Lipid emulsion to treat drug overdose: Past, present and future

Anaesthesia

Volumn 64, Issue 2, 2009, Pages 119-121

  Picard, J ^a   Harrop Griffiths, W ^a  

^a NATIONAL HEALTH SERVICE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; BUPIVACAINE; LAMOTRIGINE; LEVOBUPIVACAINE; LIDOCAINE; LIPID EMULSION; MEPIVACAINE; PRILOCAINE; ROPIVACAINE; LOCAL ANESTHETIC AGENT;

CARDIOTOXICITY; DRUG OVERDOSE; EDITORIAL; HEART ARREST; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; MEDICAL SOCIETY; RESUSCITATION; UNITED KINGDOM; ANESTHESIOLOGY; CHEMICALLY INDUCED DISORDER; INTOXICATION; NOTE;

ANESTHESIOLOGY; ANESTHETICS, LOCAL; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; HUMANS; OVERDOSE;

EID: 59449093068     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/j.1365-2044.2008.05830.x     Document Type: Editorial

References (21)

1. Picard J, Meek T. Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia 2006; 61: 107-9.
2. Litz RJ, Popp M, Stehr SN, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006; 61: 800-1.
3. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105: 217-18.
4. Warren JA, Thoma RB, Georgescu A, Shah SJ. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesthesia and Analgesia 2008; 106: 1578-80.
5. Zimmer C, Piepenbrink K, Riest G, Peters J. [Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion]. Anaesthesist 2007; 56: 449-53.
6. Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM. Levo-bupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007; 62: 516-18.
7. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesthesia and Analgesia 2008; 106: 1572-4.
8. Litz RJ, Roessel T, Heller AR, Stehr SN. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesthesia and Analgesia 2008; 106: 1575-7.
9. Spence AG. Lipid reversal of central nervous system symptoms of bupiva-caine toxicity. Anesthesiology 2007; 107: 516-17.
10. Association of Anaesthetists of Great Britain and Ireland. http://www.aagbi.org/publications/guidelines/docs/latoxicity07.pdf (accessed 13 October 2008).
11. Williamson RM, Haines J. Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey. Anaesthesia 2008; 63: 385-8.
12. Picard J, Ward SC, Zumpe R, Meek T, Barlow J, Harrop-Griffiths W. Guidelines and the adoption of 'lipid rescue' therapy for local anaesthetic toxicity. Anaesthesia 2009; 64: 122-5.
13. Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108: 907-13.
14. Weinberg GL, Palmer JW, Vade-Boncouer TR, Zuechner MB, Edelman G, Hoppel CL. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 2000; 92: 523-8.
15. Edelman LB, Ripper R, Kelly K, Di Gregorio G, Weinberg GL. Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart. Chemico-Biological Interactions 2008; 172: 48-53.
16. Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Academic Emergency Medicine 2006; 13: 134-9.
17. Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxic-ity. Annals of Emergency Medicine 2007; 49: 178-85, 85.e1-4.
18. Harvey MG, Cave GR. Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. Journal of Medical Toxicology 2008; 4: 71-6.
19. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotri-gine. Annals of Emergency Medicine 2008; 51: 412-15, 415.e1.
20. Finn SDH, Uncles DR, Willers J, Sable N. Early treatment of a quetia-pine and sertraline overdose with Intralipid®. Anaesthesia 2009; 64: 191-4.
21. Longmore JM, Wilkinson IB, Turm-ezei T, Cheung CK. Oxford Handbook of Clinical Medicine, 7th edn. Oxford: Oxford University Press, 2007.