Lipid emulsion therapy for local anaesthetic toxicity: (LipidRescue™);Lipidlösungen zur Therapie der Lokalanästhetikaintoxikation: (LipidRescueTM)

Anaesthesist

Volumn 59, Issue 6, 2010, Pages 575-586

  Ott, K ^a  

^a KLINIKUM AUGSBURG   (Germany)

Author keywords

Cardiotoxicity; Intoxication; Lipid emulsion; Local anaesthetics; Resuscitation

Indexed keywords

ADRENALIN; AMFEBUTAMONE; ANTICONVULSIVE AGENT; BUPIVACAINE; HYPERTENSIVE FACTOR; INTRALIPID; LAMOTRIGINE; LEVOBUPIVACAINE; LIDOCAINE; LIPID EMULSION; LIPIDRESCUE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; PRILOCAINE; PROCAINE; PROPRANOLOL; PROSTACYCLIN; ROPIVACAINE; TETRACAINE; THROMBOXANE A2; UNCLASSIFIED DRUG; VASOCONSTRICTOR AGENT;

ACIDOSIS; ACTION POTENTIAL; AIRWAY; CENTRAL NERVOUS SYSTEM DISEASE; COMORBIDITY; CONFUSION; DRUG INTOXICATION; DRUG METABOLISM; ELECTROCARDIOGRAM; ENANTIOMER; EPIDURAL CATHETER; EXTRACORPOREAL CIRCULATION; EXTRASYSTOLE; HEART ARREST; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOXIA; LIPOPHILICITY; LOCAL ANESTHESIA; MEDICAL HISTORY; NERVE BLOCK; PLASMA PROTEIN BINDING; RESPIRATORY ACIDOSIS; RESUSCITATION; REVIEW; ST SEGMENT; TONIC CLONIC SEIZURE; VERTIGO; CHEMICALLY INDUCED; INTRAOPERATIVE COMPLICATIONS; PSYCHOLOGY; TOXICITY;

ANESTHETICS, LOCAL; CARDIOPULMONARY RESUSCITATION; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; HUMANS; INTRAOPERATIVE COMPLICATIONS; VASOCONSTRICTOR AGENTS;

EID: 77954423980     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00101-010-1724-8     Document Type: Review

References (58)

1. Apfelbaum JL, Shaw LM, Gross JB et al (1985) Modification of lidocaine protein binding with CO2. Can Anaest Soc J 32:468-471
2. Association of Anaesthetists of Great Britain and Ireland (2007) Guidelines for the management of severe local anaesthetic toxicity. *http://www.aagbi.org/publications/guidelines/docs/latoxicity07.pdf
3. Auroy Y, Narchi P, Messiah A et al (1997) Serious complications related to regional anesthesia: results of a prospective survey in France. Anes-thesiology 87:479-486
4. Brown DL, Ransom DM, Hall JA et al (1995) Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompany-ing cardiovascular changes. Anesth Analg 81:321-328
5. Brull R, Colin JL, McCartney V et al (2007) Neurological complications after regional anesthesia: contempo-rary estimates of risk. Anesth Analg 104:965-974 (Pubitemid 46548330)
6. Brull SJ (2008) Lipid emulsion for the treatment of local anesthetic toxicity: patient safety implications. Anesth Analg 106:1337-1339
7. Burney RG, DiFazio CA, Foster JA (1978) Effects of pH on protein bin-ding of lidocaine. Anesth Analg 57:478-480
8. Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the ac-tion potential with slow recovery from block during diastole. Anesthesiology 62:396-405
9. Corcoran W, Butterworth J, Weller RS et al (2006) Local anesthetic-induced cardiac toxicity: a survey of contem-porary practice strategies among academic anesthesiology depart-ments. Anesth Analg 103:1322-1326
10. Cox B, Durieux ME, Marcus MAE (2003) Toxicity of local anaesthetics. Best Pract Res Clin Anaesthesiol 17:111-136
11. Denson DD, Behbehani MM, Gregg RV (1992) Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovas-cular system in the anesthetized rat. Reg Anesth Pain Med 17:311-316
12. Espinet AJ, Emmerton MT (2009) The successful use of intralipid for treatment of local anesthetic-induced central nervous system toxicity: some considerations for administra-tion of intralipid in an emergency. Clin J Pain 25:808-809
13. Finn SDH, Uncles DR, Willers J, Sable N (2009) Early treatment of a quetiapine and sertraline overdose with Intralipid. Anaesthesia 64:191-194
14. Foxall GR, McCahon JL, Hardman JG, Bedforth NM (2007) Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 62:516-518
15. Graf BM (2001) The cardiotoxicity of local anesthetics: the place of ropivacaine. Curr Top Med Chem 1:207-214
16. Groban L, Deal DD, Vernon JC et al (2001) Cardiac resuscitation after in-cremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 92:37-43
17. Harvey M, Grant C (2009) Bupivacaine-induced cardiac arrest: fat is good is epinephrine really bad? Anesthesiology 111:467-469
18. Harvey MG, Grant RC (2008) Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. J Med Toxicol 4:71-76
19. Hiller DB, DiGregorio G, Ripper R et al (2009) Epinephrine impairs lipid Resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology 111:498-505
20. Jasnosz KM, Pickeral JJ, Graner S (1995) Fat deposits in the placenta following maternal total parenteral nutrition with intravenous lipid emulsion. Arch Pathol Lab Med 119:555-557
21. Knudsen K, Beckman Suurkula M, Blomberg S et al (1997) Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 78:507-514
22. Koscielniak-Nielsen ZJ (2008) Ultra-sound-guided peripheral nerve blocks: what are the benefits? Acta Anaesthesiol Scand 52:727-737
23. Leone S, Di Cianni S, Casati A, Fanelli G (2008) Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed 79:92-105
24. Litz RJ, Popp M, Stehr SN, Koch T (2006) Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 61:800-801
25. Litz RJ, Roessel R, Heller AR, Stehr SN Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg 106:1575-1577
26. Ludot H, Tharin JY, Belouadah M et al (2008) Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 106:1572-1574
27. Marwick PC, Levin AI, Coetzee AR (2006) Recurrence of cardiotoxicity after lipid rescue from bupivacaineinduced cardiac arrest. Anesth Analg 108:1344-1346
28. Mayr VD, Mitterschiffthaler L, Neurauter A et al (2008) A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial car-diac arrest after intravenous injection of bupivacaine. Anesth Analg 106:1566-1571
29. Mazoit JX, Le Guen R, Beloeil H, Benhamou D (2009) Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 110:380-386
30. Mulroy MF (2002) Systemic toxicity and cardiotoxicity from local anes-thetics: incidence and preventive measures. Reg Anesth Pain Med 27:556-561
31. Picard J, Harrop-Griffiths W (2009) Lipid emulsion to treat drug overdose: past, present and future. Anaesthesia 64:119-121
32. Picard J, Ward SC, Zumpe R et al (2009) Guidelines and the adoption of,lipid rescue' therapy for local anaesthetic toxicity. Anaesthesia 64:122-125
33. Picard J, Meek T (2006) Lipid emulsi-on to treat overdose of local anaesthetic: the gift of the glob. Anaesthe-sia 61:107-109
34. Rosenblatt MA, Abel M, Fischer GW et al (2006) Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacainerelated cardiac arrest. Anesthesiology 105:217-218
35. Ruetsch YA, Boni T, Borgeat A (2001) From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem 1:175-182
36. Schulz-Stubner S (2008) Lokalan asthetika. In: Rossaint R, Werner C, ZwiBler B (Hrsg) Die Anasthesiologie, 2. Aufl. Springer, Berlin, Heidelberg, New York Tokio, S 353
37. Sirriani AJ, Osterhoudt KC, Calello DP et al (2008) Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 51:412-415
38. Smirniotis V, Kotsis TE, Antoniou S et al (1999) Incidence of vein thrombo-sis in peripheral intravenous nutriti-on: effect of fat emulsions. Clin Nutr 18:79-81
39. Smith HM, Jacob AK, Segura LG et al (2008) Simulation education in anes-thesia training: a case report of suc-cessful resuscitation of bupivacaineinduced cardiac arrest linked to recent simulation training. Anesth Analg 106:1581-1584
40. Spence AG (2007) Lipid reversal of central nervous system symptoms of bupiva caine toxicity. Anesthesiology 107:516-517
41. Stehr SN, Ziegeler JC, Pexa A et al (2007) The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 104:186-192 (Pubitemid 46360445)
42. Suchner U, Katz DP, Furst P et al (2001) Effects of intravenous fat emulsions on lung function in patients with acute respiratory distress syndrome or sepsis. Crit Care Med 29(8):1569-1574
43. Suchner U, Katz DP, Furst P et al (2002) Impact of sepsis, lung injury, and the role of lipid infusion on cir-culating prostacyclin and thromboxane A(2). Intensive Care Med 28(2):122-129
44. Takifuji K, Tanimura H (1998) Adverse effects of intravenous fat emulsion administration. Nippon Geka Gakkai Zasshi 99:171-175
45. Tucker GT (1986) Pharmacokinetics of local anaesthetics. Br J Anaesth 58:717-731
46. Volk T, Engelhardt L, Spies C et al (2009) Infektionsinzidenz von Katheterve rfahren zur Regionalanasthesie. Erste Ergebnisse aus dem Netzwerk von DGAI und BDA. Anaesthesist 58:1107-1112
47. Volk T, Graf BM, Gogarten W et al (2009) Empfehlungen zur Lipidbehandlung bei der Intoxikation mit Lokalanasthetika. Anasthesiol Intensivmed Notfallmed Schmerzther 50:698-702
48. Warren JA, Thoma RB, Georgescu A, Shah SJ (2008) Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardio-vascular collapse after supraclavicu-lar brachial plexus block. Anesth An-alg 106:1578-1580
49. Weidmann B, Lepique C, Heider A et al (1997) Hypersensitivity reactions to parenteral lipid solutions. Support Care Cancer 5:504-505
50. Weinberg GL, Palmer JW, VadeBoncouer TR et al (2000) Bupivacaine in-hibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 92:523-528
51. Weinberg GL, VadeBoncouer T, Ramaraju GA et al (1998) Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 88:1071-1075
52. Weinberg GL (2006) Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology 105:7-8
53. Weinberg GL, Paisanthasan C, Feinstein D, Hoffman W (2004) The effect of bupivacaine on myocardi-al tissue hypoxia and acidosis during ventricular fibrillation. Anesth Analg 98:790-795
54. Weinberg GL, Ripper R, Feinstein DL, Hoffman W (2003) Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 28:198-202
55. Weinberg GL, DiGregorio G, Ripper R et al (2008) Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 108:907-913
56. Weinberg GL, Ripper R, Murphy P et al (2006) Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 31:296-303
57. Zimmer C, Piepenbrink K, Riest G, Peters J (2007) Kardiound neurotoxische Nebenwirkungen nach akzidenteller intravasaler Bupivacainapplikation. Therapie mit Lidocain, Propofol und Lipidemulsion. Anaesthesist 56:449-453
58. Zink W, Graf BM (2003) Toxikologie der Lokalanasthetika. Pathomechanismen Klinik Therapie. Anaesthesist 52:1102-1123