Lipid infusion resuscitation for local anesthetic toxicity: Proof of clinical efficacy

Anesthesiology

Volumn 105, Issue 1, 2006, Pages 7-8

  Weinberg, Guy ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIPID EMULSION; MEPIVACAINE; LOCAL ANESTHETIC AGENT;

ADULT; ANESTHESIA COMPLICATION; ANIMAL MODEL; ASYSTOLE; CARDIOTOXICITY; CARNITINE DEFICIENCY; CASE REPORT; CORONARY ARTERY DISEASE; EDITORIAL; ELECTIVE SURGERY; HEART ARREST; HEART VENTRICLE TACHYCARDIA; HUMAN; JOINT SURGERY; MALE; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; SEIZURE; SHOULDER; TREATMENT OUTCOME; CHEMICALLY INDUCED DISORDER; METHODOLOGY; MIDDLE AGED; NOTE;

ANESTHETICS, LOCAL; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; HUMANS; MALE; MIDDLE AGED; RESUSCITATION;

EID: 33746864495     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200607000-00005     Document Type: Editorial

References (9)

1. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. ANESTHESIOLOGY 2006; 105:217-8
2. Weinberg GL, Laurito CE, Geldner P, Pygon BH, Burton BK: Malignant ventricular dysrhythmias in a patient with isovaleric acidemia receiving general and local anesthesia for suction lipectomy. J Clin Anesth 1997; 9:668-70
3. Weinberg GL, Palmer JW, VadeBoncouer TR, Zuechner MB, Edelman G, Hoppel CL: Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. ANESTHESIOLOGY 2000; 92:523-8
4. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ: Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. ANESTHESIOLOGY 1998; 88:1071-5
5. Weinberg G, Ripper R, Feinstein DL, Hoffman W: Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28:198-202
6. Corcoran W, Beck C, Gerancher J, Butterworth J, Groban L: Local anesthetic-induced cardiac toxicity: A survey of contemporary practice strategies among academic anesthesiology departments (abstract). Anesth Analg 2006; 102:S-316
7. Weinberg G, Paisanthasan C, Feinstein D, Hoffman W: The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. Anesth Analg 2004; 98:790-5
8. Weinberg G, Murphy P, Edelman L, Hoffman W, Strichartz G, Feinstein D: Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006; in press
9. Stehr S, Ziegeler J, Pexa A, Oertel R, Deussen A, Koch T, Hubler M: Lipid effects on myocardial function in L-bupivacaine induced toxicity in the isolated rat heart (abstract). Reg Anesth Pain Med 2005; 30:5