Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma

Archives of Otolaryngology - Head and Neck Surgery

Volumn 135, Issue 3, 2009, Pages 254-260

  Gunduz, Esra ^a,d   Gunduz, Mehmet ^a,c,d   Beder, Levent ^d   Nagatsuka, Hitoshi ^a   Fukushima, Kunihiro ^c   Sutcu, Recep ^e   Delibas, Namik ^e   Yamanaka, Noboru ^d   Shimizu, Kenji ^b   Nagai, Noriyuki ^a  

^a Departments of Oral Pathology and Medicine   (Japan)

^b Department of Molecular Genetics ^*  (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^e SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; MESSENGER RNA; NUCLEOTIDE;

ADULT; AGED; ANAMNESIS; ARTICLE; CANCER SURVIVAL; CARCINOGENESIS; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MEDICAL RESEARCH; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TESTIN GENE; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HOMEODOMAIN PROTEINS; HUMANS; JAPAN; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEINS;

EID: 63049131849     PISSN: 08864470     EISSN: 08864470     Source Type: Journal    
DOI: 10.1001/archoto.2008.560     Document Type: Article

References (23)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108.
2. Croce CM. Genetic approaches to the study of the molecular basis of human cancer. Cancer Res. 1991;51(18)(suppl):5015s-5018s.
3. Cowan JM, Beckett MA, Ahmed-Swan S, Weichselbaum RR. Cytogenetic evidence of the multistep origin of head and neck squamous cell carcinomas. J Natl Cancer Inst. 1992;84(10):793-797.
4. Edelson MI, Scherer SW, Tsui LC, et al. Identification of a 1300 kilobase deletion unit on chromosome 7q31.3 in invasive epithelial ovarian carcinomas. Oncogene. 1997;14(24):2979-2984.
5. Lin JC, Scherer SW, Tougas L, et al. Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET. Oncogene. 1996;13(9):2001-2008.
6. Shridhar V, Sun QC, Miller OJ, Kalemkerian GP, Petros J, Smith DI. Loss of het- erozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas. Oncogene. 1997;15(22):2727-2733.
7. Takahashi S, Shan AL, Ritland SR, et al. Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression. Cancer Res. 1995;55(18):4114-4119.
8. Wang XL, Uzawa K, Miyakawa A,et al. Localization of atumour-suppressor gene associated with human oral cancer on 7q31.1. Int J Cancer. 1998;75(5):671-674.
9. Zenklusen JC, Thompson JC, Klein-Szanto AJP, Conti CJ. Frequent loss of het- erozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res. 1995;55(6): 1347-1350.
10. Zhang JS, Nelson M, Mciver B, et al. Differential loss of heterozygosity at 7q31.2 in follicular and papillary thyroid tumors. Oncogene. 1998;17(6):789-793.
11. Zenklusen JC, Oshimura M, Barrett JC, Conti CJ. Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumorsuppres- sor gene on human chromosome 7. Oncogene. 1994;9(10):2817-2825.
12. Zenklusen JC, Hodges LC, Lacava M, Green ED, Conti CJ. Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site. Oncogene. 2000;19(13):1729-1733.
13. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol. 1993;13(10):6036-6043.
14. Gunduz M, Ouchida M, Fukushima K, et al. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene. 2002;21(28):4462-4470.
15. Tatarelli C, Linnenbach A, Mimori K, Croce CM. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Genomics. 2000;68(1): 1-12.
16. Sarti M, Sevignani C, Calin GA, et al. Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduc- tioninvivo. Clin Cancer Res. 2005;11(2 Pt 1):806-813.
17. Drusco A, Zanesi N, Roldo C, et al. Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci USA. 2005;102(31):10947-10951.
18. Chêne L, Giroud C, Desgrandchamps F, et al. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. Int J Cancer. 2004;111(5):798-804.
19. Mueller W, Nutt CL, Ehrich M, et al. Downregulation of RUNX3 and TES by hy- permethylation in glioblastoma. Oncogene. 2007;26(4):583-593.
20. Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 1971;68(4):820-823.
21. Bai F, Pei XH, Godfrey VL, Xiong Y. Haploinsufficiency of p18 (INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Mol Cell Biol. 2003;23(4):1269- 1277.
22. Tang B, Bottinger EP, Jakowlew SB, et al. Transforming growth factor-[31isa new form of tumor suppressor with true haploid insufficiency. Nat Med. 1998; 4(7):802-807.
23. Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet. 2007;16(R1):R50-R59. doi:10.1093/hmg/ddm018.