Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Ma, Haiqing ^a   Weng, Desheng ^a   Chen, Yibing ^a   Huang, Wei ^a   Pan, Ke ^a   Wang, Hui ^a   Sun, Jiancong ^a   Wang, Qijing ^a   Zhou, Zhiwei ^a   Wang, Huiyun ^a   Xia, Jianchuan ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METHYLTESTOSTERONE; HOMEODOMAIN PROTEIN; TES PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CANCER INHIBITION; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE IDENTIFICATION; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC CODE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PRIMARY TUMOR; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER; STOMACH CARCINOGENESIS; SURVIVAL TIME; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; CHROMOSOME 7; GENETICS; MIDDLE AGED; STOMACH TUMOR;

BLOTTING, WESTERN; CHROMOSOMES, HUMAN, PAIR 7; FEMALE; GENES, TUMOR SUPPRESSOR; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 77954422734     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-190     Document Type: Article

References (25)

1. Phan AT, Ajani JA. Gastric carcinoma. Curr Oncol Rep 2004, 6(3):192-198. 10.1007/s11912-004-0049-7, 15066230.
2. Nishizuka S, Tamura G, Terashima M, Satodate R. Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach. Br J Cancer 1997, 76(12):1567-1571. 2228190, 9413943.
3. Xia JC, Weng DS, Li JT, Qin HD, Mai SJ, Feng BJ, Fan Q, Feng QS, Huang LX, Yu XJ, Pan ZZ, Li YQ, Wang QJ, Zhan YQ, Chen SP, He J, Huang WL, Wu PH, Zeng YX. Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31. Cancer Genet Cytogenet 2006, 166(2):166-172. 10.1016/j.cancergencyto.2005.11.005, 16631475.
4. Wang HY, Luo M, Tereshchenko IV, Frikker DM, Cui X, Li JY, Hu G, Chu Y, Azaro MA, Lin Y, Shen L, Yang Q, Kambouris ME, Gao R, Shih W, Li H. A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome. Genome Res 2005, 15(2):276-283. 10.1101/gr.2885205, 546529, 15687291.
5. Zenklusen JC, Conti CJ, Green ED. Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. Nat Genet 2001, 27(4):392-398. 10.1038/86891, 11279520.
6. Engelman JA, Zhang XL, Galbiati F, Lisanti MP. Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31). FEBS Lett 1998, 429(3):330-336. 10.1016/S0014-5793(98)00619-X, 9662443.
7. Drusco A, Zanesi N, Roldo C, Trapasso F, Farber JL, Fong LY, Croce CM. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci USA 2005, 102(31):10947-10951. 10.1073/pnas.0504934102, 1182460, 16033868.
8. Gunduz E, Gunduz M, Beder L, Nagatsuka H, Fukushima K, Sutcu R, Delibas N, Yamanaka N, Shimizu K, Nagai N. Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2009, 135(3):254-260. 10.1001/archoto.2008.560, 19289703.
9. Sarti M, Sevignani C, Calin GA, Aqeilan R, Shimizu M, Pentimalli F, Picchio MC, Godwin A, Rosenberg A, Drusco A, Negrini M, Croce CM. Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. Clin Cancer Res 2005, 11(2 Pt 1):806-813.
10. Tatarelli C, Linnenbach A, Mimori K, Croce CM. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Genomics 2000, 68(1):1-12. 10.1006/geno.2000.6272, 10950921.
11. Tobias ES, Hurlstone AF, MacKenzie E, McFarlane R, Black DM. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene 2001, 20(22):2844-2853. 10.1038/sj.onc.1204433, 11420696.
12. Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980, 20(1):85-93. 10.1016/0092-8674(80)90237-8, 6156004.
13. Li JT, Fu L, Xia JC, Feng BJ, Mai SJ, Yu XJ, Huang LX, Feng QS, Pan ZZ, Zhan YQ. Minimal commonly deleted regions on chromosome 7q31 in primary gastric carcinoma and its clinical significance. Ai Zheng 2005, 24(11):1306-1311.
14. Weng DS, Li JT, Mai SJ, Pan ZZ, Feng BJ, Feng QS, Huang LX, Wang QJ, Li YQ, Yu XJ, Chen SP, He J, Xia JC. Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity. World J Gastroenterol 2006, 12(15):2437-2440.
15. Barresi V, Giuffre G, Vitarelli E, Todaro P, Tuccari G. Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses. Virchows Arch 2008, 453(6):571-578. 10.1007/s00428-008-0681-y, 18936967.
16. Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC. Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Cancer Lett 2008, 261(2):183-192. 10.1016/j.canlet.2007.11.019, 18160212.
17. Chene L, Giroud C, Desgrandchamps F, Boccon-Gibod L, Cussenot O, Berthon P, Latil A. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. Int J Cancer 2004, 111(5):798-804. 10.1002/ijc.20337, 15252854.
18. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000, 16(4):168-174. 10.1016/S0168-9525(99)01971-X, 10729832.
19. Singal R, Ginder GD. DNA methylation. Blood 1999, 93(12):4059-4070.
20. Huang Q, Sacks PG, Mo J, McCormick SA, Iacob CE, Guo L, Schaefer S, Schantz SP. A simple method for fixation and microdissection of frozen fresh tissue sections for molecular cytogenetic analysis of cancers. Biotech Histochem 2005, 80(3-4):147-156. 10.1080/10520290500382806, 16298900.
21. Zhang HK, Ma HQ, Wang QJ, Chen MS, Weng DS, Wang H, Zhou J, Li YQ, Sun JC, Chen YB, Liang XT, Zhao JJ, Pan K, Wang H, Xia JC. Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncol Rep 2010, 23(2):445-55.
22. Pastinen T, Kurg A, Metspalu A, Peltonen L, Syvanen AC. Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays. Genome Res 1997, 7(6):606-614.
23. Pastinen T, Raitio M, Lindroos K, Tainola P, Peltonen L, Syvanen AC. A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays. Genome Res 2000, 10(7):1031-1042. 10.1101/gr.10.7.1031, 310927, 10899152.
24. Shumaker JM, Metspalu A, Caskey CT. Mutation detection by solid phase primer extension. Hum Mutat 1996, 7(4):346-354. 10.1002/(SICI)1098-1004(1996)7:4<346::AID-HUMU9>3.0.CO;2-6, 8723685.
25. Hu G, Wang HY, Greenawalt DM, Azaro MA, Luo M, Tereshchenko IV, Cui X, Yang Q, Gao R, Shen L, Li H. AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays. Nucleic Acids Res 2006, 34(17):e116. 10.1093/nar/gkl601, 1635267, 16982644.