002; 277:5548-5555.
21. Aza-Blanc P, Lin HY, Ruiz i Altaba A, Kornberg TB. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 2000; 127:4293-4301.
22. Beumer TL, Roepers-Gajadien HL, Gademan IS, Kal HB, de Rooij DG. Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse. Biol Reprod 2000; 63:1893-1898.
23. Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 1996; 384:470-474.
24. Yoshinaga K, Nishikawa S, Ogawa M, Hayashi S, Kunisada T, Fujimoto T, Nishikawa S. Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development 1991; 113:689-699.
25. Hoei-Hansen CE, Nielsen JE, Almstrup K, Hansen MA, Skakkebaek NE, Rajpert-DeMeyts E, Leffers H. Identification of genes differentially expressed in testes containing carcinoma in situ. Mol Hum Reprod 2004; 10:423-431.
26. Rajpert-De Meyts E, Skakkebaek NE. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumors. Int J Androl 1994; 17:85-92.