Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31

Nature Genetics

Volumn 27, Issue 4, 2001, Pages 392-398

  Zenklusen, Jean C ^a   Conti, Claudio J ^b   Green, Eric D ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL PROLIFERATION; CHROMOSOME 7Q; CHROMOSOME INACTIVATION; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; GENETIC CONSERVATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 7; DNA; GENES, TUMOR SUPPRESSOR; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035065492     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/86891     Document Type: Article

References (50)

1. The hallmarks of cancer
2. Detection of monosomy 7 and trisomy 8 in myeloid neoplasia: A comparison of banding and fluorescence in situ hybridization
3. Comparison of cytogenetic and restriction fragment length polymorphism analyses for the detection of loss of chromosome material in clonal hemopoietic disorders
4. High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination
5. Cytogenetic, molecular and functional evidence for novel tumor suppressor genes on the long arm of human chromosome 7
6. Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer
7. (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer
8. Loss of heterozygosity in human primary prostate carcinomas: A possible tumor suppressor gene at 7q31.1
9. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma
10. Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer
11. Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene
12. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: Evidence for a broad range tumor suppressor gene
13. Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach
14. Chromosome 7q allelic losses in pancreatic carcinoma
15. Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas
16. Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant myeloid disorders
17. Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7
18. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1
19. Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7
20. Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site
21. Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma
22. Construction of a high-resolution physical map of the approximate 1-Mb region of human chromosome 7q31.1-q31.2 harboring a putative tumor suppressor gene
23. A physical map of 30,000 human genes
24. A physical map of human chromosome 7: An integrated YAC contig map with average STS spacing of 79 kb
25. Finding the genes in genomic DNA
26. An improved system for exon recognition and gene modeling in human DNA sequences
27. PowerBLAST: A new network BLAST application for interactive or automated sequence analysis annotation
28. Cystic fibrosis: Channel, catalytic, and folding properties of the CFTR protein
29. Met-HGF/SF: Tumorigenesis, invasion, and metastasis
30. Compartment switching of WNT-2 expression in human breast tumors
31. Purification and characterization of smooth muscle cell caveolae
32. Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines
33. Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin
34. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
35. Ankyrin-8 is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins
36. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual
37. ProDom and ProDom-CG: Tools for protein domain analysis and whole genome comparisons
38. Prostate carcinoma: Tissue culture cell lines
39. Plymate, 5.R. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer
40. Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer
41. Allelotyping of acute myelogenous leukemia: Loss of heterozygosity at 7q31.1 (D75486) and q33-34 (D7S498, D7S505)
42. Genetic alteration mapping on chromosome 7 in primary breast cancer
43. Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET
44. Characterization of a multi-tissue tumour suppressor and senescence gene
45. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2
46. Dominant negative inhibition by fragments of a monomeric enzyme
47. Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma
48. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
49. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer
50. Preparation and analysis of DNA